Guerado, E. & Caso, E. The physiopathology of avascular necrosis of the femoral head: an update. Injury 47, S16–S26 (2016).
Zhao, D. et al. Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J. Orthop. Transl. 21, 100–110 (2020).
Bullough, P. G. & DiCarlo, E. F. Subchondral avascular necrosis: a common cause of arthritis. Ann. Rheum. Dis. 49, 412–420 (1990).
Article CAS PubMed PubMed Central Google Scholar
Buddhiraju, A. et al. Epidemiology, management, and systematic review of surgical trends for patients who have osteonecrosis of the femoral head. J. Arthroplasty 40, S112–S119 (2025).
Ikeuchi, K. et al. Epidemiology of nontraumatic osteonecrosis of the femoral head in Japan. Mod. Rheumatol. 25, 278–281 (2015).
Seamon, J., Keller, T., Saleh, J. & Cui, Q. The pathogenesis of nontraumatic osteonecrosis. Arthritis 2012, 601763 (2012).
Article PubMed PubMed Central Google Scholar
Che, Z. et al. Emerging roles of growth factors in osteonecrosis of the femoral head. Front. Genet. 13, 1037190 (2022).
Article CAS PubMed PubMed Central Google Scholar
Yu, H. et al. Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head. BMC Musculoskelet. Disord. 21, 277 (2020).
Article CAS PubMed PubMed Central Google Scholar
Huang, C., Wen, Z., Niu, J., Lin, S. & Wang, W. Steroid-induced osteonecrosis of the femoral head: novel insight into the roles of bone endothelial cells in pathogenesis and treatment. Front. Cell Dev. Biol. 9, 777697 (2021).
Article PubMed PubMed Central Google Scholar
Migliorini, F. et al. Failure and progression to total hip arthroplasty among the treatments for femoral head osteonecrosis: a Bayesian network meta-analysis. Br. Med. Bull. 138, 112–125 (2021).
Swarup, I. et al. Implant survival and patient-reported outcomes after total hip arthroplasty in young patients. J. Arthroplasty 33, 2893–2898 (2018).
Evans, R. M. The steroid and thyroid hormone receptor superfamily. Science 240, 889–895 (1988).
Article CAS PubMed PubMed Central Google Scholar
Pratt, W. B. & Toft, D. O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18, 306–360 (1997).
Pratt, W. B. & Toft, D. O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med. 228, 111–133 (2003).
Grad, I. & Picard, D. The glucocorticoid responses are shaped by molecular chaperones. Mol. Cell. Endocrinol. 275 (2007).
George, G. & Lane, J. M. Osteonecrosis of the femoral head. J. Am. Acad. Orthop. Surg. Glob. Res. Rev. 6 (2022).
Konarski, W. et al. Osteonecrosis related to steroid and alcohol use-an update on pathogenesis. Healthcare 11, 1846 (2023).
Maestro-Paramio, L., García-Rey, E., Bensiamar, F. & Saldaña, L. Osteoblast function in patients with idiopathic osteonecrosis of the femoral head : implications for a possible novel therapy. Bone Jt. Res. 10, 619–628 (2021).
Liao, Z. et al. Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head. Commun. Biol. 5, 324 (2022).
Article CAS PubMed PubMed Central Google Scholar
Feng, S. et al. Abnormal spatial patterns of intrinsic brain activity in osteonecrosis of the femoral head: a resting-state functional magnetic resonance imaging study. Front. Hum. Neurosci. 14, 551470 (2020).
Article PubMed PubMed Central Google Scholar
Sakamoto, Y. et al. Genome-wide association study of idiopathic osteonecrosis of the femoral head. Sci. Rep. 7, 15035 (2017).
Article PubMed PubMed Central Google Scholar
Xing, X.-X. et al. High-order brain networks abnormalities in osteonecrosis of the femoral head patients: an independent component analysis of resting-state fMRI. Pain Physician 25, E1475–E1484 (2022).
Zlotorowicz, M., Czubak, J., Caban, A., Kozinski, P. & Boguslawska-Walecka, R. The blood supply to the femoral head after posterior fracture/dislocation of the hip, assessed by CT angiography. Bone Jt. J. 95-B, 1453–1457 (2013).
Zheng, G.-S., Qiu, X., Wang, B.-J. & Zhao, D.-W. Relationship between blood flow and collapse of nontraumatic osteonecrosis of the femoral head. J. Bone Jt. Surg. Am. 104, 13–18 (2022).
Boss, J. H. & Misselevich, I. Osteonecrosis of the femoral head of laboratory animals: the lessons learned from a comparative study of osteonecrosis in man and experimental animals. Vet. Pathol. 40, 345–354 (2003).
Article CAS PubMed Google Scholar
Li, P. et al. Quantitative analysis of local microcirculation changes in early osteonecrosis of femoral head: DCE-MRI findings. Front. Surg. 9, 1003879 (2022).
Drescher, W. et al. Selective reduction of bone blood flow by short-term treatment with high-dose methylprednisolone. An experimental study in pigs. J. Bone Jt. Surg. Br. 83, 274–277 (2001).
Wu, R.-W. et al. S100 calcium binding protein A9 represses angiogenic activity and aggravates osteonecrosis of the femoral head. Int. J. Mol. Sci. 20, 5768 (2019).
Guo, M. & Zhang, J. Vitamin B2 prevents glucocorticoid-caused damage of blood vessels in osteonecrosis of the femoral head. Biomed. Res. Int. 2022, 4006184 (2022).
Article PubMed PubMed Central Google Scholar
Fraitzl, C. R., Kappe, T., Brugger, A., Billich, C. & Reichel, H. Reduced head-neck offset in nontraumatic osteonecrosis of the femoral head. Arch. Orthop. Trauma Surg. 133, 1055–1060 (2013).
Karasuyama, K. et al. The role of sclerotic changes in the starting mechanisms of collapse: a histomorphometric and FEM study on the femoral head of osteonecrosis. Bone 81, 644–648 (2015).
Tingart, M. et al. Influence of factors regulating bone formation and remodeling on bone quality in osteonecrosis of the femoral head. Calcif. Tissue Int. 82, 300–308 (2008).
Article CAS PubMed Google Scholar
Wang, L., You, X., Zhang, L., Zhang, C. & Zou, W. Mechanical regulation of bone remodeling. Bone Res. 10, 16 (2022).
Article CAS PubMed PubMed Central Google Scholar
Du, G. et al. Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes. Exp. Biol. Med. 245, 180–189 (2020).
Qin, L. et al. Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone Res. 9, 44 (2021).
Article CAS PubMed PubMed Central Google Scholar
Xu, X. et al. Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone. Int. J. Mol. Sci. 22, 6429 (2021).
Wan, Q.-Q. et al. Crosstalk between bone and nerves within bone. Adv. Sci. 8, 2003390 (2021).
Jia, S. et al. Calcitonin gene-related peptide enhances osteogenic differentiation and recruitment of bone marrow mesenchymal stem cells in rats. Exp. Ther. Med. 18, 1039–1046 (2019).
CAS PubMed PubMed Central Google Scholar
Liu, X. et al. Postmenopausal osteoporosis is associated with the regulation of SP, CGRP, VIP, and NPY. Biomed. Pharmacother. 104, 742–750 (2018).
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