Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target

BBray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

Google Scholar 

Broström O. Ulcerative colitis and colon cancer: the role of surveillance. Ann Med. 1989;21:309–11.

PubMed  Google Scholar 

Temby M, Boye TL, Hoang J, Nielsen OH, Gubatan J. Kinase signaling in colitis-associated colon cancer and inflammatory bowel disease. Biomolecules. 2023;13:1620.

CAS  PubMed  PubMed Central  Google Scholar 

Du H, Xia H, Liu T, Li Y, Liu J, Xie B, et al. Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer. iScience. 2021;24:102169.

CAS  PubMed  PubMed Central  Google Scholar 

Gubatan J, Boye TL, Temby M, Sojwal RS, Holman DR, Sinha SR, et al. Gut microbiome in inflammatory bowel disease: role in pathogenesis, dietary modulation, and colitis-associated colon cancer. Microorganisms. 2022;10:1371.

CAS  PubMed  PubMed Central  Google Scholar 

Neurath MF. IL-23 in inflammatory bowel diseases and colon cancer. Cytokine Growth Factor Rev. 2019;45:1–8.

CAS  PubMed  Google Scholar 

Klampfer L. Cytokines, inflammation and colon cancer. Curr Cancer Drug Targets. 2011;11:451–64.

CAS  PubMed  PubMed Central  Google Scholar 

Kapoor M, Chao MJ, Johnson EC, Novikova G, Lai D, Meyers JL, et al. Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases. Nat Commun. 2021;12:5071.

CAS  PubMed  PubMed Central  Google Scholar 

Liang L, Liang X, Yu X, Xiang W. Bioinformatic analyses and integrated machine learning to predict prognosis and therapeutic response based on E3 ligase-related genes in colon cancer. J Cancer. 2024;15:5376–95.

CAS  PubMed  PubMed Central  Google Scholar 

Ouyang C, Yu X, Wang H, Zeng P. Multidimensional bioinformatics perspective on smoking-linked driver genes and immune regulatory mechanisms in non-small cell lung cancer. J Transl Med. 2025;23:330.

CAS  PubMed  PubMed Central  Google Scholar 

Li H, Wang Z, Guan Z, Miao J, Li W, Yu P, et al. UCFNNet: Ulcerative colitis evaluation based on fine-grained lesion learner and noise suppression gating. Comput Methods Prog Biomed. 2024;247:108080.

Google Scholar 

Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, et al. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol. 2007;8:R131.

PubMed  PubMed Central  Google Scholar 

Olsen J, Gerds TA, Seidelin JB, Csillag C, Bjerrum JT, Troelsen JT, et al. Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data. Inflamm Bowel Dis. 2009;15:1032–8.

PubMed  Google Scholar 

Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A. Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling. PLoS One. 2013;8:e76235.

PubMed  PubMed Central  Google Scholar 

Cordero D, Solé X, Crous-Bou M, Sanz-Pamplona R, Paré-Brunet L, Guinó E, et al. Large differences in global transcriptional regulatory programs of normal and tumor colon cells. BMC Cancer. 2014;14:708.

PubMed  PubMed Central  Google Scholar 

Díez-Villanueva A, Sanz-Pamplona R, Solé X, Cordero D, Crous-Bou M, Guinó E, et al. COLONOMICS—integrative omics data of one hundred paired normal-tumoral samples from colon cancer patients. Sci Data. 2022;9:595.

PubMed  PubMed Central  Google Scholar 

Ryan BM, Zanetti KA, Robles AI, Schetter AJ, Goodman J, Hayes RB, et al. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer. Int J Cancer. 2014;134:1399–407.

CAS  PubMed  Google Scholar 

Gkatzionis A, Burgess S, Newcombe PJ. Statistical methods for cis-Mendelian randomization with two-sample summary-level data. Genet Epidemiol. 2023;47:3–25.

