A perspective on patient-derived orthotopic xenograft (PDOX) mouse models for identification of novel and individualized treatment for sarcoma

Al Shihabi A, Tebon PJ, Nguyen HTL et al (2024) The landscape of drug sensitivity and resistance in sarcoma. Cell Stem Cell 31(10):1524-1542.e1524. https://doi.org/10.1016/j.stem.2024.08.010

Article  CAS  PubMed  Google Scholar 

Gamboa AC, Gronchi A, Cardona K (2020) Soft-tissue sarcoma in adults: an update on the current state of histiotype-specific management in an era of personalized medicine. CA Cancer J Clin 70(3):200–229. https://doi.org/10.3322/caac.21605

Article  PubMed  Google Scholar 

Ryan CW, Merimsky O, Agulnik M et al (2016) PICASSO III: a phase III, placebo-controlled study of doxorubicin with or without palifosfamide in patients with metastatic soft tissue sarcoma. J Clin Oncol 34(32):3898–3905. https://doi.org/10.1200/jco.2016.67.6684

Article  CAS  PubMed  Google Scholar 

Kirthiga Devi SS, Singh S, Joga R et al (2024) Enhancing cancer immunotherapy: exploring strategies to target the PD-1/PD-L1 axis and analyzing the associated patent, regulatory, and clinical trial landscape. Eur J Pharm Biopharm 200:114323. https://doi.org/10.1016/j.ejpb.2024.114323

Article  CAS  PubMed  Google Scholar 

Liu B, Zhou H, Tan L et al (2024) Exploring treatment options in cancer: tumor treatment strategies. Signal Transduct Target Ther 9(1):175. https://doi.org/10.1038/s41392-024-01856-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grünewald TG, Alonso M, Avnet S et al (2020) Sarcoma treatment in the era of molecular medicine. EMBO Mol Med 12(11):e11131. https://doi.org/10.15252/emmm.201911131

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho D, Quake SR, McCabe ERB et al (2020) Enabling technologies for personalized and precision medicine. Trends Biotechnol 38(5):497–518. https://doi.org/10.1016/j.tibtech.2019.12.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atlı Şekeroğlu Z, Şekeroğlu V (2024) A review on patient-derived 3D micro cancer approach for drug screen in personalized cancer medicine. Curr Cancer Drug Targets. https://doi.org/10.2174/0115680096285910240206044830

Article  Google Scholar 

Trivedi S, Tilsed C, Liousia M et al (2024) Transcriptomic analysis-guided assessment of precision-cut tumor slices (PCTS) as an ex-vivo tool in cancer research. Sci Rep 14(1):11006. https://doi.org/10.1038/s41598-024-61684-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma K, Dey S, Karmakar R et al (2024) A comprehensive review of 3D cancer models for drug screening and translational research. Cancer Innov 3(1):e102. https://doi.org/10.1002/cai2.102

Article  CAS  PubMed  Google Scholar 

Ireson CR, Alavijeh MS, Palmer AM et al (2019) The role of mouse tumour models in the discovery and development of anticancer drugs. Br J Cancer 121(2):101–108. https://doi.org/10.1038/s41416-019-0495-5

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Wu W, Cai C et al (2023) Patient-derived xenograft models in cancer therapy: technologies and applications. Signal Transduct Target Ther 8(1):160. https://doi.org/10.1038/s41392-023-01419-2

Article  PubMed  PubMed Central  Google Scholar 

Higuchi T, Igarashi K, Yamamoto N et al (2021) Osteosarcoma patient-derived orthotopic xenograft (PDOX) models used to identify novel and effective therapeutics: a review. Anticancer Res 41(12):5865–5871. https://doi.org/10.21873/anticanres.15406

Article  CAS  PubMed  Google Scholar 

Higuchi T, Igarashi K, Yamamoto N et al (2022) Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: a strategy for clinical application. Front Oncol 12:957844. https://doi.org/10.3389/fonc.2022.957844

