Lee Argov EJ, Lui ML, Karr AG, Tehranifar P, Kehm RD. Breast Cancer Incidence Trends in Older US Women by Race, Ethnicity, Geography, and Stage. JAMA Netw Open. 2025;8:e2516947. https://doi.org/10.1001/jamanetworkopen.2025.16947.

Article  PubMed  PubMed Central  Google Scholar 

Cathcart-Rake EJ, Ruddy KJ, Bleyer A, Johnson RH. Breast Cancer in Adolescent and Young Adult Women Under the Age of 40 Years. JCO Oncol Pract United States. 2021;17:305–13. https://doi.org/10.1200/OP.20.00793.

Article  Google Scholar 

Ward ZJ, Bleich SN, Cradock AL, Barrett JL, Giles CM, Flax C, et al. Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity. New Engl J Med Mass Med Soc. 2019;381:2440–50. https://doi.org/10.1056/NEJMsa1909301.

Article  Google Scholar 

Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body Fatness and Cancer — Viewpoint of the IARC Working Group. New Engl J Med Mass Med Soc. 2016;375:794–8. https://doi.org/10.1056/NEJMsr1606602.

Article  Google Scholar 

Chew SM, Liu B, Shen S, Iyengar NM. The Role of Obesity and Inflammation in Breast Cancer Recurrence. Curr Breast Cancer Rep. 2024;16:237–50. https://doi.org/10.1007/s12609-024-00550-5.

Article  Google Scholar 

Drucker DJ. Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell Metabolism. Elsevier. 2018;27:740–56. https://doi.org/10.1016/j.cmet.2018.03.001.

Article  CAS  Google Scholar 

Picon-Ruiz M, Morata‐Tarifa C, Valle‐Goffin JJ, Friedman ER, Slingerland JM. Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA Cancer J Clin. 2017;67:378–97. https://doi.org/10.3322/caac.21405.

Article  PubMed  PubMed Central  Google Scholar 

Pan SY, Johnson KC, Ugnat A-M, Wen SW, Mao Y, Canadian Cancer Registries Epidemiology Research Group. Association of obesity and cancer risk in Canada. Am J Epidemiol. 2004;159:259–68. https://doi.org/10.1093/aje/kwh041.

Article  PubMed  Google Scholar 

Iyengar NM, Arthur R, Manson JE, Chlebowski RT, Kroenke CH, Peterson L, et al. Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index: A Secondary Analysis of a Randomized Clinical Trial and Observational Study. JAMA Oncol. 2019;5:155–63. https://doi.org/10.1001/jamaoncol.2018.5327.

Article  PubMed  PubMed Central  Google Scholar 

Park Y-MM, White AJ, Nichols HB, O’Brien KM, Weinberg CR, Sandler DP. The association between metabolic health, obesity phenotype and the risk of breast cancer. Int J Cancer. 2017;140:2657–66. https://doi.org/10.1002/ijc.30684.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen S, Brown KA, Green AK, Iyengar NM. Obesity and Cancer: A Translational Science Review. JAMA. 2026;335:1341. https://doi.org/10.1001/jama.2026.1114.

Article  CAS  PubMed  Google Scholar 

Vance V, Mourtzakis M, McCargar L, Hanning R. Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev. 2011;12:282–94. https://doi.org/10.1111/j.1467-789X.2010.00805.x.

Article  CAS  PubMed  Google Scholar 

Demark-Wahnefried W, Campbell K, Hayes SC. Weight management and its role in breast cancer rehabilitation. Cancer. 2012;118. https://doi.org/10.1002/cncr.27466.

van den Berg MMGA, Winkels RM, de Kruif JThCM HWM, Visser M, de Vries JHM, et al. Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer. 2017;17:259. https://doi.org/10.1186/s12885-017-3242-4.

Article  PubMed  PubMed Central  Google Scholar 

Dieli-Conwright CM, Wong L, Waliany S, Bernstein L, Salehian B, Mortimer JE. An observational study to examine changes in metabolic syndrome components in patients with breast cancer receiving neoadjuvant or adjuvant chemotherapy. Cancer. 2016;122:2646–53. https://doi.org/10.1002/cncr.30104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harvie MN, Campbell IT, Baildam A, Howell A. Energy balance in early breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Res Treat. 2004;83:201–10. https://doi.org/10.1023/B:BREA.0000014037.48744.fa.