CAS  PubMed  Google Scholar 

Pierce BL, Ahsan H, Vanderweele TJ. Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol. 2011;40:740–52.

PubMed  Google Scholar 

Lee CH, Cook S, Lee JS, Han B. Comparison of two meta-analysis methods: inverse-variance-weighted average and weighted sum of Z-scores. Genomics Inf. 2016;14:173–80.

Google Scholar 

Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol. 2017;46:1985–98.

PubMed  PubMed Central  Google Scholar 

Uhlitz F, Bischoff P, Peidli S, Sieber A, Trinks A, Lüthen M, et al. Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer. EMBO Mol Med. 2021;13:e14123.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Yu X, Zheng L, Zhang Y, Li Y, Fang Q, et al. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature. 2018;564:268–72.

CAS  PubMed  Google Scholar 

Zhang Y, Zheng L, Zhang L, Hu X, Ren X, Zhang Z. Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients. Sci Data. 2019;6:131.

CAS  PubMed  PubMed Central  Google Scholar 

Han Y, Wang Y, Dong X, Sun D, Liu Z, Yue J, et al. TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment. Nucleic Acids Res. 2023;51:D1425–D1431.

Yoshihara K, Shahmoradgoli M, Martínez E, Vegesna R, Kim H, Torres-Garcia W, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612.

PubMed  Google Scholar 

Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39:782–95.

CAS  PubMed  Google Scholar 

Baker KJ, Brint E, Houston A. Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/IL-23 axis. Br J Cancer. 2023;128:735–47.

CAS  PubMed  Google Scholar 

Bakshi HA, Quinn GA, Nasef MM, Mishra V, Aljabali AAA, El-Tanani M, et al. Crocin inhibits angiogenesis and metastasis in colon cancer via TNF-α/NF-kB/VEGF pathways. Cells. 2022;11:1502.

CAS  PubMed  PubMed Central  Google Scholar 

Perez-Ruiz E, Minute L, Otano I, Alvarez M, Ochoa MC, Belsue V, et al. Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy. Nature. 2019;569:428–32.

CAS  PubMed  Google Scholar 

Lin F, Zhang G, Yang X, Wang M, Wang R, Wan M, et al. A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K/AKT signaling pathway. J Ethnopharmacol. 2023;303:115933.

CAS  PubMed  Google Scholar 

Lin Y, Cheng L, Liu Y, Wang Y, Wang Q, Wang HL, et al. Intestinal epithelium-derived BATF3 promotes colitis-associated colon cancer through facilitating CXCL5-mediated neutrophils recruitment. Mucosal Immunol. 2021;14:187–98.

CAS  PubMed  Google Scholar 

He L, Kang Q, Chan KI, Zhang Y, Zhong Z, Tan W. The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer. Front Immunol. 2022;13:1093990.

CAS  PubMed  Google Scholar 

Klupp F, Neumann L, Kahlert C, Diers J, Halama N, Franz C, et al. Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients. BMC Cancer. 2016;16:494.

PubMed  PubMed Central  Google Scholar 

Zhao T, Su Z, Li Y, Zhang X, You Q. Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduct Target Ther. 2020;5:201.

CAS  PubMed  PubMed Central  Google Scholar 

Liu K, Jin M, Ye S, Yan S. CHI3L1 promotes proliferation and improves sensitivity to cetuximab in colon cancer cells by down-regulating p53. J Clin Lab Anal. 2020;34:e23026.

PubMed  Google Scholar 

Gao Y, Li J, Cheng W, Diao T, Liu H, Bo Y, et al. Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation. Cancer Cell. 2024;42:1764–1783.e10.

CAS  PubMed  Google Scholar 

Camargo MC, Song M, Sawada N, Inoue M, Shimazu T, Charvat H, et al. Prediagnostic circulating inflammation-related biomarkers and gastric cancer: a case-cohort study in Japan. Cytokine. 2021;144:155558.

CAS  PubMed  Google Scholar 

Comments (0)

No login
gif