Farinella F, Merone M, Bacco L, Capirchio A, Ciccozzi M, Caligiore D. Machine learning analysis of high-grade serous ovarian cancer proteomic dataset reveals novel candidate biomarkers. Sci Rep. 2022;12(1):3041.
Article CAS PubMed PubMed Central Google Scholar
Majidi A, Na R, Jordan SJ, DeFazio A, Obermair A, Friedlander M, et al. Common analgesics and ovarian cancer survival: the ovarian cancer prognosis and lifestyle (OPAL) study. J Natl Cancer Inst. 2023;115(5):570–7.
Article PubMed PubMed Central Google Scholar
Yang L, Xie HJ, Li YY, Wang X, Liu XX, Mai J. Molecular mechanisms of platinum–based chemotherapy resistance in ovarian cancer (Review). Oncol Rep. 2022;47(4):82.
Article CAS PubMed PubMed Central Google Scholar
Yang C, Xia BR, Zhang ZC, Zhang YJ, Lou G, Jin WL. Immunotherapy for ovarian cancer: adjuvant, combination, and neoadjuvant. Front Immunol. 2020;11:577869.
Article CAS PubMed PubMed Central Google Scholar
Zheng Z, Liu H, Xu Q, Cui W, Liu K. Comprehensive identification of a migrasomes-associated long non-coding RNA signature to predict the prognosis and treatment options in colon adenocarcinoma. Discov Oncol. 2025;16(1):409.
Article CAS PubMed PubMed Central Google Scholar
Cai J, Ji Z, Wu J, Chen L, Zheng D, Chen Y, et al. Development and validation of a novel Endoplasmic reticulum stress-related LncRNA prognostic signature and candidate drugs in breast cancer. Front Genet. 2022;13:949314.
Article CAS PubMed PubMed Central Google Scholar
Wu W, Zhang S, He J. The mechanism of long Non-coding RNA in Cancer radioresistance/radiosensitivity: A systematic review. Front Pharmacol. 2022;13:879704.
Article CAS PubMed PubMed Central Google Scholar
Alghazali T, Ahmed AT, Hussein UA, Sanghvi G, Uthirapathy S, Edan RT, et al. Noncoding RNA (ncRNA)-mediated regulation of TLRs: critical regulator of inflammation in tumor microenvironment. Med Oncol. 2025;42(5):144.
Liu P, Gao X, Yu Z, Liu Y, Liu Y, Lin J, et al. H19 promotes polarization and alternative splicing in tumor-associated macrophages, facilitating pancreatic cancer progression. Cancer Lett. 2024;611:217389.
Liu W, Ma J, Cheng Y, Zhang H, Luo W, Zhang H. HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells. Breast Cancer (Dove Med Press). 2016;8:223–9.
Bao X, Peng Y, Shen J, Yang L. Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis. Bioengineered. 2021;12(1):7893–906.
Article CAS PubMed PubMed Central Google Scholar
Cai Y, Sheng Z, Chen Y, Wang J. LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis. Aging. 2019;11(10):3041–54.
Article CAS PubMed PubMed Central Google Scholar
Wang X, Zhou Y, Dong K, Zhang H, Gong J, Wang S. Exosomal LncRNA HMMR-AS1 mediates macrophage polarization through miR-147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma. Environ Toxicol. 2022;37(6):1357–72.
Article CAS PubMed Google Scholar
Song Q, Xue L, Ren J, Liu X, Li G, Liu C, et al. Clinical significance of microRNA-328-3p and bone metabolism biomarkers in gout patients with different musculoskeletal ultrasonography imaging. J Orthop Surg Res. 2025;20(1):329.
Article PubMed PubMed Central Google Scholar
Wang Y, Huang D, Li M, Yang M. MicroRNA-99 family in cancer: molecular mechanisms for clinical applications. PeerJ. 2025;13:19188.
Solaimani M, Hosseinzadeh S, Abasi M. Non-coding RNAs, a double-edged sword in breast cancer prognosis. Cancer Cell Int. 2025;25(1):123.
Article CAS PubMed PubMed Central Google Scholar
Hossam Abdelmonem B, Kamal LT, Wardy LW, Ragheb M, Hanna MM, Elsharkawy M, et al. Non-coding RNAs: emerging biomarkers and therapeutic targets in cancer and inflammatory diseases. Front Oncol. 2025;15:1534862.
Article PubMed PubMed Central Google Scholar
Li D, Wang L, Feng J, Shen YW, Liu LN, Wang Y. RP11-284F21.9 promotes lung carcinoma proliferation and invasion via the regulation of miR–627–3p/CCAR1. Oncol Rep. 2020;44(4):1638–48.
CAS PubMed PubMed Central Google Scholar
Liu H, Li J, Zhao H, Liu X, Ye X. DNAJC2 is reversely regulated by miR–627–3p, promoting the proliferation of colorectal cancer. Mol Med Rep. 2021;24(2):589.
Article CAS PubMed PubMed Central Google Scholar
Meng L, Zheng Y, Liu S, Ju Y, Ren S, Sang Y, et al. ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β. Cancer Lett. 2021;519:117–29.
Article CAS PubMed Google Scholar
Wang Z, Cao Z, Wang Z. Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma. Bioengineered. 2021;12(2):11342–50.
Article CAS PubMed PubMed Central Google Scholar
Sorrelle N, Dominguez ATA, Brekken RA. From top to bottom: midkine and Pleiotrophin as emerging players in immune regulation. J Leukoc Biol. 2017;102(2):277–86.
Article CAS PubMed PubMed Central Google Scholar
Wang P, Mao YM, Zhao CN, Wang JB, Li XM, Ye DQ, et al. Association of midkine and Pleiotrophin gene polymorphisms with systemic lupus erythematosus susceptibility in Chinese Han population. Front Immunol. 2020;11:110.
Article CAS PubMed PubMed Central Google Scholar
Li YS, Hoffman RM, Le Beau MM, Espinosa R 3rd, Jenkins NA, Gilbert DJ, et al. Characterization of the human Pleiotrophin gene. Promoter region and chromosomal localization. J Biol Chem. 1992;267(36):26011–6.
Article CAS PubMed Google Scholar
Tian Z, Du Z, Bai G, Gong Q, You Y, Xu G, et al. Schwann cell derived Pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma. Cancer Gene Ther. 2024;31(4):627–40.
Article CAS PubMed Google Scholar
Sevillano J, Sánchez-Alonso MG, Zapatería B, Calderón M, Alcalá M, Limones M, et al. Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice. Diabetologia. 2019;62(1):123–35.
Article CAS PubMed Google Scholar
Zhang M, Zhou K, Wang Z, Liu T, Stevens LE, Lynce F, et al. A subpopulation of luminal progenitors secretes Pleiotrophin to promote angiogenesis and metastasis in inflammatory breast Cancer. Cancer Res. 2024;84(11):1781–98.
Article CAS PubMed PubMed Central Google Scholar
Bai PS, Xia N, Sun H, Kong Y. Pleiotrophin, a target of miR-384, promotes proliferation, metastasis and lipogenesis in HBV-related hepatocellular carcinoma. J Cell Mol Med. 2017;21(11):3023–43.
Article CAS PubMed PubMed Central Google Scholar
Zhang L, Liu X, Liu J, Zhou Z, Song Y, Cao B, et al. miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression. PLoS ONE. 2017;12(7):0179783.
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