AD-REAL: A Prospective, Multinational, Observational Cohort Study of Clinical Effectiveness and Treatment Discontinuation of Oral Systemics for Moderate-to-Severe Atopic Dermatitis

Bieber T, D’Erme AM, Akdis CA, Traidl-Hoffmann C, Lauener R, Schäppi G, et al. Clinical phenotypes and endophenotypes of atopic dermatitis: where are we, and where should we go? J Allergy Clin Immunol. 2017;139(4s):S58-s64.

Article  PubMed  Google Scholar 

Kowalska-Olędzka E, Czarnecka M, Baran A. Epidemiology of atopic dermatitis in Europe. J Drug Assess. 2019;8(1):126–8.

Article  PubMed  PubMed Central  Google Scholar 

Wollenberg A, Kinberger M, Arents B, Aszodi N, Avila Valle G, Barbarot S, et al. European guideline (EuroGuiDerm) on atopic eczema: part I—systemic therapy. J Eur Acad Dermatol Venereol. 2022;36(9):1409–31.

Article  PubMed  CAS  Google Scholar 

Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32(5):657–82.

Article  PubMed  CAS  Google Scholar 

Eckert L, Gupta S, Gadkari A, Mahajan P, Gelfand JM. Burden of illness in adults with atopic dermatitis: analysis of National Health and wellness survey data from France, Germany, Italy, Spain, and the United Kingdom. J Am Acad Dermatol. 2019;81(1):187–95.

Article  PubMed  Google Scholar 

Talamonti M, Galluzzo M, Silvaggio D, Lombardo P, Tartaglia C, Bianchi L. Quality of life and psychological impact in patients with atopic dermatitis. J Clin Med. 2021. https://doi.org/10.3390/jcm10061298.

Article  PubMed  PubMed Central  Google Scholar 

Augustin M, Langenbruch A, Blome C, Gutknecht M, Werfel T, Ständer S, et al. Characterizing treatment-related patient needs in atopic eczema: insights for personalized goal orientation. J Eur Acad Dermatol Venereol. 2020;34(1):142–52.

Article  PubMed  CAS  Google Scholar 

Renert-Yuval Y, Thyssen JP, Bissonnette R, Bieber T, Kabashima K, Hijnen D, et al. Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council. J Allergy Clin Immunol. 2021;147(4):1174-90.e1.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ramírez-Marín HA, Silverberg JI. Differences between pediatric and adult atopic dermatitis. Pediatr Dermatol. 2022;39(3):345–53.

Article  PubMed  Google Scholar 

Wollenberg A, Kinberger M, Arents B, Aszodi N, Barbarot S, Bieber T, et al. European guideline (EuroGuiDerm) on atopic eczema: living update. J Eur Acad Dermatol Venereol. 2025. https://doi.org/10.1111/jdv.20639.

Article  PubMed  PubMed Central  Google Scholar 

Bieber T, Straeter B. Off-label prescriptions for atopic dermatitis in Europe. Allergy. 2015;70(1):6–11.

Article  PubMed  CAS  Google Scholar 

Moyle M, Cevikbas F, Harden JL, Guttman-Yassky E. Understanding the immune landscape in atopic dermatitis: the era of biologics and emerging therapeutic approaches. Exp Dermatol. 2019;28(7):756–68.

Article  PubMed  PubMed Central  Google Scholar 

Augustin M, Serra-Baldrich E, Seneschal J, Grond S, Lampropoulou A, Elrayes M, et al. Baseline characteristics and treatment patterns of patients with atopic dermatitis treated with oral systemic therapies: an interim analysis of the AD-REAL study. Adv Ther. 2025. https://doi.org/10.1007/s12325-025-03137-3.

Article  PubMed  PubMed Central  Google Scholar 

Davis DMR, Frazer-Green L, Alikhan A, Bercovitch L, Cohen DE, Darr JM, et al. Focused update: guidelines of care for the management of atopic dermatitis in adults. J Am Acad Dermatol. 2025. https://doi.org/10.1016/j.jaad.2025.05.1386.

Article  PubMed  PubMed Central  Google Scholar 

Haag C, Alexis A, Aoki V, et al. A practical guide to using oral Janus kinase inhibitors for atopic dermatitis from the International Eczema Council. Br J Dermatol. 2025;192(1):135–43. https://doi.org/10.1093/bjd/ljae342.

