Camino T, Lago-Baameiro N, Pardo M. Extracellular vesicles as carriers of adipokines and their role in obesity. Biomedicines. 2023;11:422.
Article CAS PubMed PubMed Central Google Scholar
Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm. 2010;2010:802078.
Article PubMed PubMed Central Google Scholar
Hall J, Juncos L, Wang Z, Hall M, Do Carmo J. Da Silva A. Obesity, hypertension, and chronic kidney disease. Int J Nephrol Renovasc Dis. 2014;7:75–88.
Article PubMed PubMed Central Google Scholar
Connolly KD, Wadey RM, Mathew D, Johnson E, Rees DA, James PE. Evidence for adipocyte-derived extracellular vesicles in the human circulation. Endocrinology. 2018;159:3259–67.
Article CAS PubMed PubMed Central Google Scholar
Ståhl A-L, Johansson K, Mossberg M, Kahn R, Karpman D. Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases. Pediatr Nephrol. 2019;34:11–30.
O’Brien K, Breyne K, Ughetto S, Laurent LC, Breakefield XO. RNA delivery by extracellular vesicles in mammalian cells and its applications. Nat Rev Mol Cell Biol. 2020;21:585–606.
Article PubMed PubMed Central Google Scholar
Huang Z, Xu A. Adipose extracellular vesicles in intercellular and inter-organ crosstalk in metabolic health and diseases. Front Immunol. 2021;12:608680.
Article CAS PubMed PubMed Central Google Scholar
Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, et al. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016;94:1241–53.
Article CAS PubMed PubMed Central Google Scholar
Pardo F, Villalobos-Labra R, Sobrevia B, Toledo F, Sobrevia L. Extracellular vesicles in obesity and diabetes mellitus. Mol Asp Med. 2018;60:81–91.
Sandoval-Bórquez A, Carrión P, Hernández MP, Pérez JA, Tapia-Castillo A, Vecchiola A, et al. Adipose tissue dysfunction and the role of adipocyte-derived extracellular vesicles in obesity and metabolic syndrome. J Endocr Soc. 2024;8:bvae126.
Article PubMed PubMed Central Google Scholar
Mei R, Qin W, Zheng Y, Wan Z, Liu L. Role of adipose tissue derived exosomes in metabolic disease. Front Endocrinol (Lausanne). 2022;13:873865.
Article PubMed PubMed Central Google Scholar
Liu HH, Li XQ, Liu JF, Cui S, Liu H, Hu B, et al. miR-6869-5p transported by plasma extracellular vesicles mediates renal tubule injury and renin-angiotensin system activation in obesity. Front Med (Lausanne). 2021;8:725598.
Article PubMed PubMed Central Google Scholar
Karpman D, Ståhl A-l, Arvidsson I. Extracellular vesicles in renal disease. Nat Rev Nephrol. 2017;13:545–62.
Article CAS PubMed Google Scholar
Imig JD, Ryan MJ. Immune and inflammatory role in renal disease. Compr Physiol. 2013;3:957–76.
Article PubMed PubMed Central Google Scholar
Kawarazaki W, Fujita T. The role of aldosterone in obesity-related hypertension. Am J Hypertens. 2016;29:415–23.
Article CAS PubMed PubMed Central Google Scholar
Fuchs A, Samovski D, Smith GI, Cifarelli V, Farabi SS, Yoshino J, et al. Associations among adipose tissue immunology, inflammation, exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease. Gastroenterology. 2021;161:968–81.e12.
Article CAS PubMed PubMed Central Google Scholar
Welsh JA, Goberdhan DCI, O’Driscoll L, Buzas EI, Blenkiron C, Bussolati B, et al. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024;13:e12404.
Article PubMed PubMed Central Google Scholar
Théry C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc in Cell Biol. 2006;30:3.22.1–3.9.
Shelke GV, Lässer C, Gho YS, Lötvall J. Importance of exosome depletion protocols to eliminate functional and RNA-containing extracellular vesicles from fetal bovine serum. J Extracell Vesicles. 2014;3:24783.
Lobos-Gonz lez L, Bustos R, Campos A, Silva V, Silva V, Jeldes E. et al. Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells. Sci Rep. 2020;10:343.
Clement E, Lazar I, Attan‚ C, Carri‚ L, Dauvillier S, Ducoux-Petit M. et al. Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells. EMBO J. 2020;39:e102525
Article CAS PubMed PubMed Central Google Scholar
Liu S, Mahairaki V, Bai H, Ding Z, Li J, Witwer KW, et al. Highly purified human extracellular vesicles produced by stem cells alleviate aging cellular phenotypes of senescent human cells. Stem Cells. 2019;37:779–90.
Article CAS PubMed PubMed Central Google Scholar
Figueroa A, Congrove NR, Sillik SA, Sadideen DT, Falk T, Bowes Rickman C, et al. Exosome uptake is selective but not species or tissue-specific. Investigat Ophthalmol Vis Sci. 2018;59:3993.
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–8.
Article CAS PubMed Google Scholar
Devarajan P. Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. Scand J Clin Lab Invest. 2008;241:89–94.
Olivieri C, Ruzza M, Tolaj F, Dadalt L, Magni P, editors. Molecular and functional characterization of human SW 872 adipocytes as a model system for testing nutraceutical products. The 2nd International Electronic Conference on Nutrients 2022 2022-03-14: MDPI.
Tarjus A, Martínez-Martínez E, Amador C, Latouche C, El Moghrabi S, Berger T, et al. Neutrophil gelatinase-associated lipocalin, a novel mineralocorticoid biotarget, mediates vascular profibrotic effects of mineralocorticoids. Hypertension. 2015;66:158–66.
Article CAS PubMed Google Scholar
Tapia-Castillo A, Carvajal CA, Campino C, Hill C, Allende F, Vecchiola A, et al. The expression of RAC1 and mineralocorticoid pathway-dependent genes are associated with different responses to salt intake. Am J Hypertens. 2015;28:722–8.
Article CAS PubMed Google Scholar
Cassidy H, Slyne J, Higgins M, Radford R, Conlon PJ, Watson AJ, et al. Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells—a novel source of urinary biomarkers of renal injury. Biochim Biophys Acta (BBA)—Mol Basis Dis. 2019;1865:165532.
Koenen M, Hill MA, Cohen P, Sowers JR. Obesity, adipose tissue and vascular dysfunction. Circul Res. 2021;128:951–68.
Jing H, Tang S, Lin S, Liao M, Chen H, Zhou J. The role of extracellular vesicles in renal fibrosis. Cell Death Dis. 2019;10:367.
Article CAS PubMed PubMed Central Google Scholar
Kosanovic M, Llorente A, Glamoclija S, Valdivielso JM, Bozic M. Extracellular vesicles and renal fibrosis: an odyssey toward a new therapeutic approach. Int J Mol Sc. 2021;22:3887
Gimbrone MA Jr, García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 2016;118:620–36.
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