Adler, O., Zait, Y., Cohen, N., et al. (2023). Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2 [J]. Nat Cancer, 4(3), 401–418.

Article  CAS  PubMed  Google Scholar 

Al-Kawaz, M. N., Hanley, D. F., & Ziai, W. (2020). Advances in therapeutic approaches for spontaneous intracerebral hemorrhage. Neurotherapeutics, 17(4), 1757–1767.

Article  PubMed  PubMed Central  Google Scholar 

An, J., Liu, Z., Wang, Y., et al. (2025). Drug delivery strategy of hemostatic drugs for intracerebral hemorrhage [J]. Journal Of Controlled Release : Official Journal Of The Controlled Release Society, 379, 202–220.

Article  CAS  PubMed  Google Scholar 

Argaw, A. T., Asp, L., Zhang, J., et al. (2012). Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. Journal of Clinical Investigation, 122(7), 2454–2468.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Argaw, A. T., Gurfein, B. T., Zhang, Y., et al. (2009). VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proceedings of the National Academy of Sciences of the United States of America, 106(6), 1977–1982.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonnard, B., El Moghrabi, S., Ueda, K., et al. (2023). Ngal is a novel target in hypertension by modulating the NCC-mediated renal Na balance. Hypertension, 80(9), 1860–1870.

Article  CAS  PubMed  Google Scholar 

Burek, M., König, A., Lang, M., et al. (2019). Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells [J]. Transl Stroke Res, 10(6), 672–683.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai, L. Y., Yuan, Y., Huang, H., et al. (2025). Mechanism of LCN2 in cerebral ischemia-reperfusion injury [J]. Front Neurosci, 19, 1536055.

Article  PubMed  PubMed Central  Google Scholar 

Chen, S., Chen, X. C., Lou, X. H., et al. (2019). Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage [J]. Clinica Chimica Acta, 492, 72–77.

Article  CAS  Google Scholar 

Chen, S., Li, L., Peng, C., et al. (2022). Targeting oxidative stress and inflammatory response for blood-brain barrier protection in intracerebral hemorrhage. Antioxidants & Redox Signaling, 37(1–3), 115–134.

Article  CAS  Google Scholar 

Chen, W., Li, W., Zhang, Z., et al. (2020). Lipocalin-2 Exacerbates Lupus Nephritis by Promoting Th1 Cell Differentiation [J]. Journal Of The American Society Of Nephrology, 31(10), 2263–2277.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chou, W. H., Wang, G., Kumar, V., et al. (2015). Lipocalin-2 in stroke. Neuro, 2(1), 38–41.

PubMed  PubMed Central  Google Scholar 

Coll, R. C., Schroder, K., & Pelegrín, P. (2022). Nlrp3 and pyroptosis blockers for treating inflammatory diseases. Trends in Pharmacological Sciences, 43(8), 653–668.

Article  CAS  PubMed  Google Scholar 

De Oliveira Manoel, A. L. (2020). Surgery for spontaneous intracerebral hemorrhage. Critical Care, 24(1), 45.

Article  PubMed  PubMed Central  Google Scholar 

Devireddy, L. R., Gazin, C., Zhu, X., et al. (2005). A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake [J]. Cell, 123(7), 1293–1305.

Article  CAS  PubMed  Google Scholar 

Diener, H. C., & Hankey, G. J. (2020). Primary and secondary prevention of ischemic stroke and cerebral hemorrhage: JACC focus seminar. Journal of the American College of Cardiology, 75(15), 1804–1818.

Article  PubMed  Google Scholar 

Doliwa, M., Kuzniewska, B., Nader, K., et al. (2025). Astrocyte-secreted Lcn2 modulates dendritic spine morphology. Cells. https://doi.org/10.3390/cells14030159

Article  PubMed  PubMed Central  Google Scholar 

Dong, M., XI, G., Keep, R. F., et al. (2013). Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats [J]. Brain Research, 1505, 86–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du, H., Lai, J., Lin, B., et al. (2025). LCN2 Regulates Microglia Polarization Through the p38MAPK-PGC-1α-PPARγ Pathway to Alleviate Traumatic Brain Injury [J]. Cell Biochemistry And Biophysics, 83(2), 2301–2311.

Article  CAS  PubMed  Google Scholar 

Du, Y., Li, W., Lin, L., et al. (2019). Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One, 14(7), Article e0218965.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Egashira, Y., Hua, Y., Keep, R. F., et al. (2014). Acute white matter injury after experimental subarachnoid hemorrhage: Potential role of lipocalin 2. Stroke, 45(7), 2141–2143.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eilenberg, W., Stojkovic, S., Kaider, A., et al. (2017). NGAL and MMP-9/NGAL as biomarkers of plaque vulnerability and targets of statins in patients with carotid atherosclerosis [J]. Clinical Chemistry And Laboratory Medicine, 56(1), 147–156.

Article  PubMed  Google Scholar 

Eilenberg, W., Stojkovic, S., Kaider, A., et al. (2019). Neutrophil Gelatinase Associated Lipocalin (NGAL) for Identification of Unstable Plaques in Patients with Asymptomatic Carotid Stenosis [J]. European Journal Of Vascular And Endovascular Surgery, 57(6), 768–777.

Article  PubMed  Google Scholar 

Eilenberg, W., Stojkovic, S., Piechota-polanczyk, A., et al. (2016). Neutrophil Gelatinase-Associated Lipocalin (NGAL) is Associated with Symptomatic Carotid Atherosclerosis and Drives Pro-inflammatory State In Vitro [J]. European Journal Of Vascular And Endovascular Surgery, 51(5), 623–631.

Article  CAS  PubMed  Google Scholar 

Eilenberg, W., Stojkovic, S., Piechota-polanczyk, A., et al. (2017). Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment [J]. Cardiovasc Diabetol, 16(1), 98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fei, X., Dou, Y. N., Wang, L., et al. (2022). Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage. Journal of Neuroinflammation, 19(1), Article 67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fei, X., Dou, Y., Yang, Y., et al. (2024). Lipocalin-2 inhibition alleviates neural injury by microglia ferroptosis suppression after experimental intracerebral hemorrhage in mice via enhancing ferritin light chain expression. Biochimica et Biophysica Acta (BBA), 1870(7), Article 167435.

Article  CAS  Google Scholar 

Floderer, M., Prchal-murphy, M., & Vizzardelli, C. (2014). Dendritic cell-secreted lipocalin2 induces CD8 + T-cell apoptosis, contributes to T-cell priming and leads to a TH1 phenotype. PLoS One, 9(7), Article e101881.

Article  PubMed  PubMed Central  Google Scholar 

Garg, R., & Biller, J. (2019). Recent advances in spontaneous intracerebral hemorrhage. F1000Research. https://doi.org/10.12688/f1000research.16357.1

Article  PubMed  PubMed Central  Google Scholar 

Greenberg, S. M., Ziai, W. C., Cordonnier, C., et al. (2022). 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association [J]. Stroke, 53(7), e282–e361.

Article  CAS  PubMed