Südhof TC. Neurotransmitter release: The last millisecond in the life of a synaptic vesicle. Neuron 2013, 80: 675–690.

Article  PubMed  PubMed Central  Google Scholar 

Sudhof TC, Rizo J. Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol 2011, 3: a005637.

Article  PubMed  PubMed Central  Google Scholar 

Li L, Liu H, Wang W, Chandra M, Collins BM, Hu Z. SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans. J Neurosci 2018, 38: 5313–5324.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji E, Zhang Y, Li Z, Wei L, Wu Z, Li Y. The chemokine CCL2 promotes excitatory synaptic transmission in hippocampal neurons via GluA1 subunit trafficking. Neurosci Bull 2024, 40: 1649–1666.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Südhof TC. Calcium control of neurotransmitter release. Cold Spring Harb Perspect Biol 2012, 4: a011353.

Article  PubMed  PubMed Central  Google Scholar 

Katz B, Miledi R. Ionic requirements of synaptic transmitter release. Nature 1967, 215: 651.

Article  CAS  PubMed  Google Scholar 

Bacaj T, Wu D, Yang X, Morishita W, Zhou P, Xu W, et al. Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release. Neuron 2013, 80: 947–959.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pang ZP, Südhof TC. Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol 2010, 22: 496–505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sforna L, Franciolini F, Catacuzzeno L. Ca2+-dependent and Ca2+-independent somatic release from trigeminal neurons. J Cell Physiol 2019, 234: 10977–10989.

Article  CAS  PubMed  Google Scholar 

Zhang C, Zhou Z. Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nat Neurosci 2002, 5: 425–430.

Article  CAS  PubMed  Google Scholar 

Wang Y, Huang R, Chai Z, Wang C, Du X, Hang Y, et al. Ca2+-independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Rep 2022, 23: e54507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang R, Wang Y, Li J, Jiang X, Li Y, Liu B, et al. Ca2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system. Proc Natl Acad Sci USA 2019, 116: 20201–20209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moya-Díaz J, Bayonés L, Montenegro M, Cárdenas AM, Koch H, Doi A, et al. Ca2+-independent and voltage-dependent exocytosis in mouse chromaffin cells. Acta Physiol 2020, 228: e13417.

Article  Google Scholar 

Chai Z, Wang C, Huang R, Wang Y, Zhang X, Wu Q, et al. Ca(V)2.2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons. Neuron 2017, 96: 1317–1326.

Article  CAS  PubMed  Google Scholar 

Lipscombe D, Kongsamut S, Tsien RW. Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating. Nature 1989, 340: 639–642.

Article  CAS  PubMed  Google Scholar 

Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Touma E, Metzger RE, et al. P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol 1999, 82: 1590–1598.

Article  CAS  PubMed  Google Scholar 

Zheng H, Fan J, Xiong W, Zhang C, Wang XB, Liu T, et al. Action potential modulates Ca2+-dependent and Ca2+-independent secretion in a sensory neuron. Biophys J 2009, 96: 2449–2456.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Xiong W, Zheng H, Wang L, Lu B, Zhou Z. Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons. Neuron 2004, 42: 225–236.

Article  CAS  PubMed  Google Scholar 

Lindau M, Neher E. Patch-clamp techniques for time-resolved capacitance measurements in single cells. Pflugers Arch 1988, 411: 137–146.

Article  CAS  PubMed  Google Scholar 

Zhang B, Zhang XY, Luo PF, Huang W, Zhu FP, Liu T, et al. Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices. J Physiol 2012, 590: 753–762.

Article  CAS  PubMed  Google Scholar 

Wang Y, Wu Q, Hu M, Liu B, Chai Z, Huang R, et al. Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Sci Signal 2017, 10: eaal1683.

Article  PubMed  Google Scholar 

Poulter NS, Pitkeathly WTE, Smith PJ, Rappoport JZ. The physical basis of total internal reflection fluorescence (TIRF) microscopy and its cellular applications. Methods Mol Biol 2015, 1251: 1–23.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Yao J, Huo J, Wang R, Duan X, Chen Y, et al. Action potential-independent spontaneous microdomain Ca2+ transients-mediated continuous neurotransmission regulates hyperalgesia. Proc Natl Acad Sci USA 2025, 122: e2406741122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang R, Lu Y, Zhao J, Duan X, Chen Y, Zhang Z, et al. A combined protocol for isolation, culture, and patch-clamp recording of dorsal root ganglion neurons. Biophys Rep 2025, 11: 87–95.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z, Huang R. Stronger stimulus triggers synaptic transmission faster through earlier started action potential. Cell Commun Signal 2024, 22: 34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Li L, Wang W, Gong J, Yang X, Hu Z. Spontaneous vesicle fusion is differentially regulated at cholinergic and GABAergic synapses. Cell Rep 2018, 22: 2334–2345.

Article  CAS  PubMed  Google Scholar 

Liu H, Li L, Sheoran S, Yu Y, Richmond JE, Xia J, et al. The M domain in UNC-13 regulates the probability of neurotransmitter release. Cell Rep 2021, 34: 108828.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Link E, Edelmann L, Chou JH, Binz T, Yamasaki S, Eisel U, et al. Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis. Biochem Biophys Res Commun 1992, 189: 1017–1023.

Article  CAS  PubMed  Google Scholar 

Blasi J, Chapman ER, Link E, Binz T, Yamasaki S, De Camilli P, et al. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. Nature 1993, 365: 160–163.

Article  CAS  PubMed  Google Scholar 

Blasi J, Chapman ER, Yamasaki S, Binz T, Niemann H, Jahn R. Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin. EMBO J 1993, 12: 4821–4828.

Article  CAS  PubMed  PubMed Central