Ning L, Xi J, Zi Y, Chen M, Zou Q, Zhou X, et al. Prospects and challenges of CRISPR/Cas9 gene-editing technology in cancer research. Clin Genet. 2023;104:613–24.

Article  CAS  PubMed  Google Scholar 

Carrera-Pacheco SE, Mueller A, Puente-Pineda JA, Zúñiga-Miranda J, Guamán LP. Designing cytochrome P450 enzymes for use in cancer gene therapy. Front Bioeng Biotechnol. 2024;12:1405466.

Belete TM. The current status of gene therapy for the treatment of cancer. Biol Targets Ther. 2021;15:67–77.

Article  Google Scholar 

Rauf MA, Rao A, Sivasoorian SS, Iyer AK. Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment: a comprehensive review. Cells. 2025;14:1–22.

Article  Google Scholar 

Zhou S, Li Y, Wu Q, Gong C. Nanotechnology-based CRISPR/Cas9 delivery system for genome editing in cancer treatment. MedComm – Biomater Appl, 2024;3: e70.

Dai X, Blancafort P, Wang P, Sgro A, Thompson EW, Ostrikov KK. Innovative precision gene-editing tools in personalized cancer medicine. Adv Sci. 2020;7:1902552.

Article  CAS  Google Scholar 

Paunovska K, Loughrey D, Dahlman JE. Drug delivery systems for RNA therapeutics. Nat Rev Genet. 2022;23:265–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Madry H, Venkatesan JK, Carballo-Pedrares N, Rey-Rico A, Cucchiarini M. Scaffold-Mediated Gene Delivery for Osteochondral Repair. Pharmaceutics. 2020;12:930.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tasset A, Bellamkonda A, Wang W, Pyatnitskiy I, Ward D, Peppas N, et al. Overcoming barriers in non-viral gene delivery for neurological applications. Nanoscale. 2022;14:3698–719.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shende P, Trivedi R. 3D printed bioconstructs: regenerative modulation for genetic expression. Stem Cell Rev Rep. 2021;17:1239–50.

Article  PubMed  PubMed Central  Google Scholar 

Jeleriu RM, Hajaj RK, Trăilă IA, Zaharie M, Puiu M. Theoretical models and simulations of gene delivery with polyurethane: the importance of polyurethane as a vector in personalized therapy. Biomed. 2025;13:692.

Taha BA, Addie AJ, Saeed AQ, Haider AJ, Chaudhary V, Arsad N. Nanostructured photonics Probes: A transformative approach in neurotherapeutics and brain circuitry. Neuroscience https://doi.org/10.1016/j.neuroscience.2024.10.046 (2024).

Taha BA, Addie AJ, Chahal S, Haider AJ, Rustagi S, Arsad N, et al. Unlocking new frontiers in healthcare: The impact of nano-optical biosensors on personalized medical diagnostics. J Biotechnol. 2025;400:29–47.

Article  CAS  PubMed  Google Scholar 

Taha, BA, Kadhim, AC, Addie, AJ, Al-Jubouri, Q, Azzahrani, AS, Haider, AJ, et al. Optical spectroscopy of cerebral blood flow for tissue interrogation in ischemic stroke diagnosis. ACS Chem Neurosci https://doi.org/10.1021/acschemneuro.4c00809 (2025).

Huang CH, Lee KC, Doudna JA. Applications of CRISPR-Cas enzymes in cancer therapeutics and detection. Trends Cancer. 2018;4:499–512.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Wang G, Yu X, Wei T, Farbiak L, Johnson LT, et al. Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy. Nat Nanotechnol. 2022;17:777–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu K, Xiang J, Wang G, Xu H, Piao Y, Liu X, et al. Linear-dendritic polymer-platinum complexes forming well-defined nanocapsules for acid-responsive drug delivery. ACS Appl Mater Interfaces. 2021;13:44028–40.

Article  CAS  PubMed  Google Scholar 

Liu K, Cui JJ, Zhan Y, Ouyang QY, Lu QS, Yang DH, et al. Reprogramming the tumor microenvironment by genome editing for precision cancer therapy. Mol Cancer. 2022;21:1–23.

Article  CAS  Google Scholar 

Zhao J, Yang H, Li J, Wang Y, Wang X. Fabrication of pH-responsive PLGA(UCNPs/DOX) nanocapsules with upconversion luminescence for drug delivery. Sci Rep. 2017;7:1–11.

Article  Google Scholar 

Xie Y, Yang Z, Shen H, Chen J, Weitz DA, Chen D, et al. Interfacial engineering of biocompatible nanocapsules for near-infrared-triggered drug release and photothermal therapy. Adv Sci 2025;12:2410844.

Naveed M, Tabassum N, Aziz T, Shabbir MA, Alkhateeb MA, Alghamdi S, et al. CRISPR-Cas9 guided RNA-based model for the silencing of spinal bulbar muscular atrophy: A functional genetic disorder. Cell Mol Biol. 2024;70:74–80.

