Exploration of the mechanism by which Ubiquitin-like protein UBD promotes malignant progression of breast cancer

Siegel RL, Giaquinto AN, et al. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12–49.

PubMed  Google Scholar 

Zhang J, Huang Z, et al. PRMT1-mediated PARP1 methylation drives lung metastasis and chemoresistance via P65 activation in triple-negative breast cancer. Research. 2025;8:0854.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smolarz B, Nowak AZ, et al. Breast cancer-epidemiology, classification, pathogenesis and treatment (review of literature). Cancers (Basel). 2022. https://doi.org/10.3390/cancers14102569.

Article  PubMed  PubMed Central  Google Scholar 

Siegel RL, Miller KD, et al. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33.

PubMed  Google Scholar 

Xiong X, Zheng LW, et al. Breast cancer: pathogenesis and treatments. Signal Transduct Target Ther. 2025;10(1):49.

Article  PubMed  PubMed Central  Google Scholar 

Xia C, Dong X, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl). 2022;135(5):584–90.

Article  PubMed  PubMed Central  Google Scholar 

Lei S, Zheng R, et al. Global patterns of breast cancer incidence and mortality: a population-based cancer registry data analysis from 2000 to 2020. Cancer Commun. 2021;41(11):1183–94.

Article  Google Scholar 

Duncan W, Kerr GR. The curability of breast cancer. Br Med J. 1976;2(6039):781–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller KD, Nogueira L, et al. Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 2019;69(5):363–85.

PubMed  Google Scholar 

Fan W, Cai W, et al. Identification of seven new human MHC class I region genes around the HLA-F locus. Immunogenetics. 1996;44(2):97–103.

Article  CAS  PubMed  Google Scholar 

Aichem A, Groettrup M. The ubiquitin-like modifier FAT10 in cancer development. Int J Biochem Cell Biol. 2016;79:451–61.

Article  CAS  PubMed  Google Scholar 

Ebstein F, Lehmann A, et al. The FAT10- and ubiquitin-dependent degradation machineries exhibit common and distinct requirements for MHC class I antigen presentation. Cell Mol Life Sci. 2012;69(14):2443–54.

Article  CAS  PubMed  Google Scholar 

Mah MM, Roverato N, et al. Regulation of interferon induction by the ubiquitin-like modifier FAT10. Biomolecules. 2020. https://doi.org/10.3390/biom10060951.

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Fu L. The role of ALDH2 in tumorigenesis and tumor progression: targeting ALDH2 as a potential cancer treatment. Acta Pharm Sin B. 2021;11(6):1400–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanyi JL, George E. Personalized vaccination against ovarian cancer: what are the possibilities? Expert Rev Vaccines. 2018;17(11):955–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Theng SS, Wang W, et al. Disruption of FAT10-MAD2 binding inhibits tumor progression. Proc Natl Acad Sci U S A. 2014;111(49):E5282-5291.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merbl Y, Refour P, et al. Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell. 2013;152(5):1160–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han T, Liu Z, et al. High expression of UBD correlates with epirubicin resistance and indicates poor prognosis in triple-negative breast cancer. Onco Targets Ther. 2015;8:1643–9.

PubMed  PubMed Central  Google Scholar 

Chen X, Wu W, et al. Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance. Sci China Life Sci. 2024;67(7):1413–26.

Article  CAS  PubMed  Google Scholar 

Xue F, Zhu L, et al. FAT10 is associated with the malignancy and drug resistance of non-small-cell lung cancer. Onco Targets Ther. 2016;9:4397–409.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lukasiak S, Schiller C, et al. Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon. Oncogene. 2008;27(46):6068–74.

Article  CAS  PubMed  Google Scholar 

Liu L, Dong Z, et al. As an independent prognostic factor, FAT10 promotes hepatitis B virus-related hepatocellular carcinoma progression via Akt/GSK3β pathway. Oncogene. 2014;33(7):909–20.

Article  CAS  PubMed  Google Scholar 

Yuan R, Wang K, et al. Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying β-catenin degradation. Cancer Res. 2014;74(18):5287–300.

Article  CAS  PubMed  Google Scholar 

Akrida I, Mulita F, et al. Epithelial to mesenchymal transition (EMT) in metaplastic breast cancer and phyllodes breast tumors. Med Oncol. 2023;41(1):20.

Article  PubMed  Google Scholar 

Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pastushenko I, Brisebarre A, et al. Identification of the tumour transition States occurring during EMT. Nature. 2018;556(7702):463–8.

Article  CAS  PubMed  Google Scholar 

Nijkamp MM, Span PN, et al. Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients. Radiother Oncol. 2011;99(3):344–8.

Article  CAS  PubMed  Google Scholar 

Livasy CA, Karaca G, et al. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol. 2006;19(2):264–71.

Article  CAS  PubMed  Google Scholar 

Grigore AD, Jolly MK, et al. Tumor Budding: The Name is EMT. Partial EMT. J Clin Med. 2016. https://doi.org/10.3390/jcm5050051.

Article  PubMed  PubMed Central  Google Scholar 

Dmello C, Sawant S, et al. Vimentin regulates differentiation switch via modulation of keratin 14 levels and their expression together correlates with poor prognosis in oral cancer patients. PLoS One. 2017;12(2):e0172559.

Article  PubMed  PubMed Central  Google Scholar 

Zacharias M, Brcic L, et al. Bulk tumour cell migration in lung carcinomas might be more common than epithelial-mesenchymal transition and be differently regulated. BMC Cancer. 2018;18(1):717.

Article  PubMed  PubMed Central  Google Scholar 

George JT, Jolly MK, et al. Survival outcomes in cancer patients predicted by a partial EMT gene expression scoring metric. Cancer Res. 2017;77(22):6415–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif