Higher Serum Levels of Propionylcarnitine and Methionine are Associated with Reduced Cortical Amyloid Burden in Alzheimer’s Disease

Abdulrazzaq SB, Abu-Samak M, Omar A, Barakat M, Alzaghari LF, Mosleh I et al (2024) The effect of vitamin D3 and omega-3 combination, taken orally, on triglycerides, lining of intestine, and the biodiversity of gut microbiota in healthy rats. J Appl Microbiol 135(9). https://doi.org/10.1093/jambio/lxae223

Al-Najjar MAA, Abdulrazzaq SB, Alzaghari LF, Mahmod AI, Omar A, Hasen E et al (2024) Evaluation of Immunomodulatory potential of probiotic conditioned medium on murine macrophages. Sci Rep 14(1):7126. https://doi.org/10.1038/s41598-024-56622-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B et al (2020) Sex and APOE ε4 genotype modify the alzheimer’s disease serum metabolome. Nat Commun 11(1):1148. https://doi.org/10.1038/s41467-020-14959-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arrigoni-Martelli E, Caso V (2001) Carnitine protects mitochondria and removes toxic acyls from xenobiotics. Drugs Under Exp Clin Res 27:27–49

CAS  Google Scholar 

Azargoonjahromi A (2018) Abstract of medical biochemistry (Metabolism). Harper-Lehninger-Devlin

Azargoonjahromi A (2023) Dual role of nitric oxide in alzheimer’s disease. Nitric Oxide 134–135:23–37. https://doi.org/10.1016/j.niox.2023.03.003

Article  CAS  PubMed  Google Scholar 

Azargoonjahromi A (2024) The duality of amyloid-β: its role in normal and alzheimer’s disease States. Mol Brain 17(1):44. https://doi.org/10.1186/s13041-024-01118-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azargoonjahromi A, Ashrafi M, Abroushan D, Ramezannezhad E, Sadeghi M, Pooresmaeil Niaki SR et al High-Density lipoprotein (HDL) subtypes adversely alter brain structure in mild cognitive impairment: A Tensor-Based morphometry analysis. MedRxiv. 2024:2024.08. 20.24312114.

Barakat M, Thiab S, Alzaghari L, Abdulrazzaq S, Hasen E, Feras Abuarab S et al (2025) Cannabis and the immune response: A comprehensive review of therapeutic potential and concerns. Phytomedicine Plus 5:100876. https://doi.org/10.1016/j.phyplu.2025.100876

Article  CAS  Google Scholar 

Bekdash RA, Methyl, Donors (2023) Epigenetic Alterations, and brain health: Understanding the connection. Int J Mol Sci 24(3). https://doi.org/10.3390/ijms24032346

Broderick TL (2008) ATP production and TCA activity are stimulated by propionyl-L-carnitine in the diabetic rat heart. Drugs R D 9(2):83–91. https://doi.org/10.2165/00126839-200809020-00003

Article  CAS  PubMed  Google Scholar 

Broderick TL, Paulson DJ, Gillis M (2004) Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart. Drugs R D 5(4):191–201. https://doi.org/10.2165/00126839-200405040-00002

Article  CAS  PubMed  Google Scholar 

Cappuccio G, Atwal PS, Donti TR, Ugarte K, Merchant N, Craigen WJ et al (2017) Expansion of the phenotypic spectrum of propionic acidemia with isolated elevated Propionylcarnitine. JIMD Rep 35:33–37. https://doi.org/10.1007/8904_2016_21

Article  PubMed  Google Scholar 

Chen K, Roontiva A, Thiyyagura P, Lee W, Liu X, Ayutyanont N et al (2015) Improved power for characterizing longitudinal amyloid-β PET changes and evaluating amyloid-modifying treatments with a cerebral white matter reference region. J Nucl Med 56(4):560–566. https://doi.org/10.2967/jnumed.114.149732

Article  CAS  PubMed  Google Scholar 

Ciavardelli D, Piras F, Consalvo A, Rossi C, Zucchelli M, Di Ilio C et al (2016) Medium-chain plasma acylcarnitines, ketone levels, cognition, and Gray matter volumes in healthy elderly, mildly cognitively impaired, or alzheimer’s disease subjects. Neurobiol Aging 43:1–12. https://doi.org/10.1016/j.neurobiolaging.2016.03.005

Article  CAS  PubMed  Google Scholar 

D’Alessandro MCB, Kanaan S, Geller M, Praticò D, Daher JPL (2025) Mitochondrial dysfunction in alzheimer’s disease. Ageing Res Rev 107:102713. https://doi.org/10.1016/j.arr.2025.102713

