Time-dependent diffusion MRI for non-invasive differentiation of benign and malignant breast lesions and evaluation of proliferation index biomarkers

Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA, Minihan A, et al. Breast cancer statistics, 2022. CA Cancer J Clin. 2022;72:524–41.

PubMed  Google Scholar 

Liu J, Zhao H, Huang Y, Xu S, Zhou Y, Zhang W, et al. Genome-wide cell-free DNA methylation analyses improve accuracy of non-invasive diagnostic imaging for early-stage breast cancer. Mol Cancer. 2021;20:36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strigel RM, Burnside ES, Elezaby M, Fowler AM, Kelcz F, Salkowski LR, et al. Utility of BI-RADS assessment category 4 subdivisions for screening breast MRI. AJR Am J Roentgenol. 2017;208:1392–9.

Article  PubMed  PubMed Central  Google Scholar 

Wekking D, Porcu M, De Silva P, Saba L, Scartozzi M, Solinas C. Breast MRI: clinical indications, recommendations, and future applications in breast cancer diagnosis. Curr Oncol Rep. 2023;25:257–67.

Article  PubMed  Google Scholar 

Behzadi AH, Zhao Y, Farooq Z, Prince MR. Immediate allergic reactions to gadolinium-based contrast agents: a systematic review and meta-analysis. Radiology. 2018;286:731.

Article  PubMed  Google Scholar 

Amornsiripanitch N, Bickelhaupt S, Shin HJ, Dang M, Rahbar H, Pinker K, et al. Diffusion-weighted MRI for unenhanced breast cancer screening. Radiology. 2019;293:504–20.

Article  PubMed  PubMed Central  Google Scholar 

Zhao M