Vernieri C, Fucà G, Ligorio F, Huber V, Vingiani A, Iannelli F, et al. Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer. Cancer Discov. 2022;12:90–107.

Article  CAS  PubMed  Google Scholar 

Ligorio F, Vingiani A, Torelli T, Sposetti C, Drufuca L, Iannelli F, et al. Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients. Cell Metab. 2025;37:330–344.e7.

Article  CAS  PubMed  Google Scholar 

de Groot S, Lugtenberg RT, Cohen D, Welters MJP, Ehsan I, Vreeswijk MPG, et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized Phase 2 DIRECT trial. Nat Commun. 2020;11:3083.

Article  PubMed  PubMed Central  Google Scholar 

Blaževitš O, Di Tano M, Longo VD. Fasting and fasting mimicking diets in cancer prevention and therapy. Trends Cancer. 2023;9:212–22.

Article  PubMed  Google Scholar 

Gonzalez CA, Riboli E. Diet and cancer prevention: where we are, where we are going. Nutr Cancer. 2006;56:225–31.

Article  PubMed  Google Scholar 

Kumar A, Chinnathambi S, Kumar M, Pandian GN. Food Intake and Colorectal Cancer. Nutr Cancer. 2023;75:1710–42.

Article  CAS  PubMed  Google Scholar 

Schmid A, Mathies V, Buentzel J, Keinki C, Huebner J. Diet Changes and Underlying Motives in Cancer Patients. Nutr Cancer. 2022;74:2017–28.

Article  CAS  PubMed  Google Scholar 

Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, et al. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun. 2024;15:1309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong Z, Zhang H, Nan K, Zhong J, Wu Q, Lu L, et al. Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells. Cancer Res. 2023;83:3529–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nan K, Zhong Z, Yue Y, Shen Y, Zhang H, Wang Z, et al. Fasting-mimicking diet-enriched Bifidobacterium pseudolongum suppresses colorectal cancer by inducing memory CD8(+) T cells. Gut. 2025;74:775–86.

Article  CAS  PubMed  Google Scholar 

Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, et al. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 2016;30:136–46.

Article  PubMed  PubMed Central  Google Scholar 

Chen W, Zhou M, Guan B, Xie B, Liu Y, He J, et al. Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis. Clin Transl Med. 2024;14:e1591.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gan S, Macalinao DG, Shahoei SH, Tian L, Jin X, Basnet H, et al. Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain. Cancer Cell. 2024;42:1693–1712.e24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun P, Wang H, He Z, Chen X, Wu Q, Chen W, et al. Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages. Oncotarget. 2017;8:74649–60.

Article  PubMed  PubMed Central  Google Scholar 

Wang L, Wang YJ, Wang R, Gong FL, Shi YH, Li SN, et al. Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent. J Transl Med. 2023;21:754.

Article  PubMed  PubMed Central  Google Scholar 

Cassetta L, Pollard JW. A timeline of tumour-associated macrophage biology. Nat Rev Cancer. 2023;23:238–57.

Article  CAS  PubMed  Google Scholar 

Chen Y, Song Y, Du W, Gong L, Chang H, Zou Z. Tumor-associated macrophages: an accomplice in solid tumor progression. J Biomed Sci. 2019;26:78.

Article  PubMed  PubMed Central  Google Scholar 

Lei A, Yu H, Lu S, Lu H, Ding X, Tan T, et al. A second-generation M1-polarized CAR macrophage with antitumor efficacy. Nat Immunol. 2024;25:102–16.

Article  CAS  PubMed  Google Scholar 

Xu M, Hu Y, Wu J, Liu J, Pu K. Sonodynamic Nano-LYTACs Reverse Tumor Immunosuppressive Microenvironment for Cancer Immunotherapy. J Am Chem Soc. 2024;146:34669–80.

Article  CAS  PubMed  Google Scholar 

Han S, Bao X, Zou Y, Wang L, Li Y, Yang L, et al. d-lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma. Sci Adv. 2023;9:eadg2697.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elewaut A, Estivill G, Bayerl F, Castillon L, Novatchkova M, Pottendorfer E, et al. Cancer cells impair monocyte-mediated T cell stimulation to evade immunity. Nature. 2025;637:716–25.

Article  CAS  PubMed  Google Scholar 

Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. 2014;20:1301–9.

Article  CAS  PubMed  Google Scholar 

Borden EC. Interferons α and β in cancer: therapeutic opportunities from new insights. Nat Rev Drug Discov. 2019;18:219–34.

Article  CAS  PubMed  Google Scholar 

Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol. 2006;6:836–48.

Article  CAS  PubMed  Google Scholar 

Pages F, Vives V, Sautès-Fridman C, Fossiez F, Berger A, Cugnenc PH, et al. Control of tumor development by intratumoral cytokines. Immunol Lett. 1999;68:135–9.

Article  CAS  PubMed  Google Scholar 

Qin A. An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1. Front Oncol. 2023;13:1173467.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Triozzi P, Rinehart J. The role of IFN-beta in cancer therapy. Cancer Surv. 1989;8:799–808.

CAS  PubMed  Google Scholar 

Maxwell MB, Hom-Tedla MS, Yi J, Li S, Rivera SA, Yu J, et al. ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity. Cell. 2024;187:3390–3408.e19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang CA, Huang HY, Chang YS, Lin CL, Lai IL, Chang JG. DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression. Oncology. 2017;92:115–24.

Article  CAS  PubMed  Google Scholar 

An J, Woodward JJ, Lai W, Minie M, Sun X, Tanaka L, et al. Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1-Deficient Mice. Arthritis Rheumatol. 2018;70:1807–19.

Article  CAS  PubMed  Google Scholar 

Coderch C, Arranz-Herrero J, Nistal-Villan E, de Pascual-Teresa B, Rius-Rocabert S. The Many Ways to Deal with STING. Int J Mol Sci. 2023;24.

Willemsen J, Neuhoff MT, Hoyler T, Noir E, Tessier C, Sarret S, et al. TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammato