Bosch-Queralt M, Fledrich R, Stassart RM. Schwann cell functions in peripheral nerve development and repair. Neurobiol Dis 2023, 176: 105952.

Article  CAS  PubMed  Google Scholar 

Hastings RL, Valdez G. Origin, identity, and function of terminal Schwann cells. Trends Neurosci 2024, 47: 432–446.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Logu F, Li Puma S, Landini L, Portelli F, Innocenti A, de Araujo DSM. Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice. J Clin Invest 2019, 129: 5424–5441.

Article  PubMed  PubMed Central  Google Scholar 

Zhang SH, Shurin GV, Khosravi H, Kazi R, Kruglov O, Shurin MR, et al. Immunomodulation by schwann cells in disease. Cancer Immunol Immunother 2020, 69: 245–253.

Article  PubMed  Google Scholar 

Ciotu CI, Kistner K, Kaindl U, Millesi F, Weiss T, Radtke C, et al. Schwann cell stimulation induces functional and structural changes in peripheral nerves. Glia 2023, 71: 945–956.

Article  CAS  PubMed  Google Scholar 

Ma Q, Su D, Huo J, Yin G, Dong D, Duan K, et al. Microglial depletion does not affect the laterality of mechanical allodynia in mice. Neurosci Bull 2023, 39: 1229–1245.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ojeda-Alonso J, Calvo-Enrique L, Paricio-Montesinos R, Kumar R, Zhang MD, Poulet JFA, et al. Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception. Nat Commun 2024, 15: 898.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raut NG, Maile LA, Oswalt LM, Mitxelena I, Adlakha A, Sprague KL, et al. Schwann cells modulate nociception in neurofibromatosis 1. JCI Insight 2024, 9: e171275.

Article  PubMed  PubMed Central  Google Scholar 

Gambarotto L, Russo L, Bresolin S, Persano L, D’Amore R, Ronchi G, et al. Schwann cell-specific ablation of beclin 1 impairs myelination and leads to motor and sensory neuropathy in mice. Adv Sci 2025, 12: 2308965.

Article  CAS  Google Scholar 

Abdo H, Calvo-Enrique L, Lopez JM, Song J, Zhang MD, Usoskin D, et al. Specialized cutaneous Schwann cells initiate pain sensation. Science 2019, 365: 695–699.

Article  CAS  PubMed  Google Scholar 

De Logu F, Nassini R, Hegron A, Landini L, Jensen DD, Latorre R, et al. Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice. Nat Commun 2022, 13: 646.

Article  PubMed  PubMed Central  Google Scholar 

Fattori V, Zaninelli TH, Rasquel-Oliveira FS, Heintz OK, Jain A, Sun L, et al. Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice. Sci Transl Med 2024, 16: eadk8230.

Article  CAS  PubMed  Google Scholar 

Bagheri H, Friedman H, Hadwen A, Jarweh C, Cooper E, Oprea L, et al. Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells. Glia 2024, 72: 1893–1914.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chesnut M, Paschoud H, Repond C, Smirnova L, Hartung T, Zurich MG, et al. Human IPSC-derived model to study myelin disruption. Int J Mol Sci 2021, 22: 9473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Susaki EA, Tainaka K, Perrin D, Kishino F, Tawara T, Watanabe TM, et al. Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis. Cell 2014, 157: 726–739.

Article  CAS  PubMed  Google Scholar 

Burek DJ, Massaly N, Yoon HJ, Doering M, Morón JA. Behavioral outcomes of complete Freund adjuvant-induced inflammatory pain in the rodent hind paw: A systematic review and meta-analysis. Pain 2022, 163: 809–819.

Article  PubMed  PubMed Central  Google Scholar 

Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33: 87–107.

Article  PubMed  Google Scholar 

Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: A simple, rapid method to immunolabel large tissue samples for volume imaging. Cell 2014, 159: 896–910.

Article  CAS  PubMed  Google Scholar 

Xu ZZ, Zhang L, Liu T, Park JY, Berta T, Yang R, et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med 2010, 16: 592–597.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Lin JJ, Xie YK, Song XZ, Sun JY, Zhang BL, et al. Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia. Nat Commun 2023, 14: 4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Wu H, Xie S, Zhu F, Xu F, Xu Q, et al. GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain. Elife 2025, 13: RP102874.

Article  PubMed  PubMed Central  Google Scholar 

Xia LP, Luo H, Ma Q, Xie YK, Li W, Hu H, et al. GPR151 in nociceptors modulates neuropathic pain via regulating P2X3 function and microglial activation. Brain 2021, 144: 3405–3420.

Article  PubMed  Google Scholar 

Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 1980, 20: 441–462.

Article  CAS  PubMed  Google Scholar 

Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu JB, et al. Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis. Cell Rep 2025, 44: 115266.

Article  CAS  PubMed  Google Scholar 

Xie YK, Luo H, Zhang SX, Chen XY, Guo R, Qiu XY, et al. GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation. Sci Transl Med 2022, 14: eabh2557.

Article  CAS  PubMed  Google Scholar 

Choi S, Hachisuka J, Brett MA, Magee AR, Omori Y, Iqbal NUA, et al. Parallel ascending spinal pathways for affective touch and pain. Nature 2020, 587: 258–263.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chamessian A, Matsuda M, Young M, Wang M, Zhang ZJ, Liu D, et al. Is optogenetic activation of Vglut1-positive aβ low-threshold mechanoreceptors sufficient to induce tactile allodynia in mice after nerve injury? J Neurosci 2019, 39: 6202–6215.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hua T, Chen B, Lu D, Sakurai K, Zhao S, Han BX, et al. General anesthetics activate a potent central pain-suppression circuit in the amygdala. Nat Neurosci 2020, 23: 854–868.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, et al. Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination. Neuron 2017, 93: 179–193.

Article  CAS  PubMed  Google Scholar 

Roberson DP, Gudes S, Sprague JM, Patoski HAW, Robson VK, Blasl F, et al. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci 2013, 16: 910–918.

Article  CAS