Article  PubMed  Google Scholar 

Liu K, Chen YY, Li XY, Li QM, Pan LH, Luo JP, et al. Hydrolytic Quinoa protein and cationic lotus root starch-based micelles for co-delivery of Quercetin and Epigallo-catechin 3-Gallate in Ulcerative Colitis Treatment. J Agric Food Chem. 2022;70:15189–201.

Article  CAS  PubMed  Google Scholar 

Tabare E, Dauchot T, Cochez C, Glonti T, Antoine C, Laforêt F, et al. Eudragit® FS microparticles containing bacteriophages, prepared by spray-drying for oral administration. Pharmaceutics. 2023;15:1602.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Li M, Zhang G, Gao C, Wang S, Zhang T, et al. Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): a novel approach for colon-targeted oral delivery of Berberine. Mol Pharm. 2021;18:1573–81.

Article  CAS  PubMed  Google Scholar 

Bukhovets AV, Fotaki N, Khutoryanskiy VV, Moustafine RI. Interpolymer complexes of eudragit® copolymers as novel carriers for colon-specific drug delivery. Polymer. 2020;12:1–16.

Google Scholar 

Kalele K, Nyahatkar S, Mirgh D, Muthuswamy R, Adhikari MD, Anand K. Exosomes: a cutting-edge theranostics tool for oral cancer. ACS Appl Bio Mater. 2024;7:1400–15.

Article  CAS  PubMed  Google Scholar 

Soares LA, Crema E. Study of a delayed-release system for hard and soft capsules coated with eudragit® s100 acrylic polymers. Acta Sci - Heal Sci. 2020;42:1–10.

Google Scholar 

Souto EB, da Ana R, Souto SB, Zielińska A, Marques C, Andrade LN, et al. In vitro characterization, modelling, and antioxidant properties of polyphenon-60 from green tea in Eudragit S100-2 Chitosan Microspheres. Nutrients. 2020;12:967.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu S, Piao H, Rejinold NS, Lee H, Choi G, Choy JH. pH-responsive inorganic/organic nanohybrids system for controlled nicotinic acid drug release. Molecul. 2022;27:6439.

Heikal EJ, Kaoud RM, Gad S, Mokhtar HI, Alattar A, Alshaman R, et al. Development of novel pH-sensitive eudragit coated beads containing curcumin-mesalamine combination for colon-specific drug delivery. Gels 2023;9:264.

Tajau R, Rohani R, Abdul Hamid SS, Adam Z, Mohd Janib SN, Salleh MZ. Surface functionalisation of poly-APO-b-polyol ester cross-linked copolymers as core–shell nanoparticles for targeted breast cancer therapy. Sci Rep. 2020;10:1–17.

Article  Google Scholar 

Hapuarachchige S, Artemov D. Theranostic pretargeting drug delivery and imaging platforms in cancer precision medicine. Front Oncol. 2020;10:1–8.

Article  Google Scholar 

Parra-Nieto J, del Cid MAG, de Cárcer IA, Baeza A. Inorganic porous nanoparticles for drug delivery in antitumoral therapy. Biotechnol J. 2021;16:2000150.

Article  CAS  Google Scholar 

Dattilo M, Patitucci F, Prete S, Parisi OI, Puoci F. Polysaccharide-based hydrogels and their application as drug delivery systems in cancer treatment: a review. J Funct Biomater. 2023;14:55.

Ciolacu DE, Nicu R, Ciolacu F. Cellulose-based hydrogels as sustained drug-delivery systems. Materials. 2020;13:5270.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong H, Dai Q, Peng P. Cell-membrane-anchored DNA logic-gated nanoassemblies for in situ extracellular bioimaging. ACS Appl Mater Interfaces. 2022;14:43026–34.

Article  CAS  PubMed  Google Scholar 

Qian RC, Zhou ZR, Wu Y, Yang Z, Guo W, Li DW, et al. Combination cancer treatment: using engineered DNAzyme molecular machines for dynamic inter- and intracellular regulation. Angew Chem - Int Ed. 2022;61:e202210935.

Article  CAS  Google Scholar 

Dey S, Ahmed E, Somvanshi PS, Sina AA, Wuethrich A, Trau M. An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers. Chemosensors 2022;10:93.

Su J, Liu W, Chen S, Deng W, Dou Y, Zhao Z, et al. A carbon-based DNA framework nano–bio interface for biosensing with high sensitivity and a high signal-to-noise ratio. ACS Sens. 2020;5:3979–87.

Article  CAS  PubMed  Google Scholar 

Chen YL, Sun X, He JW, Xin MK, Liu D, Li CY. Light-driven and metal–organic framework synergetic loaded DNA tetrahedral amplifier for Exonuclease III-powered all-in-one biosensing and chemotherapy in live biosystems. ACS Appl Mater Interfaces. 2023;15:34311–20.

Article  CAS  PubMed  Google Scholar 

Wu Q, Wei X, Chen F, Huang M, Zhang S, Zhu L, et al. Aptamer-assisted blockade of the immune suppressor sialic acid-binding immunoglobulin-Like Lectin-15 for cancer immunotherapy. Angew Chem Int Ed. 2023;62:e202312609.

Article  CAS  Google Scholar