Leiphrakpam PD, Chowdhury S, Zhang M, Bajaj V, Dhir M, Are C. Trends in the global incidence of pancreatic cancer and a brief review of its histologic and molecular subtypes. J Gastrointest Cancer. 2025;56:71.
Juthani R, Manne A. Blood-based biomarkers in pancreatic ductal adenocarcinoma: developments over the last decade and what holds for the future—a review. Front Oncol. 2025;15:1555963.
Article PubMed PubMed Central Google Scholar
Liu B, Zhou H, Tan L, Siu KTH, Guan X-Y. Exploring treatment options in cancer: tumor treatment strategies. Signal Transduct Target Ther. 2024;9:175.
Article PubMed PubMed Central Google Scholar
Sadrinasab S, Saket S, Pourmohammadi N, Khosravi F, Fakhr MS. Modern therapeutic approaches for hepatic tumors: progress, limitations, and future directions. Discover Oncol. 2025;16:959.
Principe DR, Underwood PW, Korc M, Trevino JG, Munshi HG, Rana A. The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy. Front Oncol. 2021;11:2021.
Chunarkar-Patil P, Kaleem M, Mishra R, Ray S, Ahmad A, Verma D, et al. Anticancer drug discovery based on natural products: from computational approaches to clinical studies. Biomedicines. 2024. https://doi.org/10.3390/biomedicines12010201.
Article PubMed PubMed Central Google Scholar
Jiménez-González C, Agrasar AMT, Mallo F, Rúa ML, Fuciños C. Red seaweed proteins: Valuable marine-origin compounds with encouraging applications. Algal Res. 2023;75:103262.
Zhou Q-L, Wang Z, Chen W-T, Liu X-F, Cheong K-L, Zou Y-X, et al. The structural characteristics, biological activities and mechanisms of bioactive brown seaweed polysaccharides: a review. J Funct Foods. 2024;119:106303.
Mensah EO, Kanwugu ON, Panda PK, Adadi P. Marine fucoidans: Structural, extraction, biological activities and their applications in the food industry. Food Hydrocolloids. 2023;142:108784.
Turrini E, Maffei F, Fimognari C. Ten years of research on fucoidan and cancer: focus on its antiangiogenic and antimetastatic effects. Mar Drugs. 2023;21:307.
Article PubMed PubMed Central CAS Google Scholar
Zheng H, Zhao Y, Guo L. A bioactive substance derived from brown seaweeds: phlorotannins. Mar Drugs. 2022. https://doi.org/10.3390/md20120742.
Article PubMed PubMed Central Google Scholar
Simón L, Arazo-Rusindo M, Quest AFG, Mariotti-Celis MS. Phlorotannins: novel orally administrated bioactive compounds that induce mitochondrial dysfunction and oxidative stress in cancer. Antioxidants. 2023;12:1734.
Article PubMed PubMed Central Google Scholar
Goya L, Mateos R. Antioxidant and anti-inflammatory effects of marine phlorotannins and bromophenols supportive of their anticancer potential. Nutr Rev. 2025;83:e1225–42.
Matulja D, Vranješević F, Kolympadi Markovic M, Pavelić SK, Marković D. Anticancer activities of marine-derived phenolic compounds and their derivatives. Molecules. 2022;27:1449.
Article PubMed PubMed Central CAS Google Scholar
Haggag YA, Abd Elrahman AA, Ulber R, Zayed A. Fucoidan in pharmaceutical formulations: a comprehensive review for smart drug delivery systems. Mar Drugs. 2023;21:112.
Article PubMed PubMed Central CAS Google Scholar
Bang C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, et al. Metaorganisms in extreme environments: do microbes play a role in organismal adaptation? Zoology. 2018;127:1–19.
Ahmed N, Sheikh MA, Ubaid M, Chauhan P, Kumar K, Choudhary S. Comprehensive exploration of marine algae diversity, bioactive compounds, health benefits, regulatory issues, and food and drug applications. Measurement: Food. 2024;14:100163.
Nkurunziza D, Coad BR, Bulone V. A review on integrated biorefining of brown algae focusing on bioactive compounds and holistic biomass valorisation. J Ind Eng Chem. 2025. https://doi.org/10.1016/j.jiec.2025.03.047.
