Li W, Wu C, Qin M, Cai F, Huang J. The aura of malignant tumor: clinical analysis of malignant tumor-related pyogenic liver abscess. Med. 2020;99(9):e19282. https://doi.org/10.1097/md.0000000000019282.

Article  Google Scholar 

Youssef MA, Al-Sharif H, McGrath BT, Picken MM, Le Poole IC. Benign tumors broaden the field of application for immunotherapy. Front Immunol. 2025;16:1593960. https://doi.org/10.3389/fimmu.2025.1593960.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Muscat JE. Trends in malignant and benign brain tumor incidence and mobile phone use in the U.S. (2000–2021): a SEER-based study. Int J Environ Res Public Health. 2025. https://doi.org/10.3390/ijerph22060933.

Article  PubMed  PubMed Central  Google Scholar 

Sufianova G, Gareev I, Beylerli O, Wu J, Shumadalova A, Sufianov A, et al. Modern aspects of the use of natural polyphenols in tumor prevention and therapy. Front Cell Dev Biol. 2022;10:1011435. https://doi.org/10.3389/fcell.2022.1011435.

Article  PubMed  PubMed Central  Google Scholar 

Sun Y, Xu L, Cai Q, Wang M, Wang X, Wang S, et al. Research progress on the pharmacological effects of matrine. Front Neurosci. 2022;16:977374. https://doi.org/10.3389/fnins.2022.977374.

Article  PubMed  PubMed Central  Google Scholar 

Zimmermann-Klemd AM, Reinhardt JK, Winker M, Gründemann C. Phytotherapy in integrative oncology-an update of promising treatment options. Molecules. 2022. https://doi.org/10.3390/molecules27103209.

Article  PubMed  PubMed Central  Google Scholar 

Huang X, Li S, Ding R, Li Y, Li C, Gu R. Antitumor effects of polysaccharides from medicinal lower plants: a review. Int J Biol Macromol. 2023;252:126313. https://doi.org/10.1016/j.ijbiomac.2023.126313.

Article  CAS  PubMed  Google Scholar 

Munir S, Shah AA, Shahid M, Ahmed MS, Shahid A, Rajoka MSR, et al. Anti-angiogenesis potential of phytochemicals for the therapeutic management of tumors. Curr Pharm Des. 2020;26(2):265–78. https://doi.org/10.2174/1381612826666191230142638.

Article  CAS  PubMed  Google Scholar 

Chang CC, Li HJ, Satange R, Lin SM, Chen TL, Lin CC, et al. Structural and functional insights into targeting GCCG sites in the EGFR promoter by two DNA intercalators to inhibit breast cancer metastasis. J Med Chem. 2025;68(6):6601–15. https://doi.org/10.1021/acs.jmedchem.4c03203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gurova KV. Chromatin stability as a target for cancer treatment. Bioessays. 2019;41(1):e1800141. https://doi.org/10.1002/bies.201800141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Almeida LC, Calil FA, Machado-Neto JA, Costa-Lotufo LV. DNA damaging agents and DNA repair: from carcinogenesis to cancer therapy. Cancer Genet. 2021;252:6–24. https://doi.org/10.1016/j.cancergen.2020.12.002.

Article  CAS  PubMed  Google Scholar 

Lian Z, Tai Y, Xia H, Zhai H. QSAR study of novel 1, 8-naphthimide derivatives targeting nuclear DNA. Anticancer Agents Med Chem. 2023;23(6):726–33. https://doi.org/10.2174/1871520622666220822010953.

Article  CAS  PubMed  Google Scholar 

Hasan NK, Mahmoud Z, Kandeel MM, Soliman AAF, El-Khouly EA. Novel 2,6-Bis(indolyl/ 5-bromoindolyl)dihydropyridine/pyridine hybrids as potential anti-tumor agents: design, one-pot green synthesis, molecular docking, and cytotoxicity evaluation. Bioorg Chem. 2025;166:109058. https://doi.org/10.1016/j.bioorg.2025.109058.

Article  CAS  PubMed  Google Scholar 

Gao C, Wang W, Yu Y, Wu J. Design, synthesis, and biological evaluation of phenylsulfonylfuroxan-β-carboline-hydroxamic acid ternary hybrids for cancer. Eur J Med Chem. 2025;300:118157. https://doi.org/10.1016/j.ejmech.2025.118157.

