Mármol I, et al. Colorectal carcinoma: a general overview and future perspectives in colorectal cancer. Int J Mol Sci. 2017;18(1):197.

Article  PubMed  PubMed Central  Google Scholar 

Center MM, Jemal A, Smith RA, Ward E. Worldwide variations in colorectal cancer. CA Cancer J Clin. 2009;59(6):366–78.

Article  PubMed  Google Scholar 

Kuipers EJ, et al. Colorectal cancer. Nat Rev Dis Primers. 2015;1:15065.

Article  PubMed  PubMed Central  Google Scholar 

Morgan E, et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut. 2023;72(2):338–44.

Article  PubMed  Google Scholar 

Ciemins EL, et al. Development of a follow-up measure to ensure complete screening for colorectal cancer. JAMA Netw Open. 2024;7(3):e242693–e242693.

Article  PubMed  PubMed Central  Google Scholar 

Koveitypour Z, et al. Signaling pathways involved in colorectal cancer progression. Cell Biosci. 2019;9:1–14.

Article  Google Scholar 

Wierzbicki PM, Rybarczyk A. The Hippo pathway in colorectal cancer. Folia Histochem Cytobiol. 2015;53(2):105–19.

Article  CAS  PubMed  Google Scholar 

Gao WL, Ye GC, Liu LW, Wei L. The downregulation of Rap1 GTPase-activating protein is associated with a poor prognosis in colorectal cancer and may impact on tumor progression. Oncol Lett. 2018;15(5):7661–8.

PubMed  PubMed Central  Google Scholar 

Farooqi AA, De La Roche M, Djamgoz MB, Siddik ZH. Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights. Semin Cancer Biol. 2019. https://doi.org/10.1016/j.semcancer.2019.01.001.

Article  PubMed  Google Scholar 

Markowitz SD, Bertagnolli MM. Molecular basis of colorectal cancer. N Engl J Med. 2009;361(25):2449–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song R, et al. Functional significance of Hippo/YAP signaling for drug resistance in colorectal cancer. Mol Carcinog. 2018;57(11):1608–15.

Article  CAS  PubMed  Google Scholar 

Liang K, et al. Expression of hippo pathway in colorectal cancer. Saudi J Gastroenterol: Off J Saudi Gastroenterol Assoc. 2014;20(3):188.

Article  Google Scholar 

Zhang YL, et al. Roles of Rap1 signaling in tumor cell migration and invasion. Cancer Biol Med. 2017;14(1):90–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L, et al. High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway. J Exp Clin Cancer Res. 2018;37(1):178.

Article  PubMed  PubMed Central  Google Scholar 

Abbastabar M, et al. Expression status of Rap1 pathway-related genes in liver metastases compared with corresponding primary colorectal cancer. Cancers. 2023;16(1):171.

Article  PubMed  PubMed Central  Google Scholar 

Sharma R, Gescher A, Steward W. Curcumin: the story so far. Eur J Cancer. 2005;41(13):1955–68.

Article  CAS  PubMed  Google Scholar 

Lestari ML, Indrayanto G. Curcumin. Prof Drug Subst Excip Relat Methodol. 2014;39:113–204.

Article  CAS  Google Scholar 

Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23(1/A):363–98.

CAS  PubMed  Google Scholar 

Ye C, et al. A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo–YAP signaling pathway. OncoTargets Ther. 2019;12:2259–69.

Article  CAS  Google Scholar 

Okuno K, et al. Berberine overcomes gemcitabine-associated chemoresistance through regulation of Rap1/PI3K-Akt signaling in pancreatic ductal adenocarcinoma. Pharmaceuticals. 2022;15(10):1199.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sabates-Bellver J, et al. Transcriptome profile of human colorectal adenomas. Mol Cancer Res. 2007;5(12):1263–75.

Article  CAS  PubMed  Google Scholar 

Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherman BT, et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216-w221.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Potter JD. Colorectal cancer: molecules and populations. J Natl Cancer Inst. 1999;91(11):916–32.

Article  CAS  PubMed  Google Scholar 

Marley AR, Nan H. Epidemiology of colorectal cancer. Int J Mole Epidemiol Genet. 2016;7(3):105.

Google Scholar 

Fearon ER. Molecular genetics of colorectal cancer. Annu Rev Pathol. 2011;6:479–507.

Article  CAS  PubMed  Google Scholar 

Korkmaz G, et al. LGALS3 and AXIN1 gene variants playing role in the Wnt/ β-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer. Bosn J Basic Med Sci. 2016;16(2):108–13.

CAS  PubMed  PubMed Central  Google Scholar 

Koinuma K, et al. Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. Oncogene. 2006;25(1):139–46.

Article  CAS  PubMed  Google Scholar 

Kim DU, Nam J, Cha MD, Kim SW. Inhibition of phosphodiesterase 4D decreases the malignant properties of DLD-1 colorectal cancer cells by repressing the AKT/mTOR/Myc signaling pathway. Oncol Lett. 2019;17(3):3589–98.

CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, et al. Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner. Oncogene. 2016;35(21):2789–800.

Article  CAS  PubMed  Google Scholar 

Yu SJ, et al. SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer. World J Gastroenterol. 2011;17(15):2028–36.

Article  PubMed  PubMed Central  Google Scholar 

Harvey KF, Zhang X, Thomas DM. The Hippo pathway and human cancer. Nat Rev Cancer. 2013;13(4):246–57.

Article  CAS  PubMed  Google Scholar 

Han Y. Analysis of the role of the Hippo pathway in cancer. J Transl Med. 2019;17(1):116.

Article  PubMed  PubMed Central  Google Scholar 

Chan SW, et al. The Hippo pathway in biological control and cancer development. J Cell Physiol. 2011;226(4):928–39.

Article  CAS  PubMed