Alzheimer’s Disease Facts and Figures. Alzheimers Dement. 2024, 20: 3708–3821.

Article  Google Scholar 

Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med 2011, 1: a006189.

Article  PubMed  PubMed Central  Google Scholar 

Colombo E, Farina C. Astrocytes: Key regulators of neuroinflammation. Trends Immunol 2016, 37: 608–620.

Article  CAS  PubMed  Google Scholar 

Rodríguez-Arellano JJ, Parpura V, Zorec R, Verkhratsky A. Astrocytes in physiological aging and Alzheimer’s disease. Neuroscience 2016, 323: 170–182.

Article  PubMed  Google Scholar 

Jia YJ, Wang XY, Liu J, Wang YJ, Masters CL, Guo JH. Halting the progression of Alzheimer’s disease: Is the goal in sight? Neurosci Bull 2025, 41: 723–727.

Article  PubMed  Google Scholar 

Barres BA. The mystery and magic of Glia: A perspective on their roles in health and disease. Neuron 2008, 60: 430–440.

Article  CAS  PubMed  Google Scholar 

Sun Y, Yu H, Guan Y. Glia connect inflammation and neurodegeneration in multiple sclerosis. Neurosci Bull 2023, 39: 466–478.

Article  PubMed  PubMed Central  Google Scholar 

Santello M, Bezzi P, Volterra A. TNFα controls glutamatergic gliotransmission in the hippocampal dentate gyrus. Neuron 2011, 69: 988–1001.

Article  CAS  PubMed  Google Scholar 

Park CK, Lü N, Xu ZZ, Liu T, Serhan CN, Ji RR. Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J Neurosci 2011, 31: 15072–15085.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berta T, Park CK, Xu ZZ, Xie RG, Liu T, Lü N. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. J Clin Invest 2014, 124: 1173–1186.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci 2001, 2: 734–744.

Article  CAS  PubMed  Google Scholar 

Cheng X, Shen Y, Li R. Targeting TNF: A therapeutic strategy for Alzheimer’s disease. Drug Discov Today 2014, 19: 1822–1827.

Article  CAS  PubMed  Google Scholar 

Miao X, Huang Y, Liu TT, Guo R, Wang B, Wang XL, et al. TNF-α/TNFR1 signaling is required for the full expression of acute and chronic itch in mice via peripheral and central mechanisms. Neurosci Bull 2018, 34: 42–53.

Article  CAS  PubMed  Google Scholar 

Kalliolias GD, Ivashkiv LB. TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat Rev Rheumatol 2016, 12: 49–62.

Article  CAS  PubMed  Google Scholar 

He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, et al. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer’s mice. J Cell Biol 2007, 178: 829–841.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang H, He P, Xie J, Staufenbiel M, Li R, Shen Y. Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα. Hum Mol Genet 2014, 23: 4906–4918.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel JR, Williams JL, Muccigrosso MM, Liu L, Sun T, Rubin JB, et al. Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS. Acta Neuropathol 2012, 124: 847–860.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao H, Danzi MC, Choi CS, Taherian M, Dalby-Hansen C, Ellman DG, et al. Opposing functions of microglial and macrophagic TNFR2 in the pathogenesis of experimental autoimmune encephalomyelitis. Cell Rep 2017, 18: 198–212.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fischer R, Wajant H, Kontermann R, Pfizenmaier K, Maier O. Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor. Glia 2014, 62: 272–283.

Article  PubMed  Google Scholar 

Madsen PM, Motti D, Karmally S, Szymkowski DE, Lambertsen KL, Bethea JR, et al. Oligodendroglial TNFR2 mediates membrane TNF-dependent repair in experimental autoimmune encephalomyelitis by promoting oligodendrocyte differentiation and remyelination. J Neurosci 2016, 36: 5128–5143.

Article  PubMed  PubMed Central  Google Scholar 

Cheng X, Yang L, He P, Li R, Shen Y. Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer’s disease and non-demented patients. J Alzheimers Dis 2010, 19: 621–630.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng X, He P, Yao H, Dong Q, Li R, Shen Y. Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy. Neurology 2014, 82: 1707–1715.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, et al. APP mouse models for Alzheimer’s disease preclinical studies. EMBO J 2017, 36: 2473–2487.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masuda A, Kobayashi Y, Kogo N, Saito T, Saido TC, Itohara S. Cognitive deficits in single App knock-in mouse models. Neurobiol Learn Mem 2016, 135: 73–82.

Article  CAS  PubMed  Google Scholar 

Youmans KL, Leung S, Zhang J, Maus E, Baysac K, Bu G, et al. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. J Neurosci Methods 2011, 196: 51–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, et al. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res 2004, 32: D258–D261.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S. Eigengene networks for studying the relationships between co-expression modules. BMC Syst Biol 2007, 1: 54.

Article  PubMed  PubMed Central  Google Scholar 

Schildge S, Bohrer C, Beck K, Schachtrup C. Isolation and culture of mouse cortical astrocytes. J Vis Exp 2013: 50079.

Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, et al. Single App knock-in mouse models of Alzheimer’s disease. Nat Neurosci 2014, 17: 661–663.

Article  CAS  PubMed  Google Scholar 

Sharma A, Kazim SF, Larson CS, Ramakrishnan A, Gray JD, McEwen BS, et al. Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures. Proc Natl Acad Sci U S A 2019, 116: 21800–21811.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenfeld CS, Ferguson SA. Barnes maze testing strategies with small and large rodent models. J Vis Exp 2014: e51194.

Lueptow LM. Novel object recognition test for the investigation of learning and memory in mice. J Vis Exp 2017: 55718.

Horikoshi Y, Sakaguchi G, Becker AG, Gray AJ, Duff K, Aisen PS, et al. Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun 2004, 319: 733–737.