Article  CAS  PubMed  PubMed Central  Google Scholar 

Higuchi T, Yamamoto N, Hayashi K et al (2023) High clinical concordance of drug resistance in patient-derived orthotopic xenograft (PDOX) mouse models: first step to validated precise individualized cancer chemotherapy. Anticancer Res 43(10):4277–4284. https://doi.org/10.21873/anticanres.16622

Article  CAS  PubMed  Google Scholar 

Hoffman RM (2017) Patient-derived orthotopic xenograft (PDOX) models of melanoma. Int J Mol Sci. https://doi.org/10.3390/ijms18091875

Article  PubMed  PubMed Central  Google Scholar 

Igarashi K, Kawaguchi K, Murakami T et al (2020) Patient-derived orthotopic xenograft models of sarcoma. Cancer Lett 469:332–339. https://doi.org/10.1016/j.canlet.2019.10.028

Article  CAS  PubMed  Google Scholar 

Furukawa T, Fu X, Kubota T et al (1993) Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue. Cancer Res 53(5):1204–1208

CAS  PubMed  Google Scholar 

Furukawa T, Kubota T, Watanabe M et al (1993) Orthotopic transplantation of histologically intact clinical specimens of stomach cancer to nude mice: correlation of metastatic sites in mouse and individual patient donors. Int J Cancer 53(4):608–612. https://doi.org/10.1002/ijc.2910530414

Article  CAS  PubMed  Google Scholar 

Hiroshima Y, Maawy A, Zhang Y et al (2014) Metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model is inhibited by neoadjuvant chemotherapy in combination with fluorescence-guided surgery with an anti-CA 19–9-conjugated fluorophore. PLoS ONE 9(12):e114310. https://doi.org/10.1371/journal.pone.0114310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiroshima Y, Maawy A, Zhang Y et al (2016) Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy. Oncotarget 7(44):71696–71702. https://doi.org/10.18632/oncotarget.12322

Article  PubMed  PubMed Central  Google Scholar 

Hiroshima Y, Zhang Y, Zhang N et al (2015) Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern. PLoS ONE 10(2):e0117417. https://doi.org/10.1371/journal.pone.0117417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoffman RM (2015) Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts. Nat Rev Cancer 15(8):451–452. https://doi.org/10.1038/nrc3972

Article  CAS  PubMed  Google Scholar 

Togo S, Wang X, Shimada H et al (1995) Cancer seed and soil can be highly selective: human-patient colon tumor lung metastasis grows in nude mouse lung but not colon or subcutis. Anticancer Res 15(3):795–798

CAS  PubMed  Google Scholar 

Nomura T, Kurebayashi J, Moriya T et al (2021) A case of rare matrix-producing triple-negative breast carcinoma for which drug response in a patient-derived orthotopic xenograft mouse model was correlated with patient response. Anticancer Res 41(12):6191–6197. https://doi.org/10.21873/anticanres.15438

Article  CAS  PubMed  Google Scholar 

Turner MA, Hollandsworth HM, Amirfakhri S et al (2022) Anti-mucin 4 fluorescent antibody brightly targets colon cancer in patient-derived orthotopic xenograft mouse models: a proof-of-concept study for future clinical applications. Am J Surg 224(4):1081–1085. https://doi.org/10.1016/j.amjsurg.2022.05.036

Article  PubMed  PubMed Central  Google Scholar 

Sugisawa N, Higuchi T, Han Q et al (2021) Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. Cancer Chemother Pharmacol 88(1):61–67. https://doi.org/10.1007/s00280-021-04261-x

Article  CAS  PubMed  Google Scholar 

Sugisawa N, Miyake K, Higuchi T et al (2022) High Incidence of lymph-node metastasis in a pancreatic-cancer patient-derived orthotopic xenograft (PDOX) NOG-mouse model. Anti

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