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Integrated multi-omics analysis identifies TLR4-mediated mechanisms in ATBC-induced ovarian dysfunction and female infertility: A network toxicology, transcriptomic, and Mendelian randomization study
Integrated multi-omics analysis identifies TLR4-mediated mechanisms in ATBC-induced ovarian dysfunction and female infertility: A network toxicology, transcriptomic, and Mendelian randomization study
Acetyl tributyl citrate (ATBC), a widely used plasticizer, has raised concerns regarding its reproductive toxicity. Howeve...
The lncrna HMMR-AS1 promotes the malignant progression of ovarian cancer cells by regulating the miR-627-3p/PTN axis
The lncrna HMMR-AS1 promotes the malignant progression of ovarian cancer cells by regulating the miR-627-3p/PTN axis
LncRNAs are crucial regulators of ovarian cancer, playing a significant role in malignant transformation and closely linke...
Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women
Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction, hyperandrogenism, ...
Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL.
Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL.
Our research aimed to study the effect and mechanism of tryptase on ovarian fibrosis. The POI mouse model was established ...
Accurate prediction of benign and malignant adnexal tumors in surgical resection and conservative treatment: construction and external validation of a diagnostic model based on CEUS, HE4, and O-RADS US v2022 evaluation
Accurate prediction of benign and malignant adnexal tumors in surgical resection and conservative treatment: construction and external validation of a diagnostic model based on CEUS, HE4, and O-RADS US v2022 evaluation
To establish a diagnostic model combining contrast-enhanced ultrasound (CEUS), human epididymis protein 4 (HE4), and Ovari...
In-vitro generation of follicle-like structures from human germ cell-like cells derived from theca stem cell combined with ovarian somatic cells
In-vitro generation of follicle-like structures from human germ cell-like cells derived from theca stem cell combined with ovarian somatic cells
The objective of this study was to induce the differentiation of human theca stem cells (hTSCs) into germ cell-like cells ...
Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a
Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a
Investigating the utility of serum exosomal markers CA125, HE4, and C5a, both individually and in combination, for disting...
Identification and validation of senescence-related genes in polycystic ovary syndrome
Identification and validation of senescence-related genes in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is an exceedingly intractable issue affecting female endocrine and reproductive health. H...
No evidence for a diminished ovarian reserve among patients with hypertensive disorders of pregnancy: a case control study
No evidence for a diminished ovarian reserve among patients with hypertensive disorders of pregnancy: a case control study
Existing evidence suggests a relation between cardiovascular dysfunction and diminished ovarian reserve. While it is known...
Association between maternal polycystic ovarian syndrome undergoing assisted reproductive technology and pregnancy complications and neonatal outcomes: a systematic review and meta-analysis
Association between maternal polycystic ovarian syndrome undergoing assisted reproductive technology and pregnancy complications and neonatal outcomes: a systematic review and meta-analysis
Polycystic ovarian syndrome (PCOS) is recognized as the most prevalent endocrine disorder among women of reproductive age....
The pregnancy and oncology outcome of fertility-sparing management for synchronous primary neoplasm of endometrium and ovary
The pregnancy and oncology outcome of fertility-sparing management for synchronous primary neoplasm of endometrium and ovary
To investigate the efficacy of fertility-preserving treatment for young women with synchronous primary neoplasm of endomet...
Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period
Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period
The ovary is an important reproductive organ in mammals, and its development directly affects the sexual maturity and repr...
Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma
Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma
The epithelial-mesenchymal transition (EMT) promotes cell signaling and morphology alterations, contributing to cancer pro...
Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
Chromobox protein homolog 7 (CBX7), a member of the Polycomb repressor complex, is a potent epigenetic regulator and gene ...
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy
Clinical trials are currently exploring combinations of PARP inhibitors and immunotherapies for the treatment of ovarian c...
The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
The prolactin receptor gene (PRLR) may contribute to polycystic ovarian syndrome (PCOS) since it plays important roles in ...
Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis
Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis
Existing studies have investigated the relationship between the levels of serum inhibin B (INHB), anti-müllerian horm...
Progress of the application clinical prediction model in polycystic ovary syndrome
Progress of the application clinical prediction model in polycystic ovary syndrome
Clinical prediction models play an important role in the field of medicine. These can help predict the probability of an i...
Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos
Novel variants in TUBB8 gene cause multiple phenotypic abnormalities in human oocytes and early embryos
The genotype-phenotype relationships between TUBB8 variants and female infertility are difficult to clearly define due to ...
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis
Inflammation and immunity are two main characteristics of tumor microenvironment (TME). Interferon-gamma (IFN-γ) is g...
The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial
The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial
Women with polycystic ovary syndrome (PCOS) have higher intestinal mucosal permeability, leading to the lipopolysaccharide...
The long non-coding RNA NEAT1 promotes the progression of human ovarian cancer through targeting miR-214-3p and regulating angiogenesis
The long non-coding RNA NEAT1 promotes the progression of human ovarian cancer through targeting miR-214-3p and regulating angiogenesis
Angiogenesis and metastasis contributes substantially to the poor outcome of patients with ovarian cancer. We aimed to exp...
Correction: Effects and mechanisms of mUCMSCs on ovarian structure and function in naturally ageing C57 mice
Correction: Effects and mechanisms of mUCMSCs on ovarian structure and function in naturally ageing C57 mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Prerequisites to improve surgical cytoreduction in FIGO stage III/IV epithelial ovarian cancer and subsequent clinical ramifications
Prerequisites to improve surgical cytoreduction in FIGO stage III/IV epithelial ovarian cancer and subsequent clinical ramifications
No residual disease (CC 0) following cytoreductive surgery is pivotal for the prognosis of women with advanced stage epith...
Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis
Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by ovarian cysts, high androgen levels, and irregu...
Investigation of androgen receptor CAG repeats length in polycystic ovary syndrome diagnosed using the new international evidence-based guideline
Investigation of androgen receptor CAG repeats length in polycystic ovary syndrome diagnosed using the new international evidence-based guideline
To study whether CAG repeat polymorphism of androgen receptor (AR) contributes to the risk of polycystic ovarian morpholog...
Baicalein improves the chemoresistance of ovarian cancer through regulation of CirSLC7A6
Baicalein improves the chemoresistance of ovarian cancer through regulation of CirSLC7A6
The present study aimed to investigate whether baicalein improves the sensitivity of resistant ovarian cancer cells to cis...
Three-dimensional architecture of granulosa cell derived from oocyte cumulus complex, revealed by FIB-SEM
Three-dimensional architecture of granulosa cell derived from oocyte cumulus complex, revealed by FIB-SEM
The oocyte cumulus complex is mainly composed of an oocyte, the perivitelline space, zona pellucida and numerous granulosa...
Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization
Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization
Follicular microenvironment has been proposed as an important factor for oocyte grown and maturation. We sought to evaluat...
Potential factors result in diminished ovarian reserve: a comprehensive review
Potential factors result in diminished ovarian reserve: a comprehensive review
The ovarian reserve is defined as the quantity of oocytes stored in the ovary or the number of oocytes that can be recruit...
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