Article  Google Scholar 

de Bruin-Weller M, Pink AE, Ferrucci SM, Patrizi A, Svensson A, Schuttelaar MLA, et al. Use of systemic therapies in adults with atopic dermatitis: 12-month results from the European prospective observational study in patients eligible for systemic therapy for atopic dermatitis (EUROSTAD). J Dermatolog Treat. 2022;33(5):2565–70.

Article  PubMed  Google Scholar 

Alexander H, Malek R, Prieto-Merino D, Gribaleva E, Baden M, Beattie P, et al. A prospective observational cohort study comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic dermatitis: results from the UK–Irish A-STAR register. Br J Dermatol. 2024;191(6):988–99.

Article  PubMed  Google Scholar 

Gargiulo L, Ibba L, Cortese A, Avagliano J, Valenti M, Costanzo A, et al. Real-life effectiveness and safety of Upadacitinib in adults and adolescents with moderate-to-severe atopic dermatitis: a single-center 16-week study. Dermatol Ther (Heidelb). 2023;13(2):651–60.

Article  PubMed  PubMed Central  Google Scholar 

Silverberg JI, Simpson EL, Thyssen JP, Gooderham M, Chan G, Feeney C, et al. Efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2020;156(8):863–73.

Article  PubMed  PubMed Central  Google Scholar 

Simpson EL, Bieber T, Guttman-Yassky E, Beck LA, Blauvelt A, Cork MJ, et al. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med. 2016;375(24):2335–48.

Article  PubMed  CAS  Google Scholar 

Silverberg JI, Simpson EL, Wollenberg A, Bissonnette R, Kabashima K, DeLozier AM, et al. Long-term efficacy of baricitinib in adults with moderate to severe atopic dermatitis who were treatment responders or partial responders: an extension study of 2 randomized clinical trials. JAMA Dermatol. 2021;157(6):691–9.

Article  PubMed  PubMed Central  Google Scholar 

Costanzo A, Amerio P, Asero R, Chiricozzi A, Corazza M, Cristaudo A, et al. Long-term management of moderate-to-severe adult atopic dermatitis: a consensus by the Italian Society of Dermatology and Venereology (SIDeMaST), the Association of Italian Territorial and Hospital Allergists and Immunologists (AAIITO), the Italian Association of Hospital Dermatologists (ADOI), the Italian Society of Allergological, Environmental and Occupational Dermatology (SIDAPA), and the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). Ital J Dermatol Venerol. 2022;157(1):1–12.

PubMed  Google Scholar 

Reguiai Z, Becherel PA, Perrot JL, Fougerousse AC, Begon E, Poreaux C, et al. Impact of baricitinib on patients’ quality of life after one year of treatment for atopic dermatitis in real-world practice: results of the observatory of chronic inflammatory skin diseases registry. Acta Derm Venereol. 2023;103:adv14153.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Eckert L, Gupta S, Amand C, Gadkari A, Mahajan P, Gelfand JM. The burden of atopic dermatitis in US adults: health care resource utilization data from the 2013 National Health and Wellness Survey. J Am Acad Dermatol. 2013;78(1):54-61.e1.

Article  Google Scholar 

Simpson EL, Guttman-Yassky E, Margolis DJ, Feldman SR, Qureshi A, Hata T, et al. Association of inadequately controlled disease and disease severity with patient-reported disease burden in adults with atopic dermatitis. JAMA Dermatol. 2018;154(8):903–12.

Article  PubMed  PubMed Central  Google Scholar 

Lio PA, Wollenberg A, Thyssen JP, Pierce EJ, Rueda MJ, DeLozier AM, et al. Impact of atopic dermatitis lesion location on quality of life in adult patients in a real-world study. J Drugs Dermatol. 2020;19(10):943–8.

Article  PubMed  Google Scholar 

Soria A, Thénié C, Bienenfeld C, Staumont-Sallé D. General burden of adult atopic dermatitis: an observational study of disease perceptions among patients and dermatologists in France. Acta Derm Venereol. 2021;101(11):adv00588.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Katoh N, Saeki H, Kataoka Y, Etoh T, Teramukai S, Takagi H, et al. Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS-J): baseline characteristics, treatment history and disease burden. J Dermatol. 2019;46(4):290–300.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Legat FJ. Itch in atopic dermatitis—What is new? Front Med (Lausanne). 2021;8:644760.

Article  PubMed  PubMed Central  Google Scholar 

Carrascosa JM, Narcisi A, Nomura T, Ständer S, Vestergaard C, Sabatino S, et al. Baricitinib improvement across regions in atopic dermatitis patients with baseline body surface area up to 40% and severe itch. Dermatol Ther. 2024;14(6):1561–73.

Comments (0)

No login
gif