Yu C, Li L, Wang S, Xu Y, Wang L, Huang Y, et al. Advances in nanomaterials for the diagnosis and treatment of head and neck cancers: a review. Bioact Mater. 2023;25:430–44.
Lederman M, et al. Megavoltage advances vs the orthovoltage era. JAMA. 1972;220(3):398–400.
Article CAS PubMed Google Scholar
Schulz A, Meyer F, Dubrovska A, Borgmann K. Cancer stem cells and radioresistance: DNA repair and beyond. Cancers (Basel). 2019. https://doi.org/10.3390/cancers11060862.
Article PubMed PubMed Central Google Scholar
Göttgens EL, Ostheimer C, Span PN, Bussink J, Hammond EM, et al. HPV, hypoxia and radiation response in head and neck cancer. Br J Radiol. 2019;92(1093):20180047.
Good JS, Harrington KJ. The hallmarks of cancer and the radiation oncologist: updating the 5Rs of radiobiology. Clin Oncol (R Coll Radiol). 2013;25(10):569–77.
Article CAS PubMed Google Scholar
Kavousi Y, Mohammadi M, Ahmadikamalabadi M, Koosha F, et al. Gold nanoparticles in radiation therapy: an old story yet mesmerizing. Iran J Blood Cancer. 2022;14:140–9.
Gong L, Zhang Y, Liu C, Zhang M, Han S. Application of radiosensitizers in cancer radiotherapy. Int J Nanomed. 2021;16:1083–102.
Akbari A, Shokati Eshkiki Z, Mayahi S, Amini SM. In-vitro investigation of curcumin coated gold nanoparticles effect on human colorectal adenocarcinoma cell line. Nanomed Res J. 2022;7(1):66–72.
Zhu X, Chen Z, Li X, et al. Diosgenin inhibits the proliferation, migration and invasion of the optic nerve sheath meningioma cells via induction of mitochondrial-mediated apoptosis, autophagy and G0/G1 cell cycle arrest. J BU ON. 2020;25(1):508–13.
Raju J, Bird RP, et al. Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Lett. 2007;255(2):194–204.
Article CAS PubMed Google Scholar
Khathayer F, Ray SK, et al. Diosgenin as a novel alternative therapy for inhibition of growth, invasion, and angiogenesis abilities of different glioblastoma cell lines. Neurochem Res. 2020;45(10):2336–51.
Article CAS PubMed Google Scholar
Guo W, Chen Y, Gao J, Zhong K, Wei H, Li K, et al. Diosgenin exhibits tumor suppressive function via down-regulation of EZH2 in pancreatic cancer cells. Cell Cycle. 2019;18(15):1745–58.
Article CAS PubMed PubMed Central Google Scholar
Chen PS, Shih YW, Huang HC, Cheng HW. Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. PLoS ONE. 2011;6(5): e20164.
Article CAS PubMed PubMed Central Google Scholar
Yazdanparast S, Bashash D, Nikkhah Bahrami A, Ghorbani M, Izadirad M, Bakhtiyaridovvombaygi M, et al. Royal jelly induces ROS-mediated apoptosis in acute lymphoblastic leukemia (ALL)-derived Nalm-6 cells: shedding light on novel therapeutic approaches for ALL. Iran J Basic Med Sci. 2024;27(7):801–12.
PubMed PubMed Central Google Scholar
Wang W, Chen Z, Chen X, Ni S, Jia Y, Fan L, et al. DG-8d, a novel diosgenin derivative, decreases the proliferation and induces the apoptosis of A549 cells by inhibiting the PI3k/Akt signaling pathway. Steroids. 2021;174:108898.
Article CAS PubMed Google Scholar
Mao XM, Zhou P, Li SY, Zhang XY, Shen JX, Chen QX, et al. Diosgenin suppresses cholangiocarcinoma cells via inducing cell cycle arrest and mitochondria-mediated apoptosis. Onco Targets Ther. 2019;12:9093–104.
Article CAS PubMed PubMed Central Google Scholar
Dong J, Li Y, Xiao H, Luo D, Zhang S, Zhu C, et al. Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2. Toxicol Appl Pharmacol. 2019;364:12–21.
Article CAS PubMed Google Scholar
Liu X, Sun C, Jin X, Li P, Ye F, Zhao T, et al. Genistein enhances the radiosensitivity of breast cancer cells via G₂/M cell cycle arrest and apoptosis. Molecules. 2013;18(11):13200–17.
Article CAS PubMed PubMed Central Google Scholar
Fabbrizi MR, Parsons JL. Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation. Expert Rev Mol Med. 2022;24:e2.
Article CAS PubMed Central Google Scholar
Ren QL, Wang Q, Zhang XQ, Wang M, Hu H, Tang JJ, et al. Anticancer activity of diosgenin and its molecular mechanism. Chin J Integr Med. 2023;29(8):738–49.
Article CAS PubMed Google Scholar
Liu Y, Zhou Z, Yan J, Wu X, Xu G, et al. Diosgenin exerts antitumor activity via downregulation of Skp2 in breast cancer cells. Biomed Res Int. 2020;2020:8072639.
Article PubMed PubMed Central Google Scholar
Sikka S, Shanmugam MK, Siveen KS, Ong TH, Yang MH, Lee JH, et al. Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-κB/STAT3 signaling cascades. Eur J Pharmacol. 2021;906:174274.
Article CAS PubMed Google Scholar
Kim DS, Jeon BK, Lee YE, Woo WH, Mun YJ, et al. Diosgenin induces apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway. Evid Based Complement Altern Med. 2012;2012:981675.
Liao J, Jin H, Li S, Xu L, Peng Z, Wei G, et al. Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38(1):454.
Article PubMed PubMed Central Google Scholar
Salakou S, Kardamakis D, Tsamandas AC, Zolota V, Apostolakis E, Tzelepi V, et al. Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis. In Vivo. 2007;21(1):123–32.
Leger DY, Liagre B, Corbière C, Cook-Moreau J, Beneytout JL, et al. Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression. Int J Oncol. 2004;25(3):555–62.
Li Y, Wang X, Cheng S, Du J, Deng Z, Zhang Y, et al. Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. Oncol Rep. 2015;33(2):693–8.
Article CAS PubMed Google Scholar
Zha L, Qiao T, Yuan S, Lei L. Enhancement of radiosensitivity by CpG-oligodeoxyribonucleotide-7909 in human non-small cell lung cancer A549 cells. Cancer Biother Radiopharm. 2010;25(2):165–70.
Wang Y, Yang L, Zhang J, Zhou M, Shen L, Deng W, et al. Radiosensitization by irinotecan is attributed to G2/M phase arrest, followed by enhanced apoptosis, probably through the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal cancer cells. Int J Oncol. 2018;53(4):1667–80.
Sur S, Agrawal DK. Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategies. Mol Cell Biochem. 2016;416(1–2):33–46.
Article CAS PubMed PubMed Central Google Scholar
Ahmadi Kamalabadi M, Ostadebrahimi H, Koosha F, Fatemidokht A, Menbari Oskuie I, Amin F, et al. Gd-GQDs as nanotheranostic platform for the treatment of HPV-positive oropharyngeal cancer. Med Oncol. 2024;41(8):205.
Article CAS PubMed Google Scholar
Bartek J, Lukas J, et al. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 2003;3(5):421–9.
Article CAS PubMed Google Scholar
Sun M, Pan D, Chen Y, Li Y, Gao K, Hu B, et al. Coroglaucigenin enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway. Oncotarget. 2017;8(20):32807–20.
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