Article  CAS  PubMed  Google Scholar 

Dayon L, Guiraud SP, Corthésy J, Da Silva L, Migliavacca E, Tautvydaitė D et al (2017) One-carbon metabolism, cognitive impairment and CSF measures of alzheimer pathology: homocysteine and beyond. Alzheimers Res Ther 9(1):43. https://doi.org/10.1186/s13195-017-0270-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ducker GS, Rabinowitz JD (2017) One-Carbon metabolism in health and disease. Cell Metab 25(1):27–42. https://doi.org/10.1016/j.cmet.2016.08.009

Article  CAS  PubMed  Google Scholar 

Epis R, Marcello E, Gardoni F, Longhi A, Calvani M, Iannuccelli M et al (2008) Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons. Eur J Pharmacol 597:51–56. https://doi.org/10.1016/j.ejphar.2008.09.001

Article  CAS  PubMed  Google Scholar 

Ferreira GC, McKenna MC (2017) L-Carnitine and Acetyl-L-carnitine roles and neuroprotection in developing brain. Neurochem Res 42(6):1661–1675. https://doi.org/10.1007/s11064-017-2288-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fleisher AS, Chen K, Liu X, Roontiva A, Thiyyagura P, Ayutyanont N et al (2011) Using positron emission tomography and Florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to alzheimer disease. Arch Neurol 68(11):1404–1411. https://doi.org/10.1001/archneurol.2011.150

Article  PubMed  Google Scholar 

Gutierrez-Tordera L, Panisello L, García-Gonzalez P, Ruiz A, Cantero JL, Rojas-Criollo M et al (2025) Metabolic signature of insulin resistance and risk of alzheimer’s disease. Journals Gerontology: Ser A 80(3):glae283. https://doi.org/10.1093/gerona/glae283

Article  CAS  Google Scholar 

Held PK, Singh E, Scott Schwoerer J (2022) Screening for methylmalonic and propionic acidemia: clinical outcomes and Follow-Up recommendations. Int J Neonatal Screen 8(1). https://doi.org/10.3390/ijns8010013

Hooshmand B, Refsum H, Smith AD, Kalpouzos G, Mangialasche F, von Arnim CAF et al (2019) Association of methionine to homocysteine status with brain magnetic resonance imaging measures and risk of dementia. JAMA Psychiatry 76(11):1198–1205. https://doi.org/10.1001/jamapsychiatry.2019.1694

Article  PubMed  PubMed Central  Google Scholar 

Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M et al (2022) Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of alzheimer’s disease. Alzheimers Dement 18(6):1260–1278. https://doi.org/10.1002/alz.12468

Article  CAS  PubMed  Google Scholar 

Huguenard CJC, Cseresznye A, Evans JE, Darcey T, Nkiliza A, Keegan AP et al (2023) APOE ε4 and alzheimer’s disease diagnosis associated differences in L-carnitine, GBB, TMAO, and acylcarnitines in blood and brain. Curr Res Transl Med 71(1):103362. https://doi.org/10.1016/j.retram.2022.103362

Article  CAS  PubMed  Google Scholar 

Huo Z, Yu L, Yang J, Zhu Y, Bennett DA, Zhao J (2020) Brain and blood metabolome for alzheimer’s dementia: findings from a targeted metabolomics analysis. Neurobiol Aging 86:123–133. https://doi.org/10.1016/j.neurobiolaging.2019.10.014

Article  CAS  PubMed  Google Scholar 

Jia K, Tian J, Wang T, Guo L, Xuan Z, Swerdlow RH et al (2023) Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of alzheimer disease. JCI Insight 8(22). https://doi.org/10.1172/jci.insight.174290

Kadyrov M, Whiley L, Brown B, Erickson KI, Holmes E (2022) Associations of the lipidome with Ageing, cognitive decline and exercise behaviours. Metabolites. https://doi.org/10.3390/metabo12090822

Article  PubMed  PubMed Central  Google Scholar 

Kueper JK, Speechley M, Montero-Odasso M (2018) The alzheimer’s disease assessment Scale-Cognitive subscale (ADAS-Cog): modifications and responsiveness in Pre-Dementia Populations. A narrative review. J Alzheimers Dis 63(2):423–444. https://doi.org/10.3233/jad-170991

Article  PubMed  PubMed Central  Google Scholar 

Ma X, Wang XM, Tang GZ, Wang Y, Liu XC, Wang SD et al (2025) Alterations of amino acids in older adults with alzheimer’s disease and vascular dementia. Amino Acids 57(1):10. https://doi.org/10.1007/s00726-024-03442-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on alzheimer’s disease. Neurology 34(7):939–944. https://doi.org/10.1212/wnl.34.7.939

Article  CAS  PubMed 

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