World Health Organization. Noncommunicable diseases country profiles 2018. World Health Organization; 2018.
Lobstein T, Brinsden H, Neveux M. World Obesity Atlas 2022. World Obesity Federation; 2022.
Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet. 1997;27:325–51.
Elks CE, den Hoed M, Zhao JH, Sharp SJ, Wareham NJ, Loos RJF, et al. Variability in the heritability of body mass index: a systematic review and meta-regression. Front Endocrinol. 2012;3:29.
Ordovas JM, Shen J. Gene–environment interactions and susceptibility to metabolic syndrome and other chronic diseases. J Periodontol. 2008;79:1508–13. 8 Suppl.
CAS PubMed PubMed Central Google Scholar
Ramos-Lopez O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, et al. Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. J Nutrigenet Nutrigenom. 2017;10:43–62.
Bordoni L, Gabbianelli R. Primers on nutrigenetics and nutri(epi)genomics: Origins and development of precision nutrition. Biochimie. 2019;160:156–71.
Weinhold B. Epigenetics: the science of change. Environ Health Perspect. 2006;114:A160–7.
PubMed PubMed Central Google Scholar
Friso S, Udali S, De Santis D, Choi S-W. One-carbon metabolism and epigenetics. Mol Aspects Med. 2017;54:28–36.
Mahmoud AM. An overview of epigenetics in obesity: the role of lifestyle and therapeutic interventions. Int J Mol Sci. 2022;23:1341.
CAS PubMed PubMed Central Google Scholar
Jiao F, Yan X, Yu Y, Zhu X, Ma Y, Yue Z, et al. Protective effects of maternal methyl donor supplementation on adult offspring of high fat diet-fed dams. J Nutr Biochem. 2016;34:42–51.
Yadav DK, Shrestha S, Lillycrop KA, Joglekar CV, Pan H, Holbrook JD, et al. Vitamin B12 supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits. Epigenomics. 2018;10:71–90.
Saber Cherif L, Pourié G, Geoffroy A, Julien A, Helle D, Robert A, et al. Methyl donor deficiency during gestation and lactation in the rat affects the expression of neuropeptides and related receptors in the hypothalamus. Int J Mol Sci. 2019;20:5097.
PubMed PubMed Central Google Scholar
Milagro FI, Mansego ML, De Miguel C, Martínez JA. Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives. Mol Aspects Med. 2013;34:782–812.
Ramos-Lopez O, Riezu-Boj JI, Milagro FI. Genetic and epigenetic nutritional interactions influencing obesity risk and adiposity outcomes. Curr Opin Clin Nutr Metab Care. 2022;25:235–40.
Huang T, Zheng Y, Qi Q, Xu M, Ley SH, Li Y, et al. DNA methylation variants at HIF3A locus, B-vitamin intake, and long-term weight change: gene-diet interactions in two U.S. cohorts. Diabetes. 2015;64:3146–54.
CAS PubMed PubMed Central Google Scholar
Waterland R, Travisano M, Tahiliani K, Rached M, Mirza S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes. 2008;32:1373–9.
Taylor RM, Smith R, Collins CE, Mossman D, Wong-Brown MW, Chan E-C, et al. Methyl-donor and cofactor nutrient intakes in the first 2–3 years and global DNA methylation at age 4: a prospective cohort study. Nutrients. 2018;10:273.
PubMed PubMed Central Google Scholar
Dominguez-Salas P, Moore SE, Cole D, da Costa K-A, Cox SE, Dyer RA, et al. DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr. 2013;97:1217–27.
CAS PubMed PubMed Central Google Scholar
Pauwels S, Ghosh M, Duca RC, Bekaert B, Freson K, Huybrechts I, et al. Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants. Clin Epigenet. 2017;9:16.
Poursalehi D, Lotfi K, Mirzaei S, Asadi A, Akhlaghi M, Saneei P. Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents. Sci Rep. 2022;12:17045.
CAS PubMed PubMed Central Google Scholar
Gomes Domingos AL, Miranda AEDS, Pimenta AM, Hermsdorff HHM, Oliveira FLP, Dos Santos LC, et al. Cohort profile: the cohort of universities of Minas Gerais (CUME). Int J Epidemiol. 2018;47:1743–1744h.
Siqueira JH, Mill JG, Velasquez-Melendez G, Moreira AD, Barreto SM, Benseñor IM, et al. Sugar-sweetened soft drinks and fructose consumption are associated with hyperuricemia: cross-sectional analysis from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Nutrients. 2018;10:981.
