Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave’s disease and control

Fish EN. The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol. 2008;8(9):737–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai R, Ahmed SA. Sexual dimorphism of miRNA expression: a new perspective in understanding the sex bias of autoimmune diseases. Ther Clin Risk Manag. 2014;10:151–63.

CAS  PubMed  PubMed Central  Google Scholar 

Cho WK. Lifelong medical challenges and immunogenetics of Turner syndrome. Clin Experimental Pediatr. 2024;67(11):560–8.

Article  Google Scholar 

Chitiashvili T, Dror I, Kim R, Hsu F-M, Chaudhari R, Pandolfi E, et al. Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation. Nat Cell Biol. 2020;22(12):1436–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wainer Katsir K, Linial M. Human genes escaping X-inactivation revealed by single cell expression data. BMC Genomics. 2019;20(1):201.

Article  PubMed  PubMed Central  Google Scholar 

Carrel L, Brown CJ. When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome. Philosophical Trans Royal Soc Lond Ser B Biol Sci. 2017;372(1733):20160355.

Article  Google Scholar 

Libert C, Dejager L, Pinheiro I. The X chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol. 2010;10(8):594–604.

Article  CAS  PubMed  Google Scholar 

Whitacre CC. Sex differences in autoimmune disease. Nat Immunol. 2001;2(9):777–80.

Article  CAS  PubMed  Google Scholar 

Klein SL, Morgan R. The impact of sex and gender on immunotherapy outcomes. Biology sex Differences. 2020;11(1):24.

Article  Google Scholar 

Arakaki R, Ishimaru N, Hayashi Y. Immunotherapeutic targets in estrogen deficiency-dependent Sjögren’s syndrome-related manifestations. Immunotherapy. 2010;2(3):339–46.

Article  CAS  PubMed  Google Scholar 

Fan H, Zhao G, Ren D, Liu F, Dong G, Hou Y. Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosus. Immunol Lett. 2017;181:71–8.

Article  CAS  PubMed  Google Scholar 

Trentin F, Signorini V, Manca ML, Cascarano G, Gualtieri L, Schilirò D, et al. Gender differences in SLE: report from a cohort of 417 caucasian patients. Lupus Sci Med. 2023;10(1):e000880.

Mateen S, Saeed H, Moin S, Khan AQ, Owais M. T helper cell subpopulations repertoire in peripheral blood and its correlation with sex of newly diagnosed arthritis patients: a gender based study. Int Immunopharmacol. 2019;74:105675.

Article  CAS  PubMed  Google Scholar 

Tomassini V, Pozzilli C. Sex hormones: a role in the control of multiple sclerosis? Expert Opin Pharmacother. 2006;7(7):857–68.

Article  CAS  PubMed  Google Scholar 

Spolarics Z. The X-files of inflammation: cellular mosaicism of X-linked polymorphic genes and the female advantage in the host response to injury and infection. Shock (Augusta Ga). 2007;27(6):597–604.

Article  CAS  PubMed  Google Scholar 

Yin X, Latif R, Tomer Y, Davies TF. Thyroid epigenetics: X chromosome inactivation in patients with autoimmune thyroid disease. Ann N Y Acad Sci. 2007;1110:193–200.

Article  CAS  PubMed  Google Scholar 

Chabchoub G, Uz E, Maalej A, Mustafa CA, Rebai A, Mnif M, et al. Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases. Arthritis Res Ther. 2009;11(4):R106.

Article  PubMed  PubMed Central  Google Scholar 

Ishido N, Inoue N, Watanabe M, Hidaka Y, Iwatani Y. The relationship between skewed X chromosome inactivation and the prognosis of Graves’ and Hashimoto’s diseases. Thyroid: Official J Am Thyroid Association. 2015;25(2):256–61.

Article  CAS  Google Scholar 

Zheng GXY, Terry JM, Belgrader P, Ryvkin P, Bent ZW, Wilson R, et al. Massively parallel digital transcriptional profiling of single cells. Nat Commun. 2017;8:14049.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu MPN, Bousounis H, Spurr P, Alomran L, Ibeawuchi N. Estimating the allele-specific expression of SNVs from 10× Genomics single-cell RNA-Sequencing data. Genes (Basel). 2020;11(3):240.

Article  PubMed  Google Scholar 

Tukiainen T, Villani A-C, Yen A, Rivas MA, Marshall JL, Satija R, et al. Landscape of X chromosome inactivation across human tissues. Nature. 2017;550(7675):244–8.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Liu H, Liu Y, Wang X, Yu S, Huang H, et al. Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq. iScience. 2023;26(9):107588.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hyun YS, Lee YH, Jo HA, Baek IC, Kim SM, Sohn HJ, et al. Comprehensive analysis of CD4(+) T cell response cross-reactive to SARS-CoV-2 antigens at the single allele level of HLA Class II. Front Immunol. 2021;12:774491.

Article  CAS  PubMed  Google Scholar 

Zhang S, Wang Y, Li H, Zhi H, Zhai X, Ruan W, et al. Tongmai Zhuke decoction restrains the inflammatory reaction of macrophages for carotid artery atherosclerosis by up-regulating lincRNA-Cox2. Biotechnol Genet Eng Rev. 2024;40(3):1758–73.

Article  CAS  PubMed  Google Scholar 

Baek IC, Choi EJ, Shin DH, Kim HJ, Choi H, Kim TG. Distributions of HLA-A, -B, and -DRB1 alleles typed by Amplicon-based next generation sequencing in Korean volunteer donors for unrelated hematopoietic stem cell transplantation. Hla. 2021;97(2):112–26.

Article  CAS  PubMed  Google Scholar 

Baek IC, Choi EJ, Kim HJ, Choi H, Kim TG. Distributions of 11-loci HLA alleles typed by Amplicon-based next-generation sequencing in south koreans. Hla. 2023;101(6):613–22.

Article  CAS  PubMed  Google Scholar 

Wu SZ, Al-Eryani G, Roden DL, Junankar S, Harvey K, Andersson A, et al. A single-cell and spatially resolved atlas of human breast cancers. Nat Genet. 2021;53(9):1334–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Yang Z, Chen W, Zhao Y, Farmer A, Tran B, et al. A multi-center cross-platform single-cell RNA sequencing reference dataset. Sci data. 2021;8(1):39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozcelik T, Uz E, Akyerli CB, Bagislar S, Mustafa CA, Gursoy A, et al. Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity. Eur J Hum Genetics: EJHG. 2006;14(6):791–7.

Article  CAS  PubMed  Google Scholar 

Brix TH, Knudsen GP, Kristiansen M, Kyvik KO, Orstavik KH, Hegedüs L. High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. J Clin Endocrinol Metab. 2005;90(11):5949–53.

Article  CAS  PubMed  Google Scholar 

Busque L, Mio R, Mattioli J, Brais E, Blais N, Lalonde Y, et al. Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. Blood. 1996;88(1):59–65.

Article  CAS  PubMed  Google Scholar 

Uz E, Mustafa C, Topaloglu R, Bilginer Y, Dursun A, Kasapcopur O, et al. Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis. Arthritis Rheum. 2009;60(11):3410–2.

Article  PubMed 

Comments (0)

No login
gif