Exploring the bidirectional association between thyrotropin and thyroid hormones in type 2 diabetes: a systematic review and meta-analysis

Bukhman G, et al. Endemic diabetes in the world’s poorest people. Lancet Diabetes Endocrinol. 2015;3(6):402–3.

Article  PubMed  Google Scholar 

Miranda JJ, et al. Understanding the rise of cardiometabolic diseases in low-and middle-income countries. Nat Med. 2019;25(11):1667–79.

Article  CAS  PubMed  Google Scholar 

Diab N, et al. Prevalence and risk factors of thyroid dysfunction in older adults in the community. Sci Rep. 2019;9(1):13156.

Article  PubMed  PubMed Central  Google Scholar 

Liu J, et al. Trends in the incidence of diabetes mellitus: results from the Global Burden of Disease Study 2017 and implications for diabetes mellitus prevention. BMC Public Health. 2020;20:1–12.

Article  Google Scholar 

Magliano DJ, Boyko EJ. IDF diabetes atlas. 2022.

Mahajan A et al. Risk Factors of Type 2 Diabetes in Population of Jammu and Kashmir, India. J Biomed Res. 2013.

Roberts RO et al. Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions. Diabetes Care. 2010.

Vanderpump MP. The epidemiology of thyroid disease. British Med Bulletin. 2011;99(1):39.

Article  Google Scholar 

Jv P. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol (Oxf). 1991;34:77–83.

Article  Google Scholar 

Taylor PN, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301–16.

Article  PubMed  Google Scholar 

Garmendia Madariaga A, et al. The Incidence and Prevalence of Thyroid Dysfunction in Europe: A Meta-Analysis. J Clin Endocrinol Metab. 2014;99(3):923–31.

Article  PubMed  Google Scholar 

JIG H. Serum TSH, T (4) and thyroid antibodies in the United States population (1988 to1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489-499

Distiller L, Polakow E, Joffe B. Type 2 diabetes mellitus and hypothyroidism: the possible influence of metformin therapy. Diabet Med. 2014;31(2):172–5.

Article  CAS  PubMed  Google Scholar 

Kalra S, Aggarwal S, Khandelwal D. Thyroid Dysfunction and Type 2 Diabetes Mellitus: Screening Strategies and Implications for Management. Diabetes Ther. 2019;10:2035.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Somwaru LL, et al. High Frequency of and Factors Associated with Thyroid Hormone Over-Replacement and Under-Replacement in Men and Women Aged 65 and Over. J Clin Endocrinol Metab. 2009;94(4):1342–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han C, et al. Subclinical Hypothyroidism and Type 2 Diabetes: A Systematic Review and Meta-Analysis. Plos One. 2015;10:e0135233.

Article  PubMed  PubMed Central  Google Scholar 

Brandt F, et al. Morbidity Before and After the Diagnosis of Hyperthyroidism: A Nationwide Register-Based Study. Plos One. 2013;8:e66711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lambadiari V, et al. Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. Endocrine. 2011;39(1):28–32.

Article  CAS  PubMed  Google Scholar 

Dueñas OHR et al. Thyroid Function and the Risk of Prediabetes and Type 2 Diabetes. J Clin Endocrinol Metabolism. 2022.

Sterne JAC, Hernan M, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomized studies of interventions. BMJ. 2016;i4919:355.

Google Scholar 

McGuinness LA, Higgins JPT. Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods. 2021;12(1):55–61.

Article  PubMed  Google Scholar 

Lehrer EJ, et al. An Introduction to Meta-Analysis. Int J Radiat Oncol Biol Phys. 2023;115(3):564–71.

Article  PubMed  Google Scholar 

Chandler J, et al. Cochrane handbook for systematic reviews of interventions. Hoboken: Wiley; 2019.

Google Scholar 

Mahmoud AA, et al. Study of Insulin Resistance in Patients with Hypothyroidism as a Risk Factor of Diabetes Mellitus. Egyptian J Hospital Med. 2022;87(1):1140–5.

Article  Google Scholar 

Han C, et al. Subclinical hypothyroidism and type 2 diabetes: a systematic review and meta-analysis. PLoS ONE. 2015;10(8):e0135233.

Article  PubMed  PubMed Central  Google Scholar 

Cettour-Rose P, et al. Hypothyroidism in rats decreases peripheral glucose utilisation, a defect partially corrected by central leptin infusion. Diabetologia. 2005;48:624–33.

Article  CAS  PubMed  Google Scholar 

Dimitriadis G, et al. The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats. Eur J Clin Invest. 1997;27(6):475–83.

Article  CAS  PubMed  Google Scholar 

Rochon C, et al. Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism. Clin Sci. 2003;104(1):7–15.

Article  CAS  Google Scholar 

Rong F, et al. Association between thyroid dysfunction and type 2 diabetes: a meta-analysis of prospective observational studies. BMC Med. 2021;19(1):257.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sjögren M, et al. Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor α1. EMBO J. 2007;26(21):4535–45.

Article  PubMed  PubMed Central  Google Scholar 

Wang C. The relationship between type 2 diabetes mellitus and related thyroid diseases. J Diabetes Res. 2013;2013:1.

Google Scholar 

Stanická S, et al. Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy. Clin Chem Lab Med (CCLM). 2005;43(7):715–20.

Article  PubMed  Google Scholar 

Iwen KA, Schröder E, Brabant G. Thyroid hormones and the metabolic syndrome. Eur Thyroid J. 2013;2(2):83–92.

Article  PubMed  PubMed Central  Google Scholar 

Dimitriadis G, et al. Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol Metab. 2006;91(12):4930–7.

Article  CAS  PubMed  Google Scholar 

Verga Falzacappa C, et al. triiodothyronine (T3) is a survival factor for pancreatic β-cells undergoing apoptosis. J Cell Physiol. 2006;206(2):309–21.

Article  PubMed  Google Scholar 

Uppal V, et al. Thyroid disorders in patients of type 2 diabetes mellitus. Indian J Clin Biochem. 2013;28(4):336–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van der Burgh AC, et al. Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study. J Clin Endocrinol Metab. 2022;10:20503121221097624.

Google Scholar 

Li Y, et al. Evaluation of the Thyroid Characteristics and Correlated Factors in Hospitalized Patients with Newly Diagnosed Type 2 Diabetes. Eur Thyroid J. 2022;15:873–84.

CAS  Google Scholar 

Birck MG, et al. Thyroid-Stimulating Hormone and Thyroid Hormones and Incidence of Diabetes: Prospective Results of the Brazilian Longitudinal Study of Adult Health (ELSA-BRASIL). Thyroid. 2022;32(6):694–704.

Article  CAS  PubMed  Google Scholar 

Sah NK, et al. Thyroid autoimmunity among type 2 diabetes mellitus: assessing anti-thyroid peroxidase (anti-TPO) antibodies. Biomedicine (India). 2021;41(4):720–3.

Google Scholar 

Khassawneh AH, et al. Prevalence and predictors of thyroid dysfunction among type 2 diabetic patients: A case–control study. Int J Gen Med. 2020;13:803–16.

Article  PubMed  PubMed Central  Google Scholar 

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