Ariga, H., Takahashi-Niki, K., Kato, I., Maita, H., Niki, T., & Iguchi-Ariga, S. M. M. (2013). Neuroprotective function of DJ-1 in Parkinson’s disease. Oxidative Medicine and Cellular Longevity, 2013, Article 683920. https://doi.org/10.1155/2013/683920

Atakpa-Adaji, P., & Ivanova, A. (2023). IP3R at ER-mitochondrial contact sites: Beyond the IP3R-GRP75-VDAC1 Ca²⁺ funnel. Contact (Thousand Oaks), 6, 25152564231181020. https://doi.org/10.1177/25152564231181020

Article  PubMed  PubMed Central  Google Scholar 

Baltrusaitis, E. E., Ravitch, E. E., Fenton, A. R., Perez, T. A., Holzbaur, E. L., & Dominguez, R. (2023). Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK. Journal of Biological Chemistry, 299(12), 105441. https://doi.org/10.1016/j.jbc.2023.105441

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao, W., Ge, Y., Huang, J., Li, Y., Luo, Y., & Huang, N. (2025). DJ-1/PARK7 in Parkinson’s disease: Mechanisms of pathogenesis and therapeutic potential. Neuroscience, 587, 1–13. https://doi.org/10.1016/j.neuroscience.2025.09.025

Article  CAS  PubMed  Google Scholar 

Bayne, A. N., & Trempe, J. F. (2019). Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond. Cellular and Molecular Life Sciences, 76(23), 4589–4611. https://doi.org/10.1007/s00018-019-03203-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bean, B. P. (2024). Mechanisms of pacemaking in mammalian neurons. The Journal of physiology. https://doi.org/10.1113/JP284759

Article  PubMed  PubMed Central  Google Scholar 

Benhammouda, S., Vishwakarma, A., Gatti, P., & Germain, M. (2021). Mitochondria endoplasmic reticulum contact sites (MERCs): Proximity ligation assay as a tool to study organelle interaction. Frontiers in Cell and Developmental Biology, 9, 789959. https://doi.org/10.3389/fcell.2021.789959

Article  PubMed  PubMed Central  Google Scholar 

Berenguer-Escuder, C., Grossmann, D., Antony, P., Arena, G., Wasner, K., Massart, F., Jarazo, J., Walter, J., Schwamborn, J. C., Grünewald, A., & Krüger, R. (2020). Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease. Human Molecular Genetics, 29(8), 1353–1364. https://doi.org/10.1093/hmg/ddaa066

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bharat, V., & Wang, X. (2020). Precision neurology for Parkinson’s disease: Coupling Miro1-based diagnosis with drug discovery. Movement Disorders, 35(9), 1502–1508. https://doi.org/10.1002/mds.28194

Article  CAS  PubMed  Google Scholar 

Bharat, V., Durairaj, A. S., Vanhauwaert, R., Li, L., Muir, C. M., Chandra, S., Kwak, C. S., Guen, L., Nandakishore, Y., Hsieh, P., Rensi, C. H., Altman, S. E., Greicius, R. B., Feng, M. D., L., & Wang, X. (2023). A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson’s disease. Cell Reports, 42(12). https://doi.org/10.1016/j.celrep.2023.113544. Article 113544.

Birsa, N., Norkett, R., Wauer, T., Mevissen, T. E. T., Wu, H. C., Foltynie, T., Bhatia, K., Hirst, W. D., Komander, D., Plun-Favreau, H., & Kittler, J. T. (2014). Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. Journal of Biological Chemistry, 289(21), 14569–14582. https://doi.org/10.1074/jbc.M114.563031

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borbolis, F., Ploumi, C., & Palikaras, K. (2025). Calcium-mediated regulation of mitophagy: Implications in neurodegenerative diseases. npj Metabolism and Health Disease, 3(1). https://doi.org/10.1038/s44324-025-00049-2. Article 4.

Burré, J. (2015). The synaptic function of α-synuclein. Journal of Parkinson’s Disease, 5(4), 699–713. https://doi.org/10.3233/JPD-150642

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calabresi, P., Mechelli, A., Natale, G., Volpicelli-Daley, L., Di Lazzaro, G., Ghiglieri, V., & Mercuri, N. B. (2023). Alpha-synuclein in Parkinson’s disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction. Cell Death & Disease, 14(3), 176. https://doi.org/10.1038/s41419-023-05672-9

Article  Google Scholar 

Canty, J. T., Hensley, A., Aslan, M., Jack, A., & Yildiz, A. (2023). TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport. Nature Communications, 14, 1376. https://doi.org/10.1038/s41467-023-36945-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chemla, A., Arena, G., Sacripanti, G., Barmpa, K., Zagare, A., Garcia, P., & Saraiva, C. (2025a). Parkinson’s disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss. Brain, 148(10), 3607–3622. https://doi.org/10.1093/brain/awaf051

Article  PubMed  PubMed Central  Google Scholar 

Chemla, A., Arena, G., Sacripanti, G., Barmpa, K., Zagare, A., Garcia, P., Gorgogietas, V., Antony, P., Ohnmacht, J., Baron, A., Jung, J., Lind-Holm Mogensen, F., Michelucci, A., Marzesco, A. M., Buttini, M., Schmidt, T., Grünewald, A., Schwamborn, J. C., Krüger, R., & Saraiva, C. (2025b). Parkinson’s disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss. Brain, 148(10), 3607–3622. https://doi.org/10.1093/brain/awaf051

Article  PubMed  PubMed Central  Google Scholar 

Cheng, X. T., Huang, N., & Sheng, Z. H. (2022). Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration. Neuron, 110(12), 1899–1923. https://doi.org/10.1016/j.neuron.2022.03.015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi, G. E., Park, J. Y., Park, M. R., Chae, C. W., Jung, Y. H., Lim, J. R., Yoon, J. H., Cho, J. H., & Han, H. J. (2025). Restoration of Miro1’s N-terminal GTPase function alleviates prenatal stress-induced mitochondrial fission via Drp1 modulation. Cell Communication and Signaling, 23, 166. https://doi.org/10.1186/s12964-025-02172-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Ruisoto-Palomera, P., Tornero-Aguilera, J. F., & Ramos-Campo, D. J. (2023). Mitochondria and brain disease: A comprehensive review of pathological mechanisms and therapeutic opportunities. Biomedicines, 11(9), 2488. https://doi.org/10.3390/biomedicines11092488

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dolgacheva, L. P., Berezhnov, A. V., Fedotova, E. I., Zinchenko, V. P., & Abramov, A. Y. (2019). Role of DJ-1 in the mechanism of pathogenesis of Parkinson’s disease. Journal of Bioenergetics and Biomembranes, 51(3), 175–188. https://doi.org/10.1007/s10863-019-09798-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fatiga, F. F., Wang, L. J., Hsu, T., Capuno, J. I., & Fu, C. Y. (2021). Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca²⁺ levels. Journal of Cellular Biochemistry, 122(12), 1848–1862. https://doi.org/10.1002/jcb.30138

Article  CAS  PubMed  Google Scholar 

Gao, J., Sang, M., Zhang, X., Zheng, T., Pan, J., Dai, M., Zhou, L., & Yang, S. (2015). Miro1-mediated mitochondrial dysfunction under high nutrient stress is linked to NOD-like receptor 3 (NLRP3)-dependent inflammatory responses in rat pancreatic beta cells. Free Radical Biology & Medicine, 89, 322–332. https://doi.org/10.1016/j.freeradbiomed.2015.09.002

Article  CAS  Google Scholar 

Gao, V., Briano, J. A., Komer, L. E., & Burré, J. (2023). Functional and pathological effects of α-synuclein on synaptic SNARE complexes. Journal of Molecular Biology, 435(1). https://doi.org/10.1016/j.jmb.2022.167714

Ge, P., Dawson, V. L., & Dawson, T. M. (2020). PINK1 and Parkin mitochondrial quality control: A source of regional vulnerability in Parkinson’s disease. Molecular Neurodegeneration, 15(1), 20. https://doi.org/10.1186/s13024-020-00367-7

Article  PubMed  PubMed Central  Google Scholar 

German, C. L., Baladi, M. G., McFadden, L. M., Hanson, G. R., & Fleckenstein, A. E. (2015). Regulation of the dopamine and vesicular monoamine transporters: Pharmacological targets and implications for disease. Pharmacological Reviews, 67(4), 1005–1024. https://doi.org/10.1124/pr.114.010397

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grossmann, D., Berenguer-Escuder, C., Chemla, A., Arena, G., & Krüger, R. (2020). The emerging role of RHOT1/Miro1 in the pathogenesis of Parkinson’s disease. Frontiers in Neurology, 11, 587. https://doi.org/10.3389/fneur.2020.00587

Article  PubMed  PubMed Central  Google Scholar 

Ham, S. J., Lee, D., Yoo, H., & Chung, J. (2020). Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination. Proceedings of the National Academy of Sciences of the United States of America, 117(8), 4281–4291. https://doi.org/10.1073/pnas.1909814117

Article  CAS  PubMed  PubMed Central  Google Scholar