Article  CAS  PubMed  Google Scholar 

Dubey R, Gupta S, Singh R, Chandel S, Thakur S, Irani M, et al. Triazole-pyrimidine hybrids as EGFR inhibitors via synthesis, in silico, in vitro, and in vivo evaluation as anticancer agents. Drug Dev Res. 2025;86(6):e70154. https://doi.org/10.1002/ddr.70154.

Article  CAS  PubMed  Google Scholar 

Shalini P, Saha ST, Kaur M, Oluwakemi E, Awolade P, et al. Synthesis and in vitro anti-proliferative evaluation of naphthalimide-chalcone/pyrazoline conjugates as potential serms with computational validation. RSC Adv. 2020;10(27):15836–45. https://doi.org/10.1039/d0ra01822h.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kloeber JA, Lou Z. Critical DNA damaging pathways in tumorigenesis. Semin Cancer Biol. 2022;85:164–84. https://doi.org/10.1016/j.semcancer.2021.04.012.

Article  CAS  PubMed  Google Scholar 

Souza AG, Bastos VAF, Fujimura PT, Ferreira ICC, Leal LF, da Silva LS, et al. Cell-free DNA promotes malignant transformation in non-tumor cells. Sci Rep. 2020;10(1):21674. https://doi.org/10.1038/s41598-020-78766-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papanicolau-Sengos A, Singh O, Park K, Snuderl M, Tretiakova M, Merino M, et al. DNA methylation-based classification of kidney neoplasms. Mod Pathol. 2025;100884. https://doi.org/10.1016/j.modpat.2025.100884.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan D, Wang Q, Shen A, Qi Z, Zheng C, Hu B. When DNA damage responses meet tumor immunity: from mechanism to therapeutic opportunity. Int J Cancer. 2024;155(3):384–99. https://doi.org/10.1002/ijc.34954.

Article  CAS  PubMed  Google Scholar 

Yildiz U, Coban B. Novel naphthalimide derivatives as selective G-quadruplex DNA binders. Appl Biochem Biotechnol. 2018;186(3):547–62. https://doi.org/10.1007/s12010-018-2749-8.

Article  CAS  PubMed  Google Scholar 

Zhang HY, Han LL, Wu HY, Xu XX, Yu MB, Chen GY, et al. Research progress on structure-activity relationship of 1,8-naphthalimide DNA chimeras against tumor. Technol Cancer Res Treat. 2024;23:15330338231225861. https://doi.org/10.1177/15330338231225861.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang K, Wang L, Shang Z, Yang X, Li H, Wang X, et al. A series of DNA targeted Cu (II) complexes containing 1,8-naphthalimide ligands: synthesis, characterization and in vitro anticancer activity. J Inorg Biochem. 2024;261:112721. https://doi.org/10.1016/j.jinorgbio.2024.112721.

Article  CAS  PubMed  Google Scholar 

Ge C, Liu L, Wang Y, Di X, Luo X, Liu H, et al. Novel 1,8-naphthalimide derivatives as antitumor agents and potent demethylase inhibitors. ACS Med Chem Lett. 2023;14(11):1551–7. https://doi.org/10.1021/acsmedchemlett.3c00353.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruan W, Xie Z, Wang Y, Xia L, Guo Y, Qiao D. An overview of naphthylimide as specific scaffold for new drug discovery. Molecules. 2024. https://doi.org/10.3390/molecules29194529.

Article  PubMed  PubMed Central  Google Scholar 

Tandon R, Luxami V, Kaur H, Tandon N, Paul K. 1,8-naphthalimide: a potent DNA intercalator and target for cancer therapy. Chem Rec. 2017;17(10):956–93. https://doi.org/10.1002/tcr.201600134.

Article  CAS  PubMed  Google Scholar 

Shen G, Li S, Zhu Y, Xu Z, Liu X, Lv C, et al. Recent progress in topoisomerase inhibitors as anticancer agents: research and design strategies for Topo I and II inhibitors via structural optimization. Bioorg Chem. 2025;165:109040. https://doi.org/10.1016/j.bioorg.2025.109040.

Article  CAS