Li S, Young KH, Medeiros LJ. Diffuse large B-cell lymphoma. Pathology. 2018;50:74–87.
Galaznik A, Huelin R, Stokes M, Guo Y, Hoog M, Bhagnani T, et al. Systematic review of therapy used in relapsed or refractory diffuse large B-cell lymphoma and follicular lymphoma. Future Sci OA. 2018;4:FSO322.
Article CAS PubMed PubMed Central Google Scholar
Sehn LH, Gascoyne RD. Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity. Blood. 2015;125:22–32.
Article CAS PubMed Google Scholar
Ennishi D, Hsi ED, Steidl C, Scott DW. Toward a new molecular taxonomy of diffuse large B-cell lymphoma. Cancer Discov. 2020;10:1267–81.
Article CAS PubMed Google Scholar
Young RM, Shaffer AL 3rd, Phelan JD, Staudt LM. B-cell receptor signaling in diffuse large B-cell lymphoma. Semin Hematol. 2015;52:77–85.
Article CAS PubMed PubMed Central Google Scholar
Battistello E, Katanayeva N, Dheilly E, Tavernari D, Donaldson MC, Bonsignore L, et al. Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma. Blood. 2018;131:2345–56.
Article CAS PubMed PubMed Central Google Scholar
Takeyasu Y, Satake A, Azuma Y, Tsubokura Y, Yoshimura H, Hotta M, et al. Tyrosine kinase inhibitor and rituximab-CHOP treatment for concurrent chronic myeloid leukemia and non-Hodgkin lymphoma: a case report. Clin Case Rep. 2017;5:2047–50.
Article PubMed PubMed Central Google Scholar
Nguyen PH, Fedorchenko O, Rosen N, Koch M, Barthel R, Winarski T, et al. Lyn kinase in the tumor microenvironment is essential for the progression of chronic lymphocytic leukemia. Cancer Cell. 2016;30:610–22.
Article CAS PubMed Google Scholar
Ingley E. Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal. 2012;10:21.
Article CAS PubMed PubMed Central Google Scholar
Sun Y, Yang Y, Zhao Y, Li X, Zhang Y, Liu Z. The role of the tyrosine kinase Lyn in allergy and cancer. Mol Immunol. 2021;131:121–6.
Article CAS PubMed Google Scholar
Brian BFt, Freedman TS. The src-family kinase Lyn in immunoreceptor signaling. Endocrinology. 2021;162:bqab152. https://doi.org/10.1210/endocr/bqab152.
Article PubMed PubMed Central Google Scholar
Harder KW, Parsons LM, Armes J, Evans N, Kountouri N, Clark R, et al. Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity. 2001;15:603–15.
Article CAS PubMed Google Scholar
Hibbs ML, Harder KW, Armes J, Kountouri N, Quilici C, Casagranda F, et al. Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med. 2002;196:1593–604.
Article CAS PubMed PubMed Central Google Scholar
Tauzin S, Ding H, Khatib K, Ahmad I, Burdevet D, van Echten-Deckert G, et al. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood. 2008;111:2310–20.
Article CAS PubMed Google Scholar
Tibaldi E, Pagano MA, Frezzato F, Trimarco V, Facco M, Zagotto G, et al. Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells. Haematologica. 2017;102:1401–12.
Article CAS PubMed PubMed Central Google Scholar
Westermarck J, Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med. 2008;14:152–60.
Article CAS PubMed Google Scholar
Li M, Makkinje A, Damuni Z. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J Biol Chem. 1996;271:11059–62.
Article CAS PubMed Google Scholar
Christensen DJ, Chen Y, Oddo J, Matta KM, Neil J, Davis ED, et al. SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. Blood. 2011;118:4150–8.
Article CAS PubMed PubMed Central Google Scholar
Switzer CH, Cheng RY, Vitek TM, Christensen DJ, Wink DA, Vitek MP. Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. Oncogene. 2011;30:2504–13.
Article CAS PubMed PubMed Central Google Scholar
Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, et al. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood. 2008;111:275–84.
Article CAS PubMed PubMed Central Google Scholar
Hung MH, Chen YL, Chu PY, Shih CT, Yu HC, Tai WT, et al. Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential. Oncogene. 2016;35:4891–902.
Article CAS PubMed Google Scholar
Schneider CA, Rasband WS, Eliceiri KW. NIH image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9:671–5.
Article CAS PubMed PubMed Central Google Scholar
Liu CY, Hsieh FS, Chu PY, Tsai WC, Huang CT, Yu YB, et al. Carfilzomib induces leukaemia cell apoptosis via inhibiting ELK1/KIAA1524 (Elk-1/CIP2A) and activating PP2A not related to proteasome inhibition. Br J Haematol. 2017;177:726–40.
Article CAS PubMed Google Scholar
Chen JL, Chu PY, Huang CT, Huang TT, Wang WL, Lee YH, et al. Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma. Mol Med. 2022;28:93.
Article CAS PubMed PubMed Central Google Scholar
Huang TT, Tseng LM, Chen JL, Chu PY, Lee CH, Huang CT, et al. Kynurenine 3-monooxygenase upregulates pluripotent genes through beta-catenin and promotes triple-negative breast cancer progression. EBioMedicine. 2020;54:102717.
Article PubMed PubMed Central Google Scholar
Ruiz-Vela A, Aggarwal M, de la Cueva P, Treda C, Herreros B, Martin-Perez D, et al. Lentiviral (HIV)-based RNA interference screen in human B-cell receptor regulatory networks reveals MCL1-induced oncogenic pathways. Blood. 2008;111:1665–76.
Article CAS PubMed Google Scholar
Lenz G, Wright GW, Emre NC, Kohlhammer H, Dave SS, Davis RE, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A. 2008;105:13520–5.
Article CAS PubMed PubMed Central Google Scholar
Colaprico A, Silva TC, Olsen C, Garofano L, Cava C, Garolini D, et al. TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res. 2016;44:e71.
Comments (0)