Adam-Dima, I., Olteanu, A. A., Olaru, O. T., Popa, D. E., & Purdel, C. (2024). Methods of analysis of phytoestrogenic compounds: An up-to-date of the present state. Separations, 11, 205.
Bansal, S., Mahendiratta, S., Agrawal, M., Kumar, S., Sharma, A. R., Garg, N., Sarma, P., Prakash, A., Chopra, K., & Medhi, B. (2021). Role of protein tyrosine phosphatase 1B inhibitor in central insulin resistance and associated cognitive deficits. Brain Research Bulletin, 171, 113–125.
Article CAS PubMed Google Scholar
Bansal, S., Swami, R., Bansal, N., Chaudhary, R., Mahendiratta, S., Kaur, H., Chopra, K., & Medhi, B. (2024). Evidence-based neuroprotective potential of nonfeminizing estrogens: In vitro and in vivo studies. European Journal of Neuroscience, 60, 6046–6056.
Article CAS PubMed Google Scholar
Bhatt, S., Radhakrishnan, M., Jindal, A., Devadoss, T., & Dhar, A. K. (2014). Neuropharmacological evaluation of a novel 5-HT3 receptor antagonist (6 g) on chronic unpredictable mild stress-induced changes in behavioural and brain oxidative stress parameters in mice. Indian Journal of Pharmacology, 46, 191–196.
Article CAS PubMed PubMed Central Google Scholar
Chang, M., Zhang, L., Dai, H., & Sun, L. (2021). Genistein acts as antidepressant agent against chronic mild stress-induced depression model of rats through augmentation of brain‐derived neurotrophic factor. Brain and Behavior, 11, Article e2300.
Article CAS PubMed PubMed Central Google Scholar
Chantalat, E., Valera, M.-C., Vaysse, C., Noirrit, E., Rusidze, M., Weyl, A., Vergriete, K., Buscail, E., Lluel, P., & Fontaine, C. (2020). Estrogen receptors and endometriosis. International Journal of Molecular Sciences, 21, Article 2815.
Article CAS PubMed PubMed Central Google Scholar
Chaudhary, R., Bag, S., Bansal, N., Lal, R., Bishnoi, M., Kondepudi, K. K., Chopra, K., & Bansal, S. (2025). Soy Isoflavone Ameliorates Gut-brain axis Dysfunction via ER-β Activation and β-glucuronidase Modulation in Estrogen-Deficient Rats. European Journal of Pharmacology, 1013, 1 78503.
Chaudhary, R., Bansal, N., Kaur, A., Gupta, S., Chopra, K., & Bansal, S. (2025). Gut microbiota metabolic axis dysfunction in estrogen deficient stressed rats. Naunyn-Schmiedeberg’s Archives of Pharmacology, (1), 19. https://doi.org/10.1007/s00210-025-04399-y
Chaudhary, R., Lal, R., Bansal, N., Garg, N., Bishnoi, M., Kondepudi, K. K., Saini, R. V., Gupta, S., Chopra, K., & Bansal, S. (2025). Gut Microbiota Dysbiosis and Neuroimmune Alterations in a Postmenopausal-Stress Rat Model. Journal of Neuroimmune Pharmacology, 20, 1–20.
Chavda, V. P., Chaudhari, A. Z., Balar, P. C., Gholap, A., & Vora, L. K. (2024). Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance. Phytotherapy Research, 38, 3060–3079.
Article CAS PubMed Google Scholar
Chen, C. Y. (1997). Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. Journal of Nutrition, 127, 263–269.
Chen, P., Li, B., & Ou-Yang, L. (2022). Role of estrogen receptors in health and disease. Frontiers in Endocrinology, 13, Article 839005.
Article PubMed PubMed Central Google Scholar
Chiba, S., Numakawa, T., Ninomiya, M., Richards, M. C., Wakabayashi, C., & Kunugi, H. (2012). Chronic restraint stress causes anxiety-and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 39, 112–119.
Article CAS PubMed Google Scholar
Choi, J. S., Koh, I.-U., & Song, J. (2012). Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats. Nutrition Research, 32, 844–855.
Article CAS PubMed Google Scholar
Comparetto, C., & Borruto, F. (2023). Treatments and management of menopausal symptoms: current status and future challenges. In: LIDSEN Publishing Inc. (pp. 1–47).
Daman, R., & Miglani, M. (2024). Genistein: A Multifaceted Flavonoid with Diverse Medicinal Applications.
Fukuda, K., Yao, H., Ibayashi, S., Nakahara, T., Uchimura, H., & Fujishima, M. (2000). Ovariectomy exacerbates and estrogen replacement attenuates photothrombotic focal ischemic brain injury in rats. Stroke, 31, 155–160.
Article CAS PubMed Google Scholar
Ganem, A. B. (2025). Effects of Chronic Stress on Women’s Health in Modern Society: A Proposal for Cognitive Behavioral Therapy and Mindfulness Techniques. Saint Mary’s College of California.
