Effects of Potassium on Swallowing Performance in Healthy Humans

Jean A. Brain stem control of swallowing: neuronal network and cellular mechanisms. Physiol Rev. 2001;81:929–69.

Article  CAS  PubMed  Google Scholar 

Miller AJ. Deglutition. Physiol Rev. 1982;62:129–84.

Article  CAS  PubMed  Google Scholar 

Kitada Y, Yahagi R, Okuda-Akabane K. Effect of stimulation of the laryngopharynx with water and salt solutions on voluntary swallowing in humans: characteristics of water receptors in the laryngopharyngeal mucosa. Chem Senses. 2010;35:743–9.

Article  CAS  PubMed  Google Scholar 

Tsukano H, Taniguchi H, Hori K, Tsujimura T, Nakamura Y, Inoue M. Individual-dependent effects of pharyngeal electrical stimulation on swallowing in healthy humans. Physiol Behav. 2012;106:218–23.

Article  CAS  PubMed  Google Scholar 

Teramoto S, Yamamoto H, Yamaguchi Y, Hanaoka Y, Ishii M, Hibi S, et al. Lower respiratory tract infection outcomes are predicted better by an age >80 years than by CURB-65. Eur Respir J. 2008;31:477–8.

Article  CAS  PubMed  Google Scholar 

Teramoto S, Fukuchi Y, Sasaki H, Sato K, Sekizawa K, Matsuse T. High incidence of aspiration pneumonia in community- and hospital-acquired pneumonia in hospitalized patients: a multicenter, prospective study in Japan. J Am Geriatr Soc. 2008;56:577–9.

Article  PubMed  Google Scholar 

Ondetti MA, Williams NJ, Sabo EF, Pluscec J, Weaver ER, Kocy O. Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis. Biochemistry. 1971;10:4033–9.

Article  CAS  PubMed  Google Scholar 

Couture R, Regoli D. Inactivation of substance P and its C-terminal fragments in rat plasma and its inhibition by Captopril. Can J Physiol Pharmacol. 1981;59:621–5.

Article  CAS  PubMed  Google Scholar 

Skidgel RA, Engelbrecht S, Johnson AR, Erdös EG. Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase. Peptides. 1984;5:769–76.

Article  CAS  PubMed  Google Scholar 

Yamaya M, Yanai M, Ohrui T, Arai H, Sasaki H. Interventions to prevent pneumonia among older adults. J Am Geriatr Soc. 2001;49:85–90.

Article  CAS  PubMed  Google Scholar 

Ebihara T, Sekizawa K, Nakazawa H, Sasaki H. Capsaicin and swallowing reflex. Lancet. 1993;341:432.

Article  CAS  PubMed  Google Scholar 

Nakagawa T, Ohrui T, Sekizawa K, Sasaki H. Sputum substance P in aspiration pneumonia. Lancet. 1995;345:1447.

Article  CAS  PubMed  Google Scholar 

Ebihara T, Ebihara S, Watando A, Okazaki T, Asada M, Ohrui T, et al. Effects of menthol on the triggering of the swallowing reflex in elderly patients with dysphagia. Br J Clin Pharmacol. 2006;62:369–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shingai T. Ionic mechanism of water receptors in the laryngeal mucosa of the rabbit. Jpn J Physiol. 1977;27:27–42.

Article  CAS  PubMed  Google Scholar 

Storey AT. Laryngeal initiation of swallowing. Exp Neurol. 1968;20:359–65.

Article  CAS  PubMed  Google Scholar 

Storey AT. A functional analysis of sensory units innervating epiglottis and larynx. Exp Neurol. 1968;20:366–83.

Article  CAS  PubMed  Google Scholar 

Boggs DF, Bartlett D Jr. Chemical specificity of a laryngeal apneic reflex in puppies. J Appl Physiol. 1982;53:455–62.

Article  CAS  PubMed  Google Scholar 

Shingai T, Miyaoka Y, Ikarashi R, Shimada K. Swallowing reflex elicited by water and taste solutions in humans. Am J Physiol. 1989;256:R822-826.

CAS  PubMed  Google Scholar 

Yahagi R, Okuda-Akabane K, Fukami H, Matsumoto N, Kitada Y. Facilitation of voluntary swallowing by chemical stimulation of the posterior tongue and pharyngeal region in humans. Neurosci Lett. 2008;448:139–42.

Article  CAS  PubMed  Google Scholar 

Kawada S, Chotirungsan T, Pan CR, Tsutsui Y, Okamoto K, Magara J, et al. Effects of potassium on laryngeal-induced swallowing rate in rats. Am J Physiol Gastrointest Liver Physiol. 2025;328:G502-g512.

Article  CAS  PubMed  Google Scholar 

Bradley RM, Stedman HM, Mistretta CM. Superior laryngeal nerve response patterns to chemical stimulation of sheep epiglottis. Brain Res. 1983;276:81–93.

Article  CAS  PubMed  Google Scholar 

Shingai T. Water fibers in the superior laryngeal nerve of the rat. Jpn J Physiol. 1980;30:305–7.

Article  CAS  PubMed  Google Scholar 

Pouderoux P, Logemann JA, Kahrilas PJ. Pharyngeal swallowing elicited by fluid infusion: role of volition and vallecular containment. Am J Physiol. 1996;270:G347-354.

CAS  PubMed  Google Scholar 

Nakamura Y, Hatakeyama A, Kitada Y, Tsujimura T, Taniguchi H, Inoue M. Effects of pharyngeal water stimulation on swallowing behaviors in healthy humans. Exp Brain Res. 2013;230:197–205.

Article  PubMed  Google Scholar 

Kern MK, Birn RM, Jaradeh S, Jesmanowicz A, Cox RW, Hyde JS, et al. Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention. Gastroenterology. 1998;115:1353–62.

Article  CAS  PubMed  Google Scholar 

Kern MK, Shaker R. Cerebral cortical registration of subliminal visceral stimulation. Gastroenterology. 2002;122:290–8.

Article  PubMed  Google Scholar 

Dehaene S, Naccache L, Le Clec HG, Koechlin E, Mueller M, Dehaene-Lambertz G, et al. Imaging unconscious semantic priming. Nature. 1998;395:597–600.

Article  CAS  PubMed  Google Scholar 

Miyaoka Y, Haishima K, Takagi M, Haishima H, Asari J, Yamada Y. Influences of thermal and gustatory characteristics on sensory and motor aspects of swallowing. Dysphagia. 2006;21:38–48.

Article  PubMed  Google Scholar 

Mistry S, Rothwell JC, Thompson DG, Hamdy S. Modulation of human cortical swallowing motor pathways after pleasant and aversive taste stimuli. Am J Physiol Gastrointest Liver Physiol. 2006;291:G666-671.

Article  CAS  PubMed  Google Scholar 

Prescott SL, Umans BD, Williams EK, Brust RD, Liberles SD. An airway protection program revealed by sweeping genetic control of vagal afferents. Cell. 2020;181:574-589.e514.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soma S, Hayatsu N, Nomura K, Sherwood MW, Murakami T, Sugiyama Y, et al. Channel synapse mediates neurotransmission of airway protective chemoreflexes. Cell. 2025;188:2687-2704.e2629.

Article  CAS  PubMed  Google Scholar 

Ali GN, Laundl TM, Wallace KL, deCarle DJ, Cook IJ. Influence of cold stimulation on the normal pharyngeal swallow response. Dysphagia. 1996;11:2–8.

Article  CAS 

Comments (0)

No login
gif