Siddiqui F, Vaqar S, Siddiqui AH Lung Cancer, in StatPearls. 2023: Treasure Island (FL).

Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 2011;32(4):605–44.

Article  PubMed  Google Scholar 

Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359(13):1367–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnes TA, Amir E. HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer. Br J Cancer. 2017;117(4):451–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006;6(1):24–37.

Article  PubMed  Google Scholar 

Raskov H, Orhan A, Christensen JP, Gogenur I. Cytotoxic CD8(+) T cells in cancer and cancer immunotherapy. Br J Cancer. 2021;124(2):359–67.

Article  CAS  PubMed  Google Scholar 

Marvel D, Gabrilovich DI. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J Clin Invest. 2015;125(9):3356–64.

Article  PubMed  PubMed Central  Google Scholar 

Togashi Y, Shitara K, Nishikawa H. Regulatory T cells in cancer immunosuppression - implications for anticancer therapy. Nat Rev Clin Oncol. 2019;16(6):356–71.

Article  CAS  PubMed  Google Scholar 

Ilie M, Hofman V, Ortholan C, Bonnetaud C, Coelle C, Mouroux J, et al. Predictive clinical outcome of the intratumoral CD66b-positive neutrophil-to-CD8-positive T-cell ratio in patients with resectable nonsmall cell lung cancer. Cancer. 2012;118(6):1726–37.

Article  CAS  PubMed  Google Scholar 

Singhal S, Bhojnagarwala PS, O’Brien S, Moon EK, Garfall AL, Rao AS, et al. Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer. Cancer Cell. 2016;30(1):120–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, et al. Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest. 2014;124(12):5466–80.

Article  PubMed  PubMed Central  Google Scholar 

Sionov RV, Fridlender ZG, Granot Z. The multifaceted roles neutrophils play in the tumor microenvironment. Cancer Microenviron. 2015;8(3):125–58.

Article  CAS  PubMed  Google Scholar 

Granot Z. Neutrophils as a therapeutic target in cancer. Front Immunol. 2019;10:1710.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carus A, Ladekarl M, Hager H, Pilegaard H, Nielsen PS, Donskov F. Tumor-associated neutrophils and macrophages in non-small cell lung cancer: no immediate impact on patient outcome. Lung Cancer. 2013;81(1):130–7.

Article  PubMed  Google Scholar 

Salcher S, Sturm G, Horvath L, Untergasser G, Kuempers C, Fotakis G, et al. High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer. Cancer Cell. 2022;40(12):1503–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faget J, Peters S, Quantin X, Meylan E, Bonnefoy N. Neutrophils in the era of immune checkpoint blockade. J Immunother Cancer. 2021. https://doi.org/10.1136/jitc-2020-002242.

Article  PubMed  PubMed Central  Google Scholar 

Kaltenmeier C, Yazdani HO, Morder K, Geller DA, Simmons RL, Tohme S. Neutrophil extracellular traps promote T cell exhaustion in the tumor microenvironment. Front Immunol. 2021;12:785222.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ocana A, Nieto-Jimenez C, Pandiella A, Templeton AJ. Neutrophils in cancer: prognostic role and therapeutic strategies. Mol Cancer. 2017;16(1):137.

Article  PubMed  PubMed Central  Google Scholar 

De Meo ML, Spicer JD. The role of neutrophil extracellular traps in cancer progression and metastasis. Semin Immunol. 2021;57:101595.

Article  PubMed  Google Scholar 

Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, et al. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature. 2020;583(7814):133–8.

Article  CAS  PubMed  Google Scholar 

Kouser L, Madhukaran SP, Shastri A, Saraon A, Ferluga J, Al-Mozaini M, et al. Emerging and novel functions of complement protein C1q. Front Immunol. 2015;6:317.

Article  PubMed Central  Google Scholar 

Reid KB, Porter RR. Subunit composition and structure of subcomponent C1q of the first component of human complement. Biochem J. 1976;155(1):19–23.

Article  CAS  PubMed  Google Scholar 

Bulla R, Tripodo C, Rami D, Ling GS, Agostinis C, Guarnotta C, et al. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. Nat Commun. 2016;7:10346.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reese B, Silwal A, Daugherity E, Daugherity M, Arabi M, Daly P, et al. Complement as prognostic biomarker and potential therapeutic target in renal cell carcinoma. J Immunol. 2020;205(11):3218–29.

Article  CAS  PubMed  Google Scholar 

Doran AC, Yurdagul A Jr, Tabas I. Efferocytosis in health and disease. Nat Rev Immunol. 2020;20(4):254–67.

Article  CAS  PubMed  Google Scholar 

Ramos C, Oehler R. Clearance of apoptotic cells by neutrophils in inflammation and cancer. Cell Death Discov. 2024;10(1):26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galvan MD, Greenlee-Wacker MC, Bohlson SS. C1q and phagocytosis: the perfect complement to a good meal. J Leukoc Biol. 2012;92(3):489–97.

Article  CAS  Google Scholar 

Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, et al. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J Immunol. 2010;185(4):2044–50.

Article  CAS  PubMed  Google Scholar 

Tajbakhsh A, Gheibi Hayat SM, Movahedpour A, Savardashtaki A, Loveless R, Barreto GE, et al. The complex roles of efferocytosis in cancer development, metastasis, and treatment. Biomed Pharmacother. 2021;140:111776.

Article  CAS  PubMed  Google Scholar 

Vaught DB, Stanford JC, Cook RS. Efferocytosis creates a tumor microenvironment supportive of tumor survival and metastasis. Cancer Cell Microenviron. 2015. https://doi.org/10.14800/ccm.666.

Article  PubMed  PubMed Central  Google Scholar 

Schimek V, Strasser K, Beer A, Gober S, Walterskirchen N, Brostjan C, et al. Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment. Cell Death Dis. 2022;13(2):113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Esmann L, Idel C, Sarkar A, Hellberg L, Behnen M, Moller S, et al. Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells. J Immunol. 2010;184(1):391–400.