Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263. https://doi.org/10.3322/caac.21834
Bengtsson A, Andersson R, Ansari D (2020) The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data. Sci Rep 10(1):16425. https://doi.org/10.1038/s41598-020-73525-y
Article PubMed PubMed Central CAS Google Scholar
Li K, Luo H, Huang L et al (2020) Microsatellite instability: a review of what the oncologist should know. Cancer Cell Int 20:16. https://doi.org/10.1186/s12935-019-1091-8
Article PubMed PubMed Central Google Scholar
Fuchs CS, Doi T, Jang RW et al (2018) Safety and efficacy of Pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 trial. JAMA Oncol 4(5):e180013. https://doi.org/10.1001/jamaoncol.2018.0013
Article PubMed PubMed Central Google Scholar
André T, Shiu KK, Kim TW et al (2020) Pembrolizumab in microsatellite-instability-high advanced colorectal cancer. N Engl J Med 383(23):2207–2218. https://doi.org/10.1056/NEJMoa2017699
Puliga E, Corso S, Pietrantonio F et al (2021) Microsatellite instability in Gastric cancer: between lights and shadows. Cancer Treat Rev 95:102175. https://doi.org/10.1016/j.ctrv.2021.102175
Zugasti I, Espinosa-Aroca L, Fidyt K et al (2025) Car-T cell therapy for cancer: current challenges and future directions. Signal Transduct Target Ther 10(1):210. https://doi.org/10.1038/s41392-025-02269-w
Article PubMed PubMed Central Google Scholar
Chen T, Wang M, Chen Y et al (2024) Current challenges and therapeutic advances of Car-T cell therapy for solid tumors. Cancer Cell Int 24(1):133. https://doi.org/10.1186/s12935-024-03315-3
Article PubMed PubMed Central CAS Google Scholar
Chohan KL, Siegler EL, Kenderian SS (2023) Car-T cell therapy: the efficacy and toxicity balance. Curr Hematol Malig Rep 18(2):9–18. https://doi.org/10.1007/s11899-023-00687-7
Article PubMed PubMed Central Google Scholar
Huntington ND, Cursons J, Rautela J (2020) The cancer-natural killer cell immunity cycle. Nat Rev Cancer 20(8):437–454. https://doi.org/10.1038/s41568-020-0272-z
Article PubMed CAS Google Scholar
Ruggeri L, Capanni M, Urbani E et al (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295(5562):2097–2100. https://doi.org/10.1126/science.1068440
Article PubMed CAS Google Scholar
Miller JS, Soignier Y, Panoskaltsis-Mortari A et al (2005) Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 105(8):3051–3057. https://doi.org/10.1182/blood-2004-07-2974
Article PubMed CAS Google Scholar
Rubnitz JE, Inaba H, Ribeiro RC et al (2010) NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol 28(6):955–959. https://doi.org/10.1200/JCO.2009.24.4590
Article PubMed PubMed Central CAS Google Scholar
Li B, Zhu X, Ge J et al (2025) Intraperitoneal infusion of NKG2D CAR-NK cells induces endogenous CD8(+) T cell activation in patients with advanced colorectal cancer. Mol Ther 33(9):4509–4528. https://doi.org/10.1016/j.ymthe.2025.05.026
Article PubMed CAS Google Scholar
Nieto Y, Banerjee P, Kaur I et al (2025) Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial. Nat Med 31(6):1987–1993. https://doi.org/10.1038/s41591-025-03640-8
Article PubMed CAS Google Scholar
Marin D, Li Y, Basar R et al (2024) Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19(+) B cell tumors: a phase 1/2 trial. Nat Med 30(3):772–784. https://doi.org/10.1038/s41591-023-02785-8
Article PubMed PubMed Central CAS Google Scholar
Romee R, Rosario M, Berrien-Elliott MM et al (2016) Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med 8(357):357ra123. https://doi.org/10.1126/scitranslmed.aaf2341
Article PubMed PubMed Central CAS Google Scholar
Shapiro RM, Birch GC, Hu G et al (2022) Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse. J Clin Invest. https://doi.org/10.1172/JCI154334
Article PubMed PubMed Central Google Scholar
Shapiro RM, Sheffer M, Booker MA et al (2025) First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer. J Hematol Oncol 18(1):17. https://doi.org/10.1186/s13045-025-01669-3
Article PubMed PubMed Central CAS Google Scholar
Berrien-Elliott MM, Foltz JA, Russler-Germain DA et al (2022) Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia. Sci Transl Med 14(633):eabm1375. https://doi.org/10.1126/scitranslmed.abm1375
Article PubMed PubMed Central CAS Google Scholar
El-Khoueiry A, Saavedra O, Thomas J et al (2025) First-in-human phase I study of a CD16A bispecific innate cell engager, AFM24, targeting EGFR-expressing solid tumors. Clin Cancer Res 31(7):1257–1267. https://doi.org/10.1158/1078-0432.CCR-24-1991
Article PubMed PubMed Central CAS Google Scholar
Pende D, Parolini S, Pessino A et al (1999) Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J Exp Med 190(10):1505–1516. https://doi.org/10.1084/jem.190.10.1505
Article PubMed PubMed Central CAS Google Scholar
Sen Santara S, Lee DJ, Crespo  et al (2023) The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. Nature 616(7956):348–356. https://doi.org/10.1038/s41586-023-05912-0
Article PubMed CAS Google Scholar
Koch J, Steinle A, Watzl C et al (2013) Activating natural cytotoxicity receptors of natural killer cells in cancer and infection. Trends Immunol 34(4):182–191. https://doi.org/10.1016/j.it.2013.01.003
Article PubMed CAS Google Scholar
Chen S, Zhu H, Jounaidi Y (2024) Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization. Signal Transduct Target Ther 9(1):302. https://doi.org/10.1038/s41392-024-02005-w
Article PubMed PubMed Central CAS Google Scholar
Anderson P, Caligiuri M, O’Brien C et al (1990) Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells. Proc Natl Acad Sci U S A 87(6):2274–2278. https://doi.org/10.1073/pnas.87.6.2274
Article PubMed PubMed Central CAS Google Scholar
Platonova S, Cherfils-Vicini J, Damotte D et al (2011) Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma. Cancer Res 71(16):5412–5422. https://doi.org/10.1158/0008-5472.CAN-10-4179
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