Coronary microvascular dysfunction is a determinant of perfusion–contraction matching during ischemia

Canty JM, Giglia J, Kandath D (1990) Effect of tachycardia on regional function and transmural myocardial perfusion during graded coronary pressure reduction in conscious dogs. Circulation 82:1815–1825

Article  PubMed  Google Scholar 

Canty JM Jr. (1988) Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog. Circ Res 63:821–836

Article  PubMed  Google Scholar 

Canty JM Jr., Smith TP Jr. (1995) Adenosine-recruitable flow reserve is absent during myocardial ischemia in unanesthetized dogs studied in the basal state. Circ Res 76:1079–1087

Article  PubMed  Google Scholar 

Canty JM Jr., Smith TP Jr. (1995) Modulation of coronary autoregulatory responses by endothelium-derived nitric oxide. Int J Cardiol 50:207–215

Article  PubMed  Google Scholar 

Canty JM, Klocke FJ (1985) Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve. Circulation 71:370–377

Article  PubMed  Google Scholar 

Cho YK, Merkle H, Zhang J, Tsekos NV, Bache RJ, Ugurbil K (2001) Noninvasive measurements of transmural myocardial metabolites using 3-D 31P NMR spectroscopy. Am J Physiol Heart Circ Physiol 280:H489–H497

Article  CAS  PubMed  Google Scholar 

Duncker DJ, Bache RJ (1994) Inhibition of nitric oxide production aggravates myocardial hypoperfusion during exercise in the presence of a coronary artery stenosis. Circ Res 74:629–640

Article  CAS  PubMed  Google Scholar 

Essajee SI, Dick GM, Tucker SM, Warne CM, Figueroa CA, Beard DA, Duncker DJ, Tune JD (2025) Impairment of local metabolic coronary control involves perfusion-contraction matching not supply–demand imbalance. Basic Res Cardiol. https://doi.org/10.1007/s00395-025-01148-3

Article  PubMed  Google Scholar 

Fallavollita JA, Malm BJ, Canty JM (2003) Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest. Circ Res 92:48–55. https://doi.org/10.1161/01.res.0000049104.57549.03

Article  CAS  PubMed  Google Scholar 

Galassi AR, Crea F, Araujo MI, Lammertsma AA, Pupita G, Yamamoto Y, Rechavia E, Jones T, Kaski JC, Maseri A (1993) Comparison of regional myocardial blood flow in syndrome X and one-vessel coronary artery disease. Am J Cardiol 72:134–139

Article  CAS  PubMed  Google Scholar 

Gallagher KP, Matsuzaki M, Koziol JA, Kemper WS, Ross J Jr. (1984) Regional myocardial perfusion and wall thickening during ischemia in conscious dogs. Am J Physiol 247:H727–H738

CAS  PubMed  Google Scholar 

Gioia GD, Melin JA, Bruyne BD (2020) Coronary autoregulatory plateau in humans. JACC 76:1270–1271. https://doi.org/10.1016/j.jacc.2020.06.074

Article  PubMed  Google Scholar 

Gladwin MT, Crawford JH, Patel RP (2004) The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. Free Radic Biol Med 36:707–717. https://doi.org/10.1016/j.freeradbiomed.2003.11.032

Article  CAS  PubMed  Google Scholar 

Gregg DE (1963) Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circ Res 13:497–500. https://doi.org/10.1161/01.RES.13.6.497

Article  CAS  PubMed  Google Scholar 

Heusch G (2019) Myocardial ischemia: lack of coronary blood flow, myocardial oxygen supply-demand imbalance, or what? Am J Physiol Heart Circ Physiol 316:H1439–H1446. https://doi.org/10.1152/ajpheart.00139.2019

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heusch G (2021) Myocardial stunning and hibernation revisited. Nat Rev Cardiol 18:522–536. https://doi.org/10.1038/s41569-021-00506-7

Article  PubMed  Google Scholar 

Mahendiran T, Collet C, de Bruyne B (2024) Coronary-artery autoregulation with increasing stenosis. N Engl J Med 390:2030–2032. https://doi.org/10.1056/NEJMc2402216

Article  PubMed  Google Scholar 

Ostergaard L, Kristiansen SB, Angleys H, Frøkiær J, Michael Hasenkam J, Jespersen SN, Bøtker HE (2014) The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease. Basic Res Cardiol 109:409. https://doi.org/10.1007/s00395-014-0409-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pantely GA, Malone SA, Rhen WS, Anselone CG, Arai A, Bristow J, Bristow JD (1990) Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res 67:1481–1493

Article  CAS  PubMed  Google Scholar 

Ross J Jr (1991) Myocardial perfusion-contraction matching: implications for coronary heart disease and hibernation. Circulation 83:1076–1083

Article  PubMed  Google Scholar 

Schulz R, Guth BD, Pieper K, Martin C, Heusch G (1992) Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery. A model of short-term hibernation. Circ Res 70:1282–1295. https://doi.org/10.1161/01.res.70.6.1282

Article  CAS  PubMed  Google Scholar 

Traverse JH, Melchert P, Pierpont GL, Jones B, Crampton M, Bache RJ (1999) Regulation of myocardial blood flow by oxygen consumption is maintained in the failing heart during exercise. Circ Res 84:401–408

Article  CAS  PubMed  Google Scholar 

Weiss HR, Neubauer JA, Lipp JA, Sinha AK (1978) Quantitative determination of regional oxygen consumption in the dog heart. Circ Res 42:394–401

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif