Fatima MT, Ahmed I, Fakhro KA, Akil ASA. Melanocortin-4 receptor complexity in energy homeostasis,obesity and drug development strategies. Diab Obes Metab. 2022;24:583–98.
Michael JK, Bradford BL, Alastair SG. Melanocortin-4 receptor–regulated energy homeostasis. Nat Neurosci. 2016;19:206–19.
Yeo GSH, Chao DHM, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, et al. The melanocortin pathway and energy homeostasis: from discovery to obesity therapy. Mol Metab. 2021;48:101206.
Article CAS PubMed PubMed Central Google Scholar
Lu X-Y, Gregory SB, Huda A, Stanley JW. Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci. 2003;23:7863–72.
Article CAS PubMed PubMed Central Google Scholar
Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19:155–7.
Article CAS PubMed Google Scholar
Farooqi IS, Stenvert D, Agnes C, Julia MK, Joanna B, Sarah L, et al. Heterozygosity for a POMC-null mutation and increased obesity risk in humans. Diabetes. 2006;55:2549–53.
Article CAS PubMed Google Scholar
Schrander-Stumpel CT, Curfs LM, Sastrowijoto P, Cassidy SB, Schrander JJ, Fryns JP. Prader-Willi syndrome: causes of death in an international series of 27 cases. Am J Med Genet A. 2004;124A:333–8.
Stewart LE, Sophie JK, Arabella S, Elizabeth JE, Bruce JT, John T. Mortality in Prader-Willi syndrome. Am J Ment Retard. 2006;111:193–8.
Yang-Wen H, Yi-Wen T, Hsin-Hung L, Chi-Yu L, Chiu-Ya L, Guor MH. Depletion of alpha-melanocyte-stimulating hormone induces insatiable appetite and gains in energy reserves and body weight in zebrafish. Biomedicines. 2021;9:941.
Anthony M. Setmelanotide: first approval. Drugs. 2021;81:397–403.
Meier JJ, Gallwitz B, Schmidt WE, Nauck MA. Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives. Eur J Pharmacol. 2002;440:269–79.
Article CAS PubMed Google Scholar
Matthew RH. Neuronal and intracellular signaling pathways mediating GLP-1 energy balance and glycemic effects. Physiol Behav. 2012;106:413–6.
Diene G, Angulo M, Hale PM, Jepsen CH, Hofman PL, Hokken-Koelega A, et al. Liraglutide for weight management in children and adolescents with Prader-Willi syndrome and obesity. J Clin Endocrinol Metab. 2022;108:4–12.
Article PubMed PubMed Central Google Scholar
Danilo F, Graziano G, Claudia B, Sarah B, Marco C, Antonino C. Use of GLP-1 receptor agonists in Prader-Willi syndrome: report of six cases. Diab Care. 2014;37:e76–e77.
Sana A, Arooj N, Mahnoor K. Weight loss of over 100 lbs in a patient of Prader-Willi syndrome treated with glucagon-like peptide-1 (GLP-1) agonists. Cureus. 2023;15:e35102.
Ranim M, Virginia K, Merlin GB. Clinical trials in Prader-Willi syndrome: a review. Int J Mol Sci. 2023;24:2150.
Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med. 2015;373:11–22.
John PHW, Rachel LB, Salvatore C, Melanie D, Luc FVG, Ildiko L. Once-eeekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021;384:989–1002.
Ania MJ, Louis JA, Nadia NA, Sean W, Lisa C, Breno A, et al. Tirzepatide once weekly for the treatment of obesity. N Engl J Med. 2022;387:205–16.
Ania MJ, Lee MK, Juan PF, Qiwei W, Yu D, Sirel G, et al. Triple-hormone-receptor agonist retatrutide for obesity—a phase 2 trial. N Engl J Med. 2023;389:514–26.
Jonathan EC. Targeting the GIPR for obesity: to agonize or antagonize? Potential mechanisms. Mol Metab. 2021;46:101139.
Miguel A, Sánchez-Garrido, Sara JB, Christoffer C, Timo DM, Richard DD, et al. GLP-1/glucagon receptor co-agonism for treatment of obesity. Diabetologia. 2017;60:1851–61.
Haqq AM, Chung WK, Dollfus H, Haws RM, Martos-Moreno GÁ, Poitou C, et al. Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period. Lancet Diab Endocrinol. 2022;10:859–68.
Silva AA, Kuo JJ, Tallam LS, Liu J, Hall JE. Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4 receptor activation?. Hypertension. 2006;47:259–64.
Jerry RG, Jeffrey WM, Julia MK, Elana H, Julie HS, Gregory SC, et al. Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med. 2009;360:44–52.
Chen AS, Metzger JM, Trumbauer ME, Guan XM, Yu H, Frazier EG, et al. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res. 2000;9:145–54.
Article CAS PubMed Google Scholar
Alastair SG, Chia L, Joseph CM, Bhavik PS, Emily W, Jennifer SS, et al. A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015;18:863–71.
Niels V, Curtis BP, Michele MC, Hans-Rudolf B. Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons. Am J Physiol Regul Integr Comp Physiol. 2003;285:R470–R478.
Xiaosong M, Jens B, Frances MA. Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons. J Neurosci. 2007;27:7125–9.
Mitsuharu M, Hiroaki Y, Hitomi O, Kazunobu A, Tadahiro N, Sayuri N, et al. Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis. PLoS One. 2020;15:e0228212.
Stina B, Karolina PS. GLP-1 and its analogs: does sex matter?. Endocrinology. 2025;166:bqae165.
Peter S, James N, Zentner Ali, Jesse B, Nadia K. Factors associated with weight loss response to GLP-1 analogues for obesity treatment: a retrospective cohort analysis. BMJ Open. 2025;15:e089477.
Marella M, Andrea C, Giuseppina TR, Laura N, Marco S, Paolo M, et al. Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study. Pharmacol Res. 2025;ume 219:107866.
Ilaria, Gloria G, Marianna C, Chiara G, Frida L, Danila C. Sex-differences in response to treatment with liraglutide 3.0 mg. J Clin Med. 2024;13:3369.
Thomas R, Irene G, Tim K, Yuliang W, Michael S, David T. Sex differences in GLP-1 signaling across species. https://doi.org/10.1101/2025.03.17.643822.
Claudia DM, Morgane T. Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice. Psychopharmacology (Berl). 2023;240:1287–98.
Xueli Z, Yi Z, Shuobing C, Hua S. Anti-diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications. J Cachexia Sarcopenia Muscle. 2021;12:1368–79.
Jing H, Tian G, Huinan Z, Xing W. Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999-2016. Sci Rep. 2023;13:15958.
Heather JL, Nadine SC, Richard DM, Wayne WC. Higher protein intake preserves lean mass and satiety with weight loss in pre-obese and obese women. Obesity (Silver Spring). 2007;15:421–9.
Ian JN, Jennifer L, Andreas LB. Changes in lean body mass with glucagon-like peptide-1- based therapies and mitigation strategies. Diab Obes Metab. 2024;26:16–27.
Pourhassan M, Bosy-Westphal A, Schautz B, Braun W, Glüer CC, Müller MJ. Impact of body composition during weight change on resting energy expenditure and homeostasis model assessment index in overweight nonsmoking adults. Am J Clin Nutr. 2014;99:779–91.
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