Moshé SL, Perucca E, Ryvlin P, Tomson T. Epilepsy: New advances. Lancet 2015, 385: 884–898.

PubMed  Google Scholar 

Plummer C, Vogrin SJ, Woods WP, Murphy MA, Cook MJ, Liley DTJ. Interictal and ictal source localization for epilepsy surgery using high-density EEG with MEG: A prospective long-term study. Brain 2019, 142: 932–951.

PubMed  PubMed Central  Google Scholar 

Ozbas-Gerçeker F, Redeker S, Boer K, Ozgüç M, Saygi S, Dalkara T. Serial analysis of gene expression in the hippocampus of patients with mesial temporal lobe epilepsy. Neuroscience 2006, 138: 457–474.

PubMed  Google Scholar 

Young MJ, Hsu KC, Lin TE, Chang WC, Hung JJ. The role of ubiquitin-specific peptidases in cancer progression. J Biomed Sci 2019, 26: 42.

PubMed  PubMed Central  Google Scholar 

Choi BJ, Park SA, Lee SY, Cha YN, Surh YJ. Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9. Sci Rep 2017, 7: 15918.

PubMed  PubMed Central  Google Scholar 

Beaudoin GMJ 3rd, Lee SH, Singh D, Yuan Y, Ng YG, Reichardt LF, et al. Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex. Nat Protoc 2012, 7: 1741–1754.

CAS  PubMed  Google Scholar 

Bajpe PK, van der Knaap JA, Demmers JAA, Bezstarosti K, Bassett A, van Beusekom HMM, et al. Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack. Mol Cell Biol 2008, 28: 1606–1615.

CAS  PubMed  Google Scholar 

Sako-Kubota K, Tanaka N, Nagae S, Meng W, Takeichi M. Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions. Mol Biol Cell 2014, 25: 3851–3860.

PubMed  PubMed Central  Google Scholar 

Anckar J, Bonni A. Regulation of neuronal morphogenesis and positioning by ubiquitin-specific proteases in the cerebellum. PLoS One 2015, 10: e0117076.

PubMed  PubMed Central  Google Scholar 

Yang J, Zhang L, Cao LL, Qi J, Li P, Wang XP, et al. microRNA-99a is a potential target for regulating hypothalamic synaptic plasticity in the peri/postmenopausal depression model. Cells 2019, 8: 1081.

CAS  PubMed  PubMed Central  Google Scholar 

Citri A, Malenka RC. Synaptic plasticity: Multiple forms, functions, and mechanisms. Neuropsychopharmacology 2008, 33: 18–41.

PubMed  Google Scholar 

Bell MK, Rangamani P. Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity. J Physiol 2023, 601: 3377–3402.

CAS  PubMed  Google Scholar 

Zhang X, Poo MM. Progress in neural plasticity. Sci China Life Sci 2010, 53: 322–329.

PubMed  Google Scholar 

Yang J, Jiang Q, Yu X, Xu T, Wang Y, Deng J, et al. STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons. CNS Neurosci Ther 2020, 26: 851–861.

CAS  PubMed  PubMed Central  Google Scholar 

du Sert NP, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol 2020, 18: e3000410.

Google Scholar 

Paxinos G, Franklin KBJ (2013) The Mouse Brain in Stereotaxic Coordinates, 4th edn. Academic Press, San Diego, pp 31–231.

Google Scholar 

Dhir A. Pentylenetetrazol (PTZ) kindling model of epilepsy. Curr Protoc Neurosci 2012, Chapter 9: Unit9.37.

Racine RJ. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972, 32: 281–294.

CAS  PubMed  Google Scholar 

Volosin M, Trotter C, Cragnolini A, Kenchappa RS, Light M, Hempstead BL, et al. Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. J Neurosci 2008, 28: 9870–9879.

CAS  PubMed  PubMed Central  Google Scholar 

Xu T, Yu X, Deng J, Ou S, Liu X, Wang T, et al. CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells. Cell Death Dis 2019, 10: 825.