Carpena M, Garcia-Perez P, Garcia-Oliveira P, Chamorro F, Otero P, Lourenço-Lopes C, Cao H, Simal-Gandara J, Prieto MA. Biological properties and potential of compounds extracted from red seaweeds. Phytochem Rev Proc Phytochem Soc Europe. 2022; 1–32.
Cadar E, Popescu A, Dragan AM, Pesterau AM, Pascale C, Anuta V, et al. Bioactive compounds of marine algae and their potential health and nutraceutical applications: a review. Mar Drugs. 2025. https://doi.org/10.3390/md23040152.
Article PubMed PubMed Central Google Scholar
Besednova NN, Andryukov BG, Zaporozhets TS, Kuznetsova TA, Kryzhanovsky SP, Ermakova SP, et al. Molecular targets of brown algae phlorotannins for the therapy of inflammatory processes of various origins. Mar Drugs. 2022. https://doi.org/10.3390/md20040243.
Article PubMed PubMed Central Google Scholar
Narayanan M, Rajinikanth V. Effects of bioactive compounds from marine algae on cancer-related inflammation: a review. Medical oncology (Northwood, London, England). 2025;42:250.
Farghali M, Mohamed IMA, Osman AI, Rooney DW. Seaweed for climate mitigation, wastewater treatment, bioenergy, bioplastic, biochar, food, pharmaceuticals, and cosmetics: a review. Environ Chem Lett. 2023;21:97–152.
Article PubMed CAS Google Scholar
Mukund A, Afridi MA, Karolak A, Park MA, Permuth JB, Rasool G. Pancreatic ductal adenocarcinoma (PDAC): a review of recent advancements enabled by artificial intelligence. Cancers (Basel). 2024;16:2240.
Article PubMed CAS Google Scholar
Zayed A, El-Aasr M, Ibrahim A-RS, Ulber R. Fucoidan characterization: determination of purity and physicochemical and chemical properties. Mar Drugs. 2020;18:571.
Article PubMed PubMed Central CAS Google Scholar
Li R, Luo P, Guo Y, He Y, Wang C. Clinical features, treatment, and prognosis of SGLT2 inhibitors induced acute pancreatitis. Expert Opin Drug Saf. 2024; 1–5. https://doi.org/10.1080/14740338.2024.2396387.
Sravani ANKV, Thomas J. Targeting epithelial-mesenchymal transition signaling pathways with dietary phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers. Heliyon. 2025;11:e41964.
Article PubMed PubMed Central CAS Google Scholar
Liu HD, Ma DY, Shi SR, Song SL, Li WL, Qi XH, et al. Preparation and bioactivities of low-molecular weight fucoidans and fuco-oligosaccharides: a review. Carbohydr Polym. 2025;356:123377.
Article PubMed CAS Google Scholar
Maheswari V, Babu PAS. Phlorotannin and its derivatives, a potential antiviral molecule from brown seaweeds, an overview. Russ J Mar Biol. 2022;48:309–24.
Article PubMed PubMed Central CAS Google Scholar
Devaraji M, Thanikachalam PV. Phytoconstituents as emerging therapeutics for breast cancer: mechanistic insights and clinical implications. Cancer Pathog Ther. 2025. https://doi.org/10.1016/j.cpt.2025.02.006.
Article PubMed PubMed Central Google Scholar
Xu JW, Yan Y, Wang L, Wu D, Ye NK, Chen SH, et al. Marine bioactive compound dieckol induces apoptosis and inhibits the growth of human pancreatic cancer cells PANC-1. J Biochem Mol Toxicol. 2021;35:e22648.
Article PubMed CAS Google Scholar
Frazzini S, Rossi L. Anticancer properties of macroalgae: a comprehensive review. Mar Drugs. 2025. https://doi.org/10.3390/md23020070.
Article PubMed PubMed Central Google Scholar
Abuzahrah SS, Elbehairi SEI, Bakhsh T, Atwa A, Juaid N, Mekky RH. Marine-derived secondary metabolites in oncology: a comprehensive review. Current Research in Biotechnology. 2025;10:100300.
Usov AI, Bilan MI, Ustyuzhanina NE, Nifantiev NE. Fucoidans of brown algae: comparison of sulfated polysaccharides from Fucus vesiculosus and Ascophyllum nodosum. Mar Drugs. 2022. https://doi.org/10.3390/md20100638.
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