Jonathan I. Silverberg: Has received honoraria as a consultant and/or advisory board member for AbbVie, Aldena, Amgen, AObiome, Apollo, Arcutis, Arena, Asana, Aslan, Attovia, Bodewell, Boehringer Ingelheim, Bristol Myers Squibb, Cara, Castle Biosciences, Celgene, Connect Biopharma, CorEvitas, Dermavant, Eli Lilly, FIDE, Galderma, GlaxoSmithKline, Incyte, Inmagene, Invea, Kiniksa, LEO Pharma, Merck, Nektar, Novartis, Optum, Pfizer, RAPT, Recludix, Regeneron, Sandoz, Sanofi Genzyme, Shaperon, TARGET-RWE, Teva, Triveni, Union, and UpToDate; speaker for AbbVie, Arcutis, Dermavant, Eli Lilly, Galderma, LEO Pharma, Pfizer, Regeneron, and Sanofi Genzyme; institution received grants from Galderma, Incyte, and Pfizer. Vimal H. Prajapati: Advisor, consultant, and/or speaker for: AbbVie, Actelion, Amgen, Apogee Therapeutics, Aralez, Arcutis, Aspen, Bausch Health, BioJAMP/JAMP Pharma, BioScript Solutions, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Celltrion, Cipher, CorEvitas, Eli Lilly, Galderma, GlaxoSmithKline, Homeocan, Incyte, Janssen, Johnson & Johnson, Johnson & Johnson Innovative Medicine, Kenvue, LEO Pharma, Medexus, Novartis, Organon, Paladin, Pediapharm, Pfizer, Regeneron, Sanofi Genzyme, Sun Pharmaceuticals, Tribute, and UCB; investigator for: AbbVie, AnaptysBio, Apogee Therapeutics, Arcutis, Arena, Asana, Bausch Health, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Concert, CorEvitas, Dermavant, Dermira, Eli Lilly, Galderma, Incyte, Janssen, Johnson & Johnson Innovative Medicine, LEO Pharma, Nektar Therapeutics, Nimbus Lakshmi, Novartis, Pfizer, RAPT Therapeutics, Regeneron, Reistone, Roche, Sanofi Genzyme, Sun Pharmaceuticals, Takeda, UCB, and Vyne Therapeutics; received grants from: AbbVie, Bausch Health, Janssen, LEO Pharma, Novartis, and Sanofi Genzyme. Susanne Abraham: Susanne Abraham has served as a consultant, lecturer, researcher, and/or has received research grants from AbbVie, Amgen, BMS, Beiersdorf, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Sanofi, Takeda, and UCB. Alan D. Irvine: Is a consultant and/or speaker for AbbVie, Arena, BenevolentAI, Chugai Pharma, Eli Lilly, Genentech, Janssen, Novartis, Regeneron, Sanofi Genzyme, and Pfizer. Melinda J. Gooderham: Has served as an advisor, speaker, and/or consultant for AbbVie, Akros Pharma Inc., Amgen, Arena, Arcutis, Asana BioSciences, AnaptysBio, Aristea, Bausch Health, Boehringer Ingelheim International, Bristol Myers Squibb, Celgene, Coherus Biosciences, Dermavant, Dermira, Eli Lilly, Galderma SA., GSK, Incyte, Janssen, Kyowa Kirin, LEO Pharma, MedImmune, Merck, Meiji, Moonlake, Novartis, Nimbus Therapeutics, Pfizer, Regeneron, Reistone, Sanofi Genzyme, Sun Pharmaceuticals, and UCB; and support for attending meetings from AbbVie, Amgen, Arcutis, Bristol Myers Squibb, Eli Lilly, Janssen, LEO Pharma, Pfizer, Sanofi Genzyme, and UCB. Emma Guttman-Yassky: Employee of Mount Sinai and has received research funds (grants paid to her institution) from AbbVie, Almirall, Amgen, AnaptysBio, Asana BioSciences, AstraZeneca, Boehringer Ingelheim, Cara Therapeutics, Celgene, Eli Lilly, Galderma, Glenmark/Ichnos Sciences, Innovaderm, Janssen, KAO, Kiniksa, Kyowa Kirin, LEO Pharma, Novan, Novartis, Pfizer, Ralexar, Regeneron, and UCB; is a consultant for AbbVie, Almirall, Amgen, Arena, Asana BioSciences, Aslan, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Cara Therapeutics, Celgene, Connect Pharma, Eli Lilly, EMD Serono, Evidera, Galderma, Ichnos Sciences, Incyte, Janssen Biotech, Kyowa Kirin, LEO Pharma, Pandion Therapeutics, Pfizer, RAPT Therapeutics, Regeneron, Sanofi, SATO Pharmaceutical, Siolta Therapeutics, Target Pharma Solutions, UCB, and Ventyx Biosciences. Hideaki Tanizaki: Has received honoraria from AbbVie, Eli Lilly, Janssen, Kyowa Kirin, Maruho, Sanofi, Sun Pharmaceuticals, and Torii; has received contract research and collaborative research funding from Maruho and Sun Pharmaceuticals; has received scholarship donations from Maruho, Sun Pharmaceuticals, and Torii. Marius Rademaker: Investigator at AbbVie, Akesio, Aslan, Boehringer Ingelheim, Botanix, Douglas, Galderma, Hexima, and Suzhou Connect. Kilian Eyerich: Has received grants and honoraria from, and has served as a speaker, investigator, consultant and/or advisor for AbbVie, Almirall, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Eli Lilly, Galapagos, Galderma, Hexal, Janssen, Novartis, Pfizer, Sanofi, and UCB. Alvaro Moreira, Wan-Ju Lee: Current or former employees of AbbVie who may hold stock and/or stock options in the company. Richard Ta: Is a contractor of AbbVie. Shirley H. Chen: Is a full-time, salaried employee of Tigermed-BDM Inc., which provided statistical analysis support that was funded by AbbVie.

The independent ethics committee or institutional review board at each study site approved the study protocol, informed consent forms, and recruitment materials before patient enrollment. The studies were conducted in accordance with the International Conference for Harmonisation guidelines, applicable regulations, and the Declaration of Helsinki. All patients provided written informed consent to participate in the study and for publication before screening.