COL3A1 promotes gastric cancer progression by activating PI3K/AKT signaling

Tanaka K, Hirasawa T. Gastric adenocarcinoma and proximal polyposis of the stomach. N Engl J Med. 2025;392:e29.

Article  PubMed  Google Scholar 

Zhang X, Wang J, Wang G, Zhang Y, Fan Q, Lu C, et al. First-line sugemalimab plus chemotherapy for advanced gastric cancer: the GEMSTONE-303 randomized clinical trial. JAMA. 2025;333:1305–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen L, Zhang Y, Li Z, Zhang X, Gao X, Liu B. et al. First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial. Nat Med. 2025;31:1163–70.

Article  CAS  PubMed  Google Scholar 

Wizenty J, Sigal M. Helicobacter pylori, microbiota and gastric cancer-principles of microorganism-driven carcinogenesis. Nat Rev Gastroenterol Hepatol. 2025;22:296–313.

Article  PubMed  Google Scholar 

Ma H, Srivastava S, Ho SWT, Xu C, Lian BSX, Ong X, et al. Spatially resolved tumor ecosystems and cell states in gastric adenocarcinoma progression and evolution. Cancer Discov. 2025;15:767–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeoh KG, Tan P. Mapping the genomic diaspora of gastric cancer. Nat Rev Cancer. 2022;22:71–84.

Article  CAS  PubMed  Google Scholar 

An M, Mehta A, Min BH, Heo YJ, Wright SJ, Parikh M, et al. Early immune remodeling steers clinical response to first-line chemoimmunotherapy in advanced gastric cancer. Cancer Discov. 2024;14:766–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao X, Ji T, Liu A, Weng Y. ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis. Cell Death Dis. 2021;12:957.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao X, Liu T, Yu S, Wei Y, Zhou C, Kuai X. CEACAM6 facilitates gastric cancer progression through upregulating SLC27A2. Cancer Gene Ther. 2025;32:51–60.

Article  CAS  PubMed  Google Scholar 

Zhang B, Niu W, Dong HY, Liu ML, Luo Y, Li ZC. Hypoxia induces endothelial‑mesenchymal transition in pulmonary vascular remodeling. Int J Mol Med. 2018;42:270–8.

CAS  PubMed  PubMed Central  Google Scholar 

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, et al. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018;10.

Tanwar S, Trembling PM, Hogan BJ, Srivastava A, Parkes J, Harris S, et al. Noninvasive markers of liver fibrosis: on-treatment changes of serum markers predict the outcome of antifibrotic therapy. Eur J Gastroenterol Hepatol. 2017;29:289–96.

Article  CAS  PubMed  Google Scholar 

Su B, Zhao W, Shi B, Zhang Z, Yu X, Xie F, et al. Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7. Mol Cancer. 2014;13:206.

Article  PubMed  PubMed Central  Google Scholar 

Goncalves-Ribeiro S, Sanz-Pamplona R, Vidal A, Sanjuan X, Guillen Diaz-Maroto N, Soriano A, et al. Prediction of pathological response to neoadjuvant treatment in rectal cancer with a two-protein immunohistochemical score derived from stromal gene-profiling. Ann Oncol. 2017;28:2160–8.

Article  CAS  PubMed  Google Scholar 

Shen H, Wang L, Chen Q, Xu J, Zhang J, Fang L, et al. The prognostic value of COL3A1/FBN1/COL5A2/SPARC-mir-29a-3p-H19 associated ceRNA network in Gastric Cancer through bioinformatic exploration. J Cancer. 2020;11:4933–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan X, Xiao Y, Yu D. Turn cold tumors hot by reprogramming the tumor microenvironment. Nat Biotechnol. 2025;43:466–70.

Article  CAS  PubMed  Google Scholar 

Baghdadi MB, Houtekamer RM, Perrin L, Rao-Bhatia A, Whelen M, Decker L, et al. PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance. Science. 2024;386:eadj7615.

Article  CAS  PubMed  Google Scholar 

Miller EJ, Epstein EH Jr, Piez KA. Identification of three genetically distinct collagens by cyanogen bromide cleavage of insoluble human skin and cartilage collagen. Biochem Biophys Res Commun. 1971;42:1024–9.

Article  CAS  PubMed  Google Scholar 

Valkkila M, Melkoniemi M, Kvist L, Kuivaniemi H, Tromp G, Ala-Kokko L. Genomic organization of the human COL3A1 and COL5A2 genes: COL5A2 has evolved differently than the other minor fibrillar collagen genes. Matrix Biol. 2001;20:357–66.

Article  CAS  PubMed  Google Scholar 

Fagerberg L, Hallstrom BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, et al. Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteom. 2014;13:397–406.

Article  CAS  Google Scholar 

Lv W, Lin Y, Song W, Sun K, Yu H, Zhang Y, et al. Variants of COL3A1 are associated with the risk of stroke recurrence and prognosis in the Chinese population: a prospective study. J Mol Neurosci. 2014;53:196–203.

Article  CAS  PubMed  Google Scholar 

Hosseini ST, Nemati F. Identification of GUCA2A and COL3A1 as prognostic biomarkers in colorectal cancer by integrating analysis of RNA-Seq data and qRT-PCR validation. Sci Rep. 2023;13:17086.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duval E, Leclercq S, Elissalde JM, Demoor M, Galera P, Boumediene K. Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes. Arthritis Rheum. 2009;60:3038–48.

Article  CAS  PubMed  Google Scholar 

Carpenter G, Cohen S. Human epidermal growth factor and the proliferation of human fibroblasts. J Cell Physiol. 1976;88:227–37.

Article  CAS  PubMed  Google Scholar 

Shen T, Gao K, Miao Y, Hu Z. Exogenous growth factors enhance the expression of cola1, cola3, and Elastin in fibroblasts via activating MAPK signaling pathway. Mol Cell Biochem. 2018;442:203–10.

Article  CAS  PubMed  Google Scholar 

Shaikh G, Zhang J, Perez-Aso M, Mediero A, Cronstein B. Adenosine A(2A) receptor promotes collagen type III synthesis via beta-catenin activation in human dermal fibroblasts. Br J Pharm. 2016;173:3279–91.

Article  CAS  Google Scholar 

Mi Y, Wang W, Lu J, Zhang C, Wang Y, Ying H, et al. Proteasome-mediated degradation of collagen III by cortisol in amnion fibroblasts. J Mol Endocrinol. 2018;60:45–54.

Article  CAS  PubMed  Google Scholar 

Habara M, Shimada M. Estrogen receptor alpha revised: expression, structure, function, and stability. Bioessays. 2022;44:e2200148.

Article  PubMed  Google Scholar 

Barone I, Brusco L, Fuqua SA. Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res. 2010;16:2702–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JK, Xu Y, Xu X, Keene DR, Gurusiddappa S, Liang X, et al. A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1. J Biol Chem. 2005;280:32512–20.

Article  CAS  PubMed  Google Scholar 

Wang XQ, Tang ZX, Yu D, Cui SJ, Jiang YH, Zhang Q, et al. Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 2016;7:8823–38.

Article  PubMed  PubMed Central 

Comments (0)

No login
gif