FitzGerald JD. Gout. Ann Intern Med 2025, 178: ITC33–ITC48.
Abhishek A, Roddy E, Doherty M. Gout–a guide for the general and acute physicians. Clin Med 2017, 17: 54–59.
Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440: 237–241.
Article CAS PubMed Google Scholar
Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castaneda J. 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. Ann Rheum Dis 2020, 79: 31–38.
Dalbeth N, Choi HK, Joosten LAB, Khanna PP, Matsuo H, Perez-Ruiz F, et al. Gout. Nat Rev Dis Primers 2019, 5: 69.
Kuo CF, Grainge MJ, Zhang W, Doherty M. Global epidemiology of gout: Prevalence, incidence and risk factors. Nat Rev Rheumatol 2015, 11: 649–662.
Peng X, Li X, Xie B, Lai Y, Sosnik A, Boucetta H, et al. Gout therapeutics and drug delivery. J Control Release 2023, 362: 728–754.
Article CAS PubMed Google Scholar
Latourte A, Bardin T, Richette P. Prophylaxis for acute gout flares after initiation of urate-lowering therapy. Rheumatology (Oxford) 2014, 53: 1920–1926.
Article CAS PubMed Google Scholar
Yao TK, Lee RP, Wu WT, Chen IH, Yu TC, Yeh KT. Advances in gouty arthritis management: Integration of established therapies, emerging treatments, and lifestyle interventions. Int J Mol Sci 2024, 25: 10853.
Article CAS PubMed PubMed Central Google Scholar
Johnson RJ, Mandell BF, Schlesinger N, Mount DB, Botson JK, Abdellatif AA, et al. Controversies and practical management of patients with gout and chronic kidney disease. Kidney Int 2024, 106: 573–582.
Article CAS PubMed Google Scholar
Butt JH, Docherty KF, Claggett BL, Desai AS, Petersson M, Langkilde AM, et al. Association of dapagliflozin use with clinical outcomes and the introduction of uric acid-lowering therapy and colchicine in patients with heart failure with and without gout: A patient-level pooled meta-analysis of DAPA-HF and DELIVER. JAMA Cardiol 2023, 8: 386–393.
Article PubMed PubMed Central Google Scholar
Xu H, Zhang B, Chen Y, Zeng F, Wang W, Chen Z, et al. Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment. Ann Rheum Dis 2023, 82: 416–427.
Article CAS PubMed Google Scholar
Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, et al. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell 2015, 160: 62–73.
Article CAS PubMed Google Scholar
Rose DM, Liu-Bryan R. Innate immunity in triggering and resolution of acute gouty inflammation. Curr Rheumatol Rep 2006, 8: 209–214.
Article CAS PubMed Google Scholar
Yang J, Li S, Li Z, Yao L, Liu M, Tong KL, et al. Targeting YAP1-regulated glycolysis in fibroblast-like synoviocytes impairs macrophage infiltration to ameliorate diabetic osteoarthritis progression. Adv Sci (Weinh) 2024, 11: e2304617.
Hanlon MM, Smith CM, Canavan M, Neto NGB, Song Q, Lewis MJ, et al. Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset. Sci Adv 2024, 10: eadj1252.
Article CAS PubMed PubMed Central Google Scholar
Flores AM, Hosseini-Nassab N, Jarr KU, Ye J, Zhu X, Wirka R, et al. Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis. Nat Nanotechnol 2020, 15: 154–161.
Article CAS PubMed PubMed Central Google Scholar
Lan Z, Chen L, Feng J, Xie Z, Liu Z, Wang F, et al. Mechanosensitive TRPV4 is required for crystal-induced inflammation. Ann Rheum Dis 2021, 80: 1604–1614.
Article CAS PubMed PubMed Central Google Scholar
Cheng JJ, Ma XD, Ai GX, Yu QX, Chen XY, Yan F, et al. Palmatine protects against MSU-induced gouty arthritis via regulating the NF-κB/NLRP3 and Nrf2 pathways. Drug Des Devel Ther 2022, 16: 2119–2132.
Article PubMed PubMed Central Google Scholar
Leask MP, Crișan TO, Ji A, Matsuo H, Köttgen A, Merriman TR. The pathogenesis of gout: Molecular insights from genetic, epigenomic and transcriptomic studies. Nat Rev Rheumatol 2024, 20: 510–523.
Schlesinger N, Pillinger MH, Simon LS, Lipsky PE. Interleukin-1β inhibitors for the management of acute gout flares: A systematic literature review. Arthritis Res Ther 2023, 25: 128.
Article CAS PubMed PubMed Central Google Scholar
Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, et al. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature 2017, 542: 110–114.
Article CAS PubMed PubMed Central Google Scholar
Rana AK, Li Y, Dang Q, Yang F. Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and their heterogeneity and plasticity role in RA pathogenesis. Int Immunopharmacol 2018, 65: 348–359.
Article CAS PubMed Google Scholar
Tu J, Hong W, Guo Y, Zhang P, Fang Y, Wang X, et al. Ontogeny of synovial macrophages and the roles of synovial macrophages from different origins in arthritis. Front Immunol 2019, 10: 1146.
Article CAS PubMed PubMed Central Google Scholar
Ma S, Dubin AE, Zhang Y, Mousavi SAR, Wang Y, Coombs AM, et al. A role of PIEZO1 in iron metabolism in mice and humans. Cell 2021, 184: 969-982.e13.
Article CAS PubMed PubMed Central Google Scholar
Zhou R, Fu W, Vasylyev D, Waxman SG, Liu CJ. Ion channels in osteoarthritis: Emerging roles and potential targets. Nat Rev Rheumatol 2024, 20: 545–564.
Article CAS PubMed PubMed Central Google Scholar
Ran L, Ye T, Erbs E, Ehl S, Spassky N, Suara I, et al. KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation. Sci Immunol 2023, 8: eadf4699.
Article CAS PubMed Google Scholar
Gan D, Tao C, Jin X, Wu X, Yan Q, Zhong Y, et al. Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin. J Adv Res 2024, 62: 105–117.
Article CAS PubMed Google Scholar
Han S. Osteoarthritis year in review 2022: Biology. Osteoarthritis Cartilage 2022, 30: 1575–1582.
Article CAS PubMed Google Scholar
Liu Y, Zhang Z, Li J, Chang B, Lin Q, Wang F, et al. Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity. Mech Ageing Dev 2023, 216: 111880.
Article CAS PubMed Google Scholar
Brylka LJ, Alimy AR, Tschaffon-Müller MEA, Jiang S, Ballhause TM, Baranowsky A, et al. Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development. Bone Res 2024, 12: 12.
Comments (0)