Advances in the mechanism for steroid-induced osteonecrosis of the femoral head

Guerado, E. & Caso, E. The physiopathology of avascular necrosis of the femoral head: an update. Injury 47, S16–S26 (2016).

Article  PubMed  Google Scholar 

Zhao, D. et al. Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J. Orthop. Transl. 21, 100–110 (2020).

Google Scholar 

Bullough, P. G. & DiCarlo, E. F. Subchondral avascular necrosis: a common cause of arthritis. Ann. Rheum. Dis. 49, 412–420 (1990).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buddhiraju, A. et al. Epidemiology, management, and systematic review of surgical trends for patients who have osteonecrosis of the femoral head. J. Arthroplasty 40, S112–S119 (2025).

Article  PubMed  Google Scholar 

Ikeuchi, K. et al. Epidemiology of nontraumatic osteonecrosis of the femoral head in Japan. Mod. Rheumatol. 25, 278–281 (2015).

Article  PubMed  Google Scholar 

Seamon, J., Keller, T., Saleh, J. & Cui, Q. The pathogenesis of nontraumatic osteonecrosis. Arthritis 2012, 601763 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Che, Z. et al. Emerging roles of growth factors in osteonecrosis of the femoral head. Front. Genet. 13, 1037190 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu, H. et al. Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head. BMC Musculoskelet. Disord. 21, 277 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang, C., Wen, Z., Niu, J., Lin, S. & Wang, W. Steroid-induced osteonecrosis of the femoral head: novel insight into the roles of bone endothelial cells in pathogenesis and treatment. Front. Cell Dev. Biol. 9, 777697 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Migliorini, F. et al. Failure and progression to total hip arthroplasty among the treatments for femoral head osteonecrosis: a Bayesian network meta-analysis. Br. Med. Bull. 138, 112–125 (2021).

Article  PubMed  Google Scholar 

Swarup, I. et al. Implant survival and patient-reported outcomes after total hip arthroplasty in young patients. J. Arthroplasty 33, 2893–2898 (2018).

Article  PubMed  Google Scholar 

Evans, R. M. The steroid and thyroid hormone receptor superfamily. Science 240, 889–895 (1988).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pratt, W. B. & Toft, D. O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18, 306–360 (1997).

CAS  PubMed  Google Scholar 

Pratt, W. B. & Toft, D. O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med. 228, 111–133 (2003).

Article  CAS  Google Scholar 

Grad, I. & Picard, D. The glucocorticoid responses are shaped by molecular chaperones. Mol. Cell. Endocrinol. 275 (2007).

George, G. & Lane, J. M. Osteonecrosis of the femoral head. J. Am. Acad. Orthop. Surg. Glob. Res. Rev. 6 (2022).

Konarski, W. et al. Osteonecrosis related to steroid and alcohol use-an update on pathogenesis. Healthcare 11, 1846 (2023).

Maestro-Paramio, L., García-Rey, E., Bensiamar, F. & Saldaña, L. Osteoblast function in patients with idiopathic osteonecrosis of the femoral head : implications for a possible novel therapy. Bone Jt. Res. 10, 619–628 (2021).

Article  Google Scholar 

Liao, Z. et al. Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head. Commun. Biol. 5, 324 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng, S. et al. Abnormal spatial patterns of intrinsic brain activity in osteonecrosis of the femoral head: a resting-state functional magnetic resonance imaging study. Front. Hum. Neurosci. 14, 551470 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Sakamoto, Y. et al. Genome-wide association study of idiopathic osteonecrosis of the femoral head. Sci. Rep. 7, 15035 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Xing, X.-X. et al. High-order brain networks abnormalities in osteonecrosis of the femoral head patients: an independent component analysis of resting-state fMRI. Pain Physician 25, E1475–E1484 (2022).

PubMed  Google Scholar 

Zlotorowicz, M., Czubak, J., Caban, A., Kozinski, P. & Boguslawska-Walecka, R. The blood supply to the femoral head after posterior fracture/dislocation of the hip, assessed by CT angiography. Bone Jt. J. 95-B, 1453–1457 (2013).

Article  CAS  Google Scholar 

Zheng, G.-S., Qiu, X., Wang, B.-J. & Zhao, D.-W. Relationship between blood flow and collapse of nontraumatic osteonecrosis of the femoral head. J. Bone Jt. Surg. Am. 104, 13–18 (2022).

Article  Google Scholar 

Boss, J. H. & Misselevich, I. Osteonecrosis of the femoral head of laboratory animals: the lessons learned from a comparative study of osteonecrosis in man and experimental animals. Vet. Pathol. 40, 345–354 (2003).

Article  CAS  PubMed  Google Scholar 

Li, P. et al. Quantitative analysis of local microcirculation changes in early osteonecrosis of femoral head: DCE-MRI findings. Front. Surg. 9, 1003879 (2022).

Article  PubMed  Google Scholar 

Drescher, W. et al. Selective reduction of bone blood flow by short-term treatment with high-dose methylprednisolone. An experimental study in pigs. J. Bone Jt. Surg. Br. 83, 274–277 (2001).

Article  CAS  Google Scholar 

Wu, R.-W. et al. S100 calcium binding protein A9 represses angiogenic activity and aggravates osteonecrosis of the femoral head. Int. J. Mol. Sci. 20, 5768 (2019).

Guo, M. & Zhang, J. Vitamin B2 prevents glucocorticoid-caused damage of blood vessels in osteonecrosis of the femoral head. Biomed. Res. Int. 2022, 4006184 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Fraitzl, C. R., Kappe, T., Brugger, A., Billich, C. & Reichel, H. Reduced head-neck offset in nontraumatic osteonecrosis of the femoral head. Arch. Orthop. Trauma Surg. 133, 1055–1060 (2013).

Article  PubMed  Google Scholar 

Karasuyama, K. et al. The role of sclerotic changes in the starting mechanisms of collapse: a histomorphometric and FEM study on the femoral head of osteonecrosis. Bone 81, 644–648 (2015).

Article  PubMed  Google Scholar 

Tingart, M. et al. Influence of factors regulating bone formation and remodeling on bone quality in osteonecrosis of the femoral head. Calcif. Tissue Int. 82, 300–308 (2008).

Article  CAS  PubMed  Google Scholar 

Wang, L., You, X., Zhang, L., Zhang, C. & Zou, W. Mechanical regulation of bone remodeling. Bone Res. 10, 16 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du, G. et al. Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes. Exp. Biol. Med. 245, 180–189 (2020).

Article  CAS  Google Scholar 

Qin, L. et al. Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues. Bone Res. 9, 44 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu, X. et al. Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone. Int. J. Mol. Sci. 22, 6429 (2021).

Wan, Q.-Q. et al. Crosstalk between bone and nerves within bone. Adv. Sci. 8, 2003390 (2021).

Article  CAS  Google Scholar 

Jia, S. et al. Calcitonin gene-related peptide enhances osteogenic differentiation and recruitment of bone marrow mesenchymal stem cells in rats. Exp. Ther. Med. 18, 1039–1046 (2019).

CAS  PubMed  PubMed Central  Google Scholar 

Liu, X. et al. Postmenopausal osteoporosis is associated with the regulation of SP, CGRP, VIP, and NPY. Biomed. Pharmacother. 104, 742–750 (2018).

Comments (0)

No login
gif