PubMed PubMed Central Google Scholar
World Health Organization. Obesity: preventing and managing the global epidemic: report of a WHO consultation on obesity. In: Obesity: preventing and managing the global epidemic: report of a WHO consultation on obesity. World Health Organization; 1998.
Miranda AEDS, Ferreira AVM, Oliveira FLP, Hermsdorff HHM, Bressanira J, Pimenta AM, et al. Validação da síndrome metabólica e de seus componentes autodeclarados no estudo cume. Reme: Revista Mineira de Enfermagem. 2017;21.
Azarias HGA, Marques-Rocha JL, Miranda AEDS, Dos Santos LC, Gomes Domingos AL, Hermsdorff HHM, et al. Online food frequency questionnaire from the cohort of universities of Minas Gerais (CUME Project, Brazil): construction, validity, and reproducibility. Front Nutr. 2021;8:709915.
PubMed PubMed Central Google Scholar
IBGE. Pesquisa de orçamentos familiares 2008-2009: tabelas de composição nutricional dos alimentos consumidos no Brasil. Rio de Janeiro: IBGE. 2011. 360.
TACO. Universidade Estadual de Campinas - Núcleo de Estudos e Pesquisas em Alimentação. Tabela brasileira de composição de alimentos - TACO, versão 4. 2011.
United States Department of Agriculture. https://data.nal.usda.gov/dataset/composition-foods-raw-processed-prepared-usda-national-nutrient-database-standard-referenc-9. Accessed 7 Dec 2023.
Zeisel SH, Mar M-H, Howe JC, Holden JM. Concentrations of choline-containing compounds and betaine in common foods. J Nutr. 2003;133:1302–7.
Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr. 1997;65(4):1220S–1228S. Suppldiscussion 1229S-1231S.
Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, et al. National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health. 2015;1:40–3.
Textor J, van der Zander B, Gilthorpe MS, Liskiewicz M, Ellison GT. Robust causal inference using directed acyclic graphs: the R package “dagitty. Int J Epidemiol. 2016;45:1887–94.
Mahmoud AM, Ali MM. Methyl donor micronutrients that modify DNA methylation and cancer outcome. Nutrients. 2019;11:608.
CAS PubMed PubMed Central Google Scholar
Mazur-Bialy AI, Pocheć E. Vitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development. Life Sci. 2017;178:9–16.
Kwon Y-J, Park DH, Choi J-E, Lee D, Hong K-W, Lee J-W. Identification of the interactions between specific genetic polymorphisms and nutrient intake associated with general and abdominal obesity in middle-aged adults. Clin Nutr. 2022;41:543–51.
Ju L, Wei X, Yu D, Fang H, Cheng X, Piao W, et al. Dietary micronutrient status and relation between micronutrient intakes and overweight and obesity among non-pregnant and non-lactating women aged 18 to 49 in China. Nutrients. 2022;14:1895.
CAS PubMed PubMed Central Google Scholar
Li X, Wang T, Zhao M, Huang T, Sun D, Han L, et al. DNA methylation variant, B-vitamins intake and longitudinal change in body mass index. Int J Obes. 2019;43:468–74.
Pereira GA, Bressan J, Oliveira FLP, Sant’Ana HMP, Pimenta AM, Lopes LL, et al. Dietary folate intake is negatively associated with excess body weight in Brazilian graduates and postgraduates (CUME Project). Nutrients. 2019;11:518.
CAS PubMed PubMed Central Google Scholar
Lyon P, Strippoli V, Fang B, Cimmino L. B Vitamins and one-carbon metabolism: implications in human health and disease. Nutrients. 2020;12:2867.
CAS PubMed PubMed Central Google Scholar
Pufulete M, Al-Ghnaniem R, Rennie JA, Appleby P, Harris N, Gout S, et al. Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. Br J Cancer. 2005;92:838–42.
CAS PubMed PubMed Central Google Scholar
Crider KS, Quinlivan EP, Berry RJ, Hao L, Li Z, Maneval D, et al. Genomic DNA Methylation changes in response to folic acid supplementation in a population-based intervention study among women of reproductive age. PLoS One. 2011;6:e28144.
CAS PubMed PubMed Central Google Scholar
Kok DEG, Dhonukshe-Rutten RAM, Lute C, Heil SG, Uitterlinden AG, van der Velde N, et al. The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects. Clin Epigenetics. 2015;7:121.
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