Newell LF, Cook RJ. Advances in acute myeloid leukemia. BMJ. 2021;375:n2026.

Döhner H, Weisdorf DJ, Bloomfield CD. Acute Myeloid Leukemia. New England J Med. 2015;373(12):1136–52. https://doi.org/10.1056/NEJMra1406184

Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, et al. Commentary the world health organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Ann Oncol. 1999;10:1.

Article  Google Scholar 

Dinardo CD, Wei AH. How i treat acute myeloid leukemia in the era of new drugs. Blood. 2020. https://doi.org/10.1182/blood.2019001239.

Article  PubMed  PubMed Central  Google Scholar 

Yanada M, Konuma T, Yamasaki S, Kondo T, Fukuda T, Shingai N, et al. Relapse of acute myeloid leukemia after allogeneic hematopoietic cell transplantation: clinical features and outcomes. Bone Marrow Transplant. 2021;56(5):1126–33.

Article  CAS  PubMed  Google Scholar 

Ali SA, Peffers MJ, Ormseth MJ, Jurisica I, Kapoor M. The non-coding RNA interactome in joint health and disease. Nat Rev Rheumatol Nat Res. 2021;17:692–705.

Article  CAS  Google Scholar 

Yan H, Bu P. Non-coding RNA in cancer. In: Essays in Biochemistry, vol. 65. Portland Press Ltd.; 2021. p. 625–39.

Google Scholar 

Guo B, Li D, Du L, Zhu X. piRNAs: biogenesis and their potential roles in cancer. Cancer Metastasis Rev. 2020;39:567–75.

Article  PubMed  Google Scholar 

Müller M, Fazi F, Ciaudo C. Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination. Front Cell Dev Biol. 2020;7:1.

Article  Google Scholar 

Gebert D, Ketting RF, Zischler H, Rosenkranz D. piRNAs from pig testis provide evidence for a conserved role of the Piwi pathway in post-transcriptional gene regulation in mammals. PLoS One. 2015;10(5):1.

Article  Google Scholar 

Russell SJ, LaMarre J. Transposons and the PIWI pathway: genome defense in gametes and embryos.Reproduction.2018;156(4):R111–R24.

Balmeh N, Mahmoudi S, Karabedianhajiabadi A. piRNAs and PIWI proteins: From biogenesis to their role in cancer. Gene Reports. 2021;22:1.

Article  Google Scholar 

Weick EM, Miska EA. piRNAs: From biogenesis to function. Development. 2014;141:3458–71.

Article  CAS  PubMed  Google Scholar 

Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, et al. A Role for Fkbp6 and the Chaperone Machinery in piRNA Amplification and Transposon Silencing. Mol Cell. 2012;47(6):970–9.

Article  CAS  PubMed  Google Scholar 

Brennecke J, Malone CD, Aravin AA, Sachidanandam R, Stark A, Hannon GJ. An epigenetic role for maternally inherited piRNAs in transposon silencing. Science. 2008;322(5906):1387–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Borja E, Siegl F, Mateu R, Slaby O, Sedo A, Busek P, et al. Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells. Biomarker Res. 2024;12:1.

Article  Google Scholar 

Peng Q, Chen Y, Xie T, Pu D, Ho VWS, Sun J, et al. PiRNA-4447944 promotes castration-resistant growth and metastasis of prostate cancer by inhibiting NEFH expression through forming the piRNA-4447944-PIWIL2-NEFH complex. Int J Biol Sci. 2024;20(9):3638–55.

Article  PubMed  PubMed Central  Google Scholar 

Mai D, Zheng Y, Guo H, Ding P, Bai R, Li M, et al. Serum piRNA-54265 is a new biomarker for early detection and clinical surveillance of human colorectal cancer. Theranostics. 2020;10(19):8468–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma W, Xu L, Wang Y, Chen S, Li D, Huo X, et al. piR-27222 mediates PM2.5-induced lung cancer by resisting cell PANoptosis through the WTAP/m6A axis. Environ Int. 2024;190:1.

Article  Google Scholar 

Ghaseminezhad Z, Sharifi M, Bahreini A, Mehrzad V. Investigation of the expression of P-element-induced wimpy testis-interacting RNAs in human acute myeloid leukemia. Meta Gene. 2022;1:31.

Google Scholar 

Quemener AM, Bachelot L, Forestier A, Donnou-Fournet E, Gilot D, Galibert MD. The powerful world of antisense oligonucleotides: From bench to bedside, vol. 11. RNA. Blackwell Publishing Ltd; 2020.

