Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women

Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–84.

Article  PubMed  Google Scholar 

Joham AE, Norman RJ, Stener-Victorin E, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668–80.

Article  CAS  PubMed  Google Scholar 

Bannigida DM, Nayak BS, Vijayaraghavan R. Insulin resistance and oxidative marker in women with PCOS. Arch Physiol Biochem. 2020;126(2):183–6.

Article  CAS  PubMed  Google Scholar 

Palomba S, Daolio J, La Sala GB. Oocyte competence in women with polycystic ovary syndrome. Trends Endocrinol Metab. 2017;28(3):186–98.

Article  CAS  PubMed  Google Scholar 

Marquard KL, Stephens SM, Jungheim ES, et al. Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2011;95(6):2146–e21491.

Article  PubMed  Google Scholar 

Cano F, García-Velasco JA, Millet A, Remohí J, Simón C, Pellicer A. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J Assist Reprod Genet. 1997;14(5):254–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity’s impact. Fertil Steril. 2017;107(4):840–7.

Article  PubMed  Google Scholar 

Dobbie LJ, Pittam B, Zhao SS, et al. Childhood, adolescent, and adulthood adiposity are associated with risk of PCOS: a Mendelian randomization study with meta-analysis. Hum Reprod. 2023;38(6):1168–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu T, Goodarzi MO. Causes and consequences of polycystic ovary syndrome: insights from Mendelian randomization. J Clin Endocrinol Metab. 2022;107(3):e899–911.

Article  PubMed  Google Scholar 

Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017;356:j1.

Article  PubMed  PubMed Central  Google Scholar 

Nayudu PL, Lopata A, Jones GM, et al. An analysis of human oocytes and follicles from stimulated cycles: oocyte morphology and associated follicular fluid characteristics. Hum Reprod. 1989;4(5):558–67.

Article  CAS  PubMed  Google Scholar 

Rodgers RJ, Irving-Rodgers HF. Formation of the ovarian follicular antrum and follicular fluid. Biol Reprod. 2010;82(6):1021–9.

Article  CAS  PubMed  Google Scholar 

Dumesic DA, Meldrum DR, Katz-Jaffe MG, Krisher RL, Schoolcraft WB. Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril. 2015;103(2):303–16.

Article  PubMed  Google Scholar 

Zein Abdin Z, Geng AZ, Chandy M. Exosomes and lipid metabolism in metabolic and cardiovascular disorders. Curr Opin Lipidol. 2023;34(2):82–91.

Article  PubMed  Google Scholar 

Wortzel I, Dror S, Kenific CM, Lyden D. Exosome-Mediated metastasis: communication from a distance. Dev Cell. 2019;49(3):347–60.

Article  CAS  PubMed  Google Scholar 

Dinh PC, Paudel D, Brochu H, et al. Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nat Commun. 2020;11(1):1064.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Machtinger R, Laurent LC, Baccarelli AA. Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation. Hum Reprod Update. 2016;22(2):182–93.

CAS  PubMed  Google Scholar 

Wyse BA, Salehi R, Russell SJ, et al. Obesity and PCOS radically alters the SnRNA composition of follicular fluid extracellular vesicles. Front Endocrinol (Lausanne). 2023;14:1205385.

Article  PubMed  Google Scholar 

Yu L, Liu M, Wang Z, et al. Correlation between steroid levels in follicular fluid and hormone synthesis related substances in its exosomes and embryo quality in patients with polycystic ovary syndrome. Reprod Biol Endocrinol. 2021;19(1):74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Pan S, Li Y, Wu X. Exosomal miR-143-3p derived from follicular fluid promotes granulosa cell apoptosis by targeting BMPR1A in polycystic ovary syndrome. Sci Rep. 2022;12(1):4359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez RM, Baccarelli AA, Liang L, et al. Body mass index in relation to extracellular vesicle-linked MicroRNAs in human follicular fluid. Fertil Steril. 2019;112(2):387–e3963.

Article  PubMed  PubMed Central  Google Scholar 

Rotterdam ESHRE, ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41–7.

Article  Google Scholar 

WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.

Article  Google Scholar 

Jia X, Zhai T, Zhang JA. Circulating exosome involves in the pathogenesis of autoimmune thyroid diseases through Immunomodulatory proteins. Front Immunol. 2021;12:730089.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DiStefano JK, Piras IS, Wu X, et al. Changes in proteomic cargo of Circulating extracellular vesicles in response to lifestyle intervention in adolescents with hepatic steatosis. Clin Nutr ESPEN. 2024;60:333–42.

Article  PubMed  PubMed Central  Google Scholar 

Li H, Huang X, Chang X, et al. S100-A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF-κB pathway in polycystic ovary syndrome. J Cell Mol Med. 2020;24(1):114–25.

Article  PubMed  Google Scholar 

Magli MC, Van den Abbeel E, Lundin K, et al. Revised guidelines for good practice in IVF laboratories. Hum Reprod. 2008;23(6):1253–62.

Article  PubMed  Google Scholar 

ESHRE Capri Workshop Group. Intracytoplasmic sperm injection (ICSI) in 2006: evidence and evolution. Hum Reprod Update. 2007;13(6):515–26.

Article  Google Scholar 

Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26(6):1270–83.

Article  Google Scholar 

Jones P, Binns D, Chang HY, et al. InterProScan 5: genome-scale protein function classification. Bioinformatics. 2014;30(9):1236–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–13.

Article  CAS  PubMed  Google Scholar 

Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504.

Article  CAS 

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