Article  CAS  PubMed  Google Scholar 

Godinho-Mota JCM, Mota JF, Gonçalves LV, Soares LR, Schincaglia RM, Prado CM, et al. Chemotherapy negatively impacts body composition, physical function and metabolic profile in patients with breast cancer. Clin Nutr. 2021;40:3421–8. https://doi.org/10.1016/j.clnu.2020.11.020.

Article  CAS  PubMed  Google Scholar 

Ee C, Cave A, Vaddiparthi V, Naidoo D, Boyages J. Factors associated with weight gain after breast cancer: Results from a community-based survey of Australian women. Breast. 2023;69:491–8. https://doi.org/10.1016/j.breast.2023.01.012.

Article  PubMed  PubMed Central  Google Scholar 

Sestak I, Harvie M, Howell A, Forbes JF, Dowsett M, Cuzick J. Weight change associated with anastrozole and tamoxifen treatment in postmenopausal women with or at high risk of developing breast cancer. Breast Cancer Res Treat. 2012;134:727–34. https://doi.org/10.1007/s10549-012-2085-6.

Article  CAS  PubMed  Google Scholar 

Boszkiewicz K, Piwowar A, Petryszyn P. Aromatase Inhibitors and Risk of Metabolic and Cardiovascular Adverse Effects in Breast Cancer Patients-A Systematic Review and Meta-Analysis. J Clin Med. 2022;11:3133. https://doi.org/10.3390/jcm11113133.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nyrop KA, Williams GR, Muss HB, Shachar SS. Weight gain during adjuvant endocrine treatment for early-stage breast cancer: What is the evidence? Breast Cancer Res Treat. 2016;158:203–17. https://doi.org/10.1007/s10549-016-3874-0.

Article  CAS  PubMed  Google Scholar 

Chan DSM, Vieira AR, Aune D, Bandera EV, Greenwood DC, McTiernan A, et al. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol. 2014;25:1901–14. https://doi.org/10.1093/annonc/mdu042.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pang Y, Wei Y, Kartsonaki C. Associations of adiposity and weight change with recurrence and survival in breast cancer patients: a systematic review and meta-analysis. Breast Cancer Tokyo Japan. 2022;29:575–88. https://doi.org/10.1007/s12282-022-01355-z.

Article  PubMed  PubMed Central  Google Scholar 

Ewertz M, Jensen M-B, Gunnarsdóttir KÁ, Højris I, Jakobsen EH, Nielsen D, et al. Effect of obesity on prognosis after early-stage breast cancer. J Clin Oncol. 2011;29:25–31. https://doi.org/10.1200/JCO.2010.29.7614.

Article  PubMed  Google Scholar 

Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. J Natl Cancer Inst. 2015;107:djv275. https://doi.org/10.1093/jnci/djv275.

Article  PubMed  PubMed Central  Google Scholar 

Blüher M. An overview of obesity-related complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes. Diabetes, Obesity and Metabolism. Volume 27. John Wiley & Sons, Ltd; 2025. pp. 3–19. https://doi.org/10.1111/dom.16263.

Hershman DL, Till C, Shen S, Wright JD, Ramsey SD, Barlow WE, et al. Association of Cardiovascular Risk Factors With Cardiac Events and Survival Outcomes Among Patients With Breast Cancer Enrolled in SWOG Clinical Trials. J Clin Oncol. 2018;36:2710–7. https://doi.org/10.1200/JCO.2017.77.4414.

Article  PubMed  PubMed Central  Google Scholar 

Pfeiler G, Königsberg R, Fesl C, Mlineritsch B, Stoeger H, Singer CF, et al. Impact of body mass index on the efficacy of endocrine therapy in premenopausal patients with breast cancer: an analysis of the prospective ABCSG-12 trial. J Clin Oncol. 2011;29:2653–9. https://doi.org/10.1200/JCO.2010.33.2585.

Article  CAS  PubMed  Google Scholar 

Sestak I, Distler W, Forbes JF, Dowsett M, Howell A, Cuzick J. Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial. J Clin Oncol. 2010;28:3411–5. https://doi.org/10.1200/JCO.2009.27.2021.

Article  CAS  PubMed  Google Scholar 

Desmedt C, Fornili M, Clatot F, Demicheli R, De Bortoli D, Di Leo A, et al. Differential Benefit of Adjuvant Docetaxel-Based Chemotherapy in Patients With Early Breast Cancer According to Baseline Body Mass Index. J Clin Oncol. 2020;38:2883–91. https://doi.org/10.1200/JCO.19.01771.