SAT1 Knockdown Decreases Glutamate-Induced Oxidative Stress, Ferroptosis, and Apoptosis in HT22 Cells via Activating the Nrf2/ARE Pathway

Acevedo, K., Masaldan, S., Opazo, C. M., & Bush, A. I. (2019). Redox active metals in neurodegenerative diseases. Journal of Biological Inorganic Chemistry, 24(8), 1141–1157.

Article  PubMed  Google Scholar 

Akyuz, E., Doganyigit, Z., Eroglu, E., Moscovicz, F., Merelli, A., Lazarowski, A., & Auzmendi, J. (2021). Myocardial iron overload in an experimental model of sudden unexpected death in epilepsy. Frontiers in Neurology, 12, 609236.

Article  PubMed  PubMed Central  Google Scholar 

Azadmanesh, M., Farkhondeh, T., Harifi-Mood, M. S., Aschner, M., Samini, F., & Samarghandian, S. (2025). Role of Nrf2 in epilepsy treatment. Current Molecular Medicine, 25(8), 980–990.

Article  PubMed  Google Scholar 

Balestrini, S., Arzimanoglou, A., Blumcke, I., Scheffer, I. E., Wiebe, S., Zelano, J., & Walker, M. C. (2021). The aetiologies of epilepsy. Epileptic Disorders, 23(1), 1–16.

Article  PubMed  Google Scholar 

Barker-Haliski, M., & White, H. S. (2015). Glutamatergic mechanisms associated with seizures and epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863.

Article  PubMed  PubMed Central  Google Scholar 

Cai, Y., & Yang, Z. (2021). Ferroptosis and its role in epilepsy. Frontiers in Cellular Neuroscience, 15, 696889.

Article  PubMed  PubMed Central  Google Scholar 

Carmona-Aparicio, L., Perez-Cruz, C., Zavala-Tecuapetla, C., Granados-Rojas, L., Rivera-Espinosa, L., Montesinos-Correa, H., Hernandez-Damian, J., Pedraza-Chaverri, J., Sampieri, A., Coballase-Urrutia, E., & Cardenas-Rodriguez, N. (2015). Overview of Nrf2 as therapeutic target in epilepsy. International Journal of Molecular Sciences, 16(8), 18348–18367.

Article  PubMed  PubMed Central  Google Scholar 

Chang, S. J., & Yu, B. C. (2010). Mitochondrial matters of the brain: Mitochondrial dysfunction and oxidative status in epilepsy. Journal of Bioenergetics and Biomembranes, 42(6), 457–459.

Article  PubMed  Google Scholar 

Chen, G. H., Song, C. C., Pantopoulos, K., Wei, X. L., Zheng, H., & Luo, Z. (2022). Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway. Free Radical Biology and Medicine, 180, 95–107.

Article  PubMed  Google Scholar 

Chen, F., Kang, R., Liu, J., & Tang, D. (2023). The ACSL4 network regulates cell death and autophagy in diseases. Biology, 12(6), 864.

Article  PubMed  PubMed Central  Google Scholar 

Dang, Y., He, Q., Yang, S., Sun, H., Liu, Y., Li, W., Tang, Y., Zheng, Y., & Wu, T. (2022). FTH1- and SAT1-induced astrocytic ferroptosis is involved in alzheimer’s disease: Evidence from single-cell transcriptomic analysis. Pharmaceuticals, 15(10), 1177.

Article  PubMed  PubMed Central  Google Scholar 

Dionisio, P. A., Amaral, J. D., & Rodrigues, C. M. P. (2021). Oxidative stress and regulated cell death in Parkinson’s disease. Ageing Research Reviews, 67, 101263.

Article  PubMed  Google Scholar 

Dodson, M., Castro-Portuguez, R., & Zhang, D. D. (2019). NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biology, 23, 101107.

Article  PubMed  PubMed Central  Google Scholar 

Domanskyi, A., & Parlato, R. (2022). Oxidative stress in neurodegenerative diseases. Antioxidants, 11(3), 504.

Article  PubMed  PubMed Central  Google Scholar 

Dorfmuller, G., & Delalande, O. (2013). Pediatric epilepsy surgery. Handbook of Clinical Neurology, 111, 785–795.

Article  PubMed  Google Scholar 

Engelborghs, S., D’Hooge, R., & De Deyn, P. P. (2000). Pathophysiology of epilepsy. Acta Neurologica Belgica, 100(4), 201–213.

PubMed  Google Scholar 

Feng, L., Wang, C., Zhang, C., Zhang, W., Zhu, W., He, Y., Xia, Z., & Song, W. (2024). P38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model. Neural Regeneration Research, 19(10), 2299–2309.

Article  PubMed  Google Scholar 

Fine, A., & Wirrell, E. C. (2020). Seizures in children. Pediatrics in Review, 41(7), 321–347.