Goyal, N., Chaudhary, R., Aggarwal, K., Kumar, H., Bansal, N., Gupta, S., & Bansal, S. (2025). Red Clover Supplementation Alleviates Neurological Deficits in Estrogen Deficient Rats Exposed to Chronic Unpredictable Mild Stress. European Journal of Neuroscience, 61, Article e70164.
Article CAS PubMed Google Scholar
Gueroui, M., & Kechrid, Z. (2016). Evaluation of some biochemical parameters and brain oxidative stress in experimental rats exposed chronically to silver nitrate and the protective role of vitamin E and selenium. Toxicological Research, 32, 301–309.
Article CAS PubMed PubMed Central Google Scholar
Habibi, P., Babri, S., Ahmadiasl, N., & Yousefi, H. (2017). Effects of genistein and swimming exercise on spatial memory and expression of microRNA 132, BDNF, and IGF-1 genes in the hippocampus of ovariectomized rats. Iranian Journal of Basic Medical Sciences, 20, 856.
PubMed PubMed Central Google Scholar
Hogan, A. M., Collins, D., Baird, A. W., & Winter, D. C. (2009). Estrogen and its role in gastrointestinal health and disease. International Journal of Colorectal Disease, 24, 1367–1375.
Hou, N. N., Zhu, Y. M., & Huang, H. F. (2006). The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism. Fen Zi Xi Bao Sheng Wu Xue Bao = Journal of Molecular Cell Biology, 39, 289–296.
Hou, Y., Qian, H., Yao, R., Yu, Z., Wang, J., Dai, J., Cui, W., Li, J., & Zhao, X. (2025). Untargeted metabolomics revealed that quercetin inhibited ferroptosis by improving metabolic disorder in the hippocampus of perimenopausal depression model rats. Molecular Neurobiology, 62, 2872–2888.
Article CAS PubMed Google Scholar
Ige, A. O., Adebayo, O. O., Adele, B. O., Odetola, A. O., Emediong, I. E., & Adewoye, E. O. (2022). Genistein mitigates the gastro-toxic effects of bisphenol A in male wistar rats. Journal of Biosciences and Medicines, 10, 60–78.
Javani, G., Alihemmati, A., Habibi, P., Yousefi, H., Karimi, P., Ebraheimi, V., & Ahmadiasl, N. (2019). The effects of genistein on renal oxidative stress and inflammation of ovariectomized rats. Jundishapur Journal of Natural Pharmaceutical Products, 14, Article e57149.
Kageyama, A., Sakakibara, H., Zhou, W., Yoshioka, M., Ohsumi, M., Shimoi, K., & Yokogoshi, H. (2010). Genistein regulated serotonergic activity in the hippocampus of ovariectomized rats under forced swimming stress. Bioscience, Biotechnology, and Biochemistry, 74, 2005–2010.
Article CAS PubMed Google Scholar
Kattna, A., & Singh, L. (2025). Genistein as a renoprotective agent: Mechanistic insights into antioxidant, anti-inflammatory, and fibrosis-regulating pathways. Molecular Biology Reports, 52, 500.
Article CAS PubMed Google Scholar
Kaur, S. P., Bansal, S., & Chopra, K. (2015). 17α-Estradiol: A candidate neuroserm and non-feminizing estrogen for postmenopausal neuronal complications. Steroids, 96, 7–15.
Article CAS PubMed Google Scholar
Khodamoradi, M., Ghazvini, H., Esmaeili-Mahani, S., Shahveisi, K., Farnia, V., Zhaleh, H., Abdoli, N., Akbarnejad, Z., Saadati, H., & Sheibani, V. (2018). Genistein attenuates seizure-induced hippocampal brain-derived neurotrophic factor overexpression in ovariectomized rats. Journal of Chemical Neuroanatomy, 89, 43–50.
Article CAS PubMed Google Scholar
King, R. A., Broadbent, J. L., & Head, R. J. (1996). Absorption and excretion of the soy isoflavone genistein in rats. Journal of Nutrition, 126, 176–182.
Article CAS PubMed Google Scholar
Koshkina, A., Dudnichenko, T., Baranenko, D., Fedotova, J., & Drago, F. (2019). Effects of vitamin D3 in long-term ovariectomized rats subjected to chronic unpredictable mild stress: BDNF, NT-3, and NT-4 implications. Nutrients, 11, 1726.
Article CAS PubMed PubMed Central Google Scholar
Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., Van Der Saag, P. T., Van Der Burg, B., & Gustafsson, J.-A. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology, 139, 4252–4263.
Article CAS PubMed Google Scholar
Lagranha, C. J., Silva, T. L. A., Silva, S. C. A., Braz, G. R. F., da Silva, A. I., Fernandes, M. P., & Sellitti, D. F. (2018). Protective effects of estrogen against cardiovascular disease mediated via oxidative stress in the brain. Life Sciences, 192, 190–198.
Comments (0)