Google Scholar 

Hagedorn PH, Persson R, Funder ED, Albæk N, Diemer SL, Hansen DJ, et al. (2018) Locked nucleic acid modality diversity and drug discovery. Drug Discovery Today. 23: 101-14.

Papargyri N, Pontoppidan M, Andersen MR, Koch T, Hagedorn PH. Chemical diversity of locked nucleic acid-modified antisense oligonucleotides allows optimization of pharmaceutical properties. Mol Ther Nucleic Acids. 2020;6(19):706–17.

Article  Google Scholar 

Li P, Zhou L, Zhao T, Liu X, Zhang P, Liu Y, et al. Caspase-9: structure, mechanisms and clinical application [Internet]. Oncotarget. 2017;8:1.

Google Scholar 

Zhou M, Liu X, Li Z, Huang Q, Li F, Li CY. Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. Int J Cancer. 2018;143(4):921–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Man N, Tan Y, Liu F, Cheng G, Greenblatt SM, Martinez C, et al. Caspase-3 Can Promote Acute Myeloid Leukemia Development By Regulation of Autophagy. Blood. 2016;128(22):2714–2714.

Article  Google Scholar 

Ranjbarnejad T, Gholaminejad A, Sherkat R, Salehi M, Sharifi M. Decreased expression of hsa-miR-142-3p and hsa-miR-155-5p in patients with common variable immunodeficiency and involvement of their target genes and biological pathways [Internet]. 2024. Available from: https://www.researchsquare.com/article/rs-4736220/v1

Fasihi-Ramandi M, Moridnia A, Najafi A, Sharifi M. Inducing Apoptosis and Decreasing Cell Proliferation in Human Acute Promyelocytic Leukemia Through Regulation Expression of CASP3 by Let-7a-5p Blockage. Indian J Hematol Blood Trans. 2018;34(1):70–7.

Article  Google Scholar 

Sharifi M, Moridnia A. Apoptosis-inducing and antiproliferative effect by inhibition of miR-182-5p through the regulation of CASP9 expression in human breast cancer. Cancer Gene Ther. 2017;24(2):75–82.

Article  CAS  PubMed  Google Scholar 

Dabiri A, Sharifi M, Sarmadi A. Knockdown of SOX12 expression induced apoptotic factors is associated with TWIST1 and CTNNB1 expression in human Acute myeloid leukemia cells. Int J Mol Cell Med. 2022;10(4):249.

Ghadiri A, Sharifi M, Mehrzad V, Bagheri P. Reduce proliferation of human bone marrow cells from acute myeloblastic leukemia with minimally differentiation by blocking lncRNA PVT1. Clin Transl Oncol. 2020;22(11):2103–10.

Article  CAS  PubMed  Google Scholar 

Adhikary K, Ganguly K, Roy N, Bar P, Mahapatra S, Maiti R. Updated insights on clinical diagnosis and targeted therapy of acute myeloid leukaemia (AML): A molecular approach. Chem Biol Lett. 2025;12(2):1.

Article  Google Scholar 

Wachter F, Pikman Y. Pathophysiology of acute myeloid leukemia. Acta Haematol. 2024;147(2):229–46.

Zeng Q, Wan H, Zhao S, Xu H, Tang T, Oware KA, et al. Role of PIWI-interacting RNAs on cell survival: Proliferation, apoptosis, and cycle. IUBMB Life. 2020;72:1870–8.

Article  CAS  PubMed  Google Scholar 

Nasseri S, Sharifi M, Mehrzad V. Effects of hsa-piR-32877 suppression with antisense LNA gapmers on the proliferation and apoptosis of human acute myeloid leukemia cells. Int J Mol Cell Med. 2023;12(1):18–29.

PubMed  PubMed Central  Google Scholar 

D’Arcy MS. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 2019;43:582–92.

Article  PubMed  Google Scholar 

Silva MT. Secondary necrosis: the natural outcome of the complete apoptotic program. FEBS Lett. 2010;584:4491–9.

Article  CAS  PubMed  Google Scholar 

Vanden Berghe T, Grootjans S, Goossens V, Dondelinger Y, Krysko DV, Takahashi N, et al. Determination of apoptotic and necrotic cell death in vitro and in vivo. Methods. 2013;61(2):117–29.

Article  CAS  PubMed  Google Scholar