Article  PubMed  Google Scholar 

Fukui, M., Song, J. H., Choi, J., Choi, H. J., & Zhu, B. T. (2009). Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. European Journal of Pharmacology, 617(1–3), 1–11.

Article  PubMed  Google Scholar 

Geronzi, U., Lotti, F., & Grosso, S. (2018). Oxidative stress in epilepsy. Expert Review of Neurotherapeutics, 18(5), 427–434.

Article  PubMed  Google Scholar 

Grabarczyk, M., Justyńska, W., Czpakowska, J., Smolińska, E., Bielenin, A., Glabinski, A., & Szpakowski, P. (2024). Role of plant phytochemicals: Resveratrol, curcumin, luteolin and quercetin in demyelination, neurodegeneration, and epilepsy. Antioxidants, 13(11), 1364.

Article  PubMed  PubMed Central  Google Scholar 

Gruenbaum, B. F., Schonwald, A., Boyko, M., & Zlotnik, A. (2024). The role of glutamate and blood-brain barrier disruption as a mechanistic link between epilepsy and depression. Cells, 13(14), 1228.

Article  PubMed  PubMed Central  Google Scholar 

Guan, D. F., Ren, P. Y., Hu, W., & Zhang, Y. L. (2015). The mGluR5 positive allosteric modulator CDPPB inhibits SO2-induced protein radical formation and mitochondrial dysfunction through activation of Akt in mouse hippocampal HT22 cells. Cellular and Molecular Neurobiology, 35(4), 573–583.

Article  PubMed  Google Scholar 

Han, P., Wang, X., Zhou, T., Cheng, J., Wang, C., Sun, F., & Zhao, X. (2022). Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice. Free Radical Biology & Medicine, 193(Pt 1), 421–429.

Article  Google Scholar 

Handa, P., & Kowdley, K. V. (2016). A proton pump inhibitor a day keeps the iron away. Clinical Gastroenterology and Hepatology, 14(1), 153–155.

Article  PubMed  Google Scholar 

Hani, A. J., Mikati, H. M., & Mikati, M. A. (2015). Genetics of pediatric epilepsy. Pediatric Clinics of North America, 62(3), 703–722.

Article  PubMed  Google Scholar 

He, M., Liu, J., Cheng, S., Xing, Y., & Suo, W. Z. (2013). Differentiation renders susceptibility to excitotoxicity in HT22 neurons. Neural Regeneration Research, 8(14), 1297–1306.

Article  PubMed  PubMed Central  Google Scholar 

Huang, L., Xiao, W., Wang, Y., Li, J., Gong, J., Tu, E., Long, L., Xiao, B., Yan, X., & Wan, L. (2024). Metabotropic glutamate receptors (mGluRs) in epileptogenesis: An update on abnormal mGluRs signaling and its therapeutic implications. Neural Regeneration Research, 19(2), 360–368.

Article  PubMed  Google Scholar 

Jin, M. L., Park, S. Y., Kim, Y. H., Oh, J. I., Lee, S. J., & Park, G. (2014). The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells. Neurotoxicology, 41, 102–111.

Article  PubMed  Google Scholar 

Katyayan, A., & Diaz-Medina, G. (2021). Epilepsy: Epileptic syndromes and treatment. Neurologic Clinics, 39(3), 779–795.

Article  PubMed  Google Scholar 

Lewerenz, J., Hewett, S. J., Huang, Y., Lambros, M., Gout, P. W., Kalivas, P. W., Massie, A., Smolders, I., Methner, A., Pergande, M., Smith, S. B., Ganapathy, V., & Maher, P. (2013). The cystine/glutamate antiporter system xc-in health and disease: From molecular mechanisms to novel therapeutic opportunities. Antioxidants & redox signaling, 18(5), 522–555.

Li, L., Lin, G., Gu, H., Yu, L., & Ni, C. (2019). Effects of Srxn1 on growth and Notch signalling of astrocyte induced by hydrogen peroxide. Artificial Cells, Nanomedicine and Biotechnology, 47(1), 1917–1923.

Article  PubMed  Google Scholar 

Li, J., Jia, B., Cheng, Y., Song, Y., Li, Q., & Luo, C. (2022). Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders. Oxidative Medicine and Cellular Longevity, 2022, 3999083.

Article  PubMed  PubMed Central  Google Scholar 

Li, W., Wu, J., Zeng, Y., & Zheng, W. (2023). Neuroinflammation in epileptogenesis: From pathophysiology to therapeutic strategies. Frontiers in Immunology, 14, 1269241.

Article  PubMed  PubMed Central  Google Scholar 

Lin, Z., Liu, J., Kang, R., Yang, M., & Tang, D. (2021). Lipid metabolism in ferroptosis. Advanced Biology, 5(8), e2100396.

Article 

Comments (0)

No login
gif