PubMed  PubMed Central  Google Scholar 

Liu Y, Tian X, Ke P, Gu J, Ma Y, Guo Y, et al. KIF17 modulates epileptic seizures and membrane expression of the NMDA receptor subunit NR2B. Neurosci Bull 2022, 38: 841–856.

CAS  PubMed  PubMed Central  Google Scholar 

Maier W, Bednorz M, Meister S, Roebroek A, Weggen S, Schmitt U, et al. LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Mol Neurodegener 2013, 8: 25.

CAS  PubMed  PubMed Central  Google Scholar 

Egbenya DL, Hussain S, Lai YC, Xia J, Anderson AE, Davanger S. Changes in synaptic AMPA receptor concentration and composition in chronic temporal lobe epilepsy. Mol Cell Neurosci 2018, 92: 93–103.

CAS  PubMed  Google Scholar 

Lohmann C, Kessels HW. The developmental stages of synaptic plasticity. J Physiol 2014, 592: 13–31.

CAS  PubMed  Google Scholar 

Kolleker A, Julius Zhu J, Schupp BJ, Qin Y, Mack V, Borchardt T, et al. Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors. Neuron 2003, 40: 1199–1212.

CAS  PubMed  Google Scholar 

Yang SW, Oh KH, Park E, Chang HM, Park JM, Seong MW, et al. USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. J Neurosci 2013, 33: 12728–12738.

CAS  PubMed  PubMed Central  Google Scholar 

Allen Reference Atlas – Mouse Brain [brain atlas]. Available from https://atlas.brain-map.org/

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, et al. Proteomics tissue-based map of the human proteome. Science 2015, 347: 1260419.

PubMed  Google Scholar 

Yuste R, Bonhoeffer T. Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci 2001, 24: 1071–1089.

CAS  PubMed  Google Scholar 

Tian W, Peng L, Zhao M, Tao L, Zou P, Zhang Y. Dendritic morphology affects the velocity and amplitude of back-propagating action potentials. Neurosci Bull 2022, 38: 1330–1346.

CAS  PubMed  PubMed Central  Google Scholar 

Ehlers MD. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron 2000, 28: 511–525.

CAS  PubMed  Google Scholar 

Zhang D, Hou Q, Wang M, Lin A, Jarzylo L, Navis A, et al. Na, K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci 2009, 29: 4498–4511.

CAS  PubMed  PubMed Central  Google Scholar 

Rogawski MA. Revisiting AMPA receptors as an antiepileptic drug target. Epilepsy Curr 2011, 11: 56–63.

PubMed  PubMed Central  Google Scholar 

Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, et al. The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol 2019, 17: e3000525.

PubMed  PubMed Central  Google Scholar 

Huo Y, Khatri N, Hou Q, Gilbert J, Wang G, Man HY. The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking. J Neurochem 2015, 134: 1067–1080.

CAS  PubMed  PubMed Central  Google Scholar 

Tian QB, Okano A, Nakayama K, Miyazawa S, Endo S, Suzuki T. A novel ubiquitin-specific protease, synUSP, is localized at the post-synaptic density and post-synaptic lipid raft. J Neurochem 2003, 87: 665–675.

CAS  PubMed  Google Scholar 

Walters BJ, Campbell SL, Chen PC, Taylor AP, Schroeder DG, Dobrunz LE, et al. Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. Mol Cell Neurosci 2008, 39: 539–548.

CAS  PubMed  PubMed Central  Google Scholar 

Gong L, Han Y, Chen R, Yang P, Zhang C. LncRNA ZNF883-mediated NLRP3 inflammasome activation and epilepsy development involve USP47 upregulation. Mol Neurobiol 2022, 59: 5207–5221.

CAS  PubMed  Google Scholar 

Ning YJ, Wang M, Deng M, Shen S, Liu W, Cao WC, et al. Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform. J Mol Cell Biol 2014, 6: 324–337.

CAS  PubMed  Google Scholar 

Böhme MA, McCarthy AW, Grasskamp AT, Beuschel CB, Goel P, Jusyte M, et al. Rapid active zone remodeling consolidates presynaptic potentiation. Nat Commun 2019, 10: 1085.