NPY-functionalized niosomes for targeted delivery of margatoxin in breast cancer therapy

Langley DB, et al. Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY). Neuropeptides. 2022;92:102231.

Article  PubMed  CAS  Google Scholar 

Chen Q-C, Zhang Y. The role of NPY in the regulation of bone metabolism. Front Endocrinol. 2022;13:833485.

Article  Google Scholar 

Vohra MS, et al. AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity. Eur J Pharmacol. 2022;915:174611.

Article  PubMed  CAS  Google Scholar 

Medeiros PJ, et al. Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line. Int J Cancer. 2012;131(2):276–86.

Article  PubMed  CAS  Google Scholar 

Pascetta SA, et al. Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling. BMC Cancer. 2023;23(1):494.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sigorski D, et al. Neuropeptide Y in cancer—biological functions and potential clinical implications. Cancer Metastasis Rev. 2025;44(1):21.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sánchez ML, Rodríguez FD, Coveñas R. Neuropeptide Y peptide family and cancer: antitumor therapeutic strategies. Int J Mol Sci. 2023;24(12):9962.

Article  PubMed  PubMed Central  Google Scholar 

Bhat R, et al. NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer. Sci Rep. 2022;12(1):1972.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin S-T, et al. Update on the role of neuropeptide Y and other related factors in breast cancer and osteoporosis. Front Endocrinol. 2021;12:705499.

Article  Google Scholar 

Fonseca IC, et al. PET imaging of the neuropeptide Y system: a systematic review. Molecules. 2022;27(12):3726.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sun W, et al. Serum neuropeptide Y: a potential prognostic marker of intracerebral hemorrhage. Dis Markers. 2021;2021(1):7957013.

PubMed  PubMed Central  Google Scholar 

Liu J, et al. The novel methylation biomarker NPY5R sensitizes breast cancer cells to chemotherapy. Front Cell Dev Biol. 2022;9:798221.

Article  PubMed  PubMed Central  Google Scholar 

Sheriff S, et al. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. Mol Cancer Res. 2010;8(4):604–14.

Article  PubMed  CAS  Google Scholar 

Chakroborty D, et al. Neuropeptide Y, a paracrine factor secreted by cancer cells, is an independent regulator of angiogenesis in colon cancer. Br J Cancer. 2022;127(8):1440–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dawoud MM, et al. Clinical significance of immunohistochemical expression of neuropeptide Y1 receptor in patients with breast cancer in Egypt. Appl Immunohistochem Mol Morphol. 2021;29(4):277–86.

Article  PubMed  CAS  Google Scholar 

Szabo BC, et al. Novel insights into the modulation of the voltage-gated potassium channel KV1. 3 activation gating by membrane ceramides. J Lipid Res. 2024;65(8):100596.

Article  PubMed  PubMed Central  Google Scholar 

Zúñiga L, et al. Potassium channels as a target for cancer therapy: current perspectives. Onco Targets Ther. 2022;15:783.

Article  PubMed  PubMed Central  Google Scholar 

Szabó I, et al. Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A. 2008;105(39):14861–6.

Article  PubMed  PubMed Central  Google Scholar 

Ionov Y, et al. Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. Proc Natl Acad Sci U S A. 2000;97(20):10872–7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bartok A, et al. Margatoxin is a non-selective inhibitor of human Kv1. 3 K+ channels. Toxicon. 2014;87:6–16.

Article  PubMed  CAS  Google Scholar 

Szabò I, et al. Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax-and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis. Cell Death Differ. 2011;18(3):427–38.

Article  PubMed  Google Scholar 

Erdogan A, et al. Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells. J Vasc Res. 2005;42(5):368–76.

Article  PubMed  CAS  Google Scholar 

Wu BM, et al. Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling. Int J Mol Med. 2020;45(1):103–14.

PubMed  CAS  Google Scholar 

Ge X, et al. Advances of non-ionic surfactant vesicles (niosomes) and their application in drug delivery. Pharmaceutics. 2019;11(2):55.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bartelds R, et al. Niosomes, an alternative for liposomal delivery. PLoS ONE. 2018;13(4):e0194179.

Article  PubMed  PubMed Central  Google Scholar 

Amoabediny G, et al. Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: a comprehensive review. Int J Polym Mater Polym Biomater. 2018;67(6):383–400.

Article  CAS  Google Scholar 

Haseli S, et al. A novel pH-responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan-based nanocarrier: emphasis on the concurrent improvement of loading, sustained release, and apoptosis induction. Biotechnol Prog. 2022;38(5):e3280.

Article  PubMed  CAS  Google Scholar 

Gharbavi M, et al. In vivo and in vitro biocompatibility study of novel microemulsion hybridized with bovine serum albumin as nanocarrier for drug delivery. Heliyon. 2019. https://doi.org/10.1016/j.heliyon.2019.e01858.

Article  PubMed  PubMed Central  Google Scholar 

Witika BA, et al. Current advances in specialised niosomal drug delivery: manufacture, characterization and drug delivery applications. Int J Mol Sci. 2022;23(17):9668.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ruwizhi N, Aderibigbe BA. The efficacy of cholesterol-based carriers in drug delivery. Molecules. 2020;25(18):4330.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Moammeri A, et al. Current advances in niosomes applications for drug delivery and cancer treatment. Mater Today Bio. 2023. https://doi.org/10.1016/j.mtbio.2023.100837.

Article  PubMed  PubMed Central  Google Scholar 

Haider AJ, Al-Kinani MA, Al-Musawi S. Preparation and characterization of gold coated super paramagnetic iron nanoparticle using pulsed laser ablation in liquid method. Key Eng Mater. 2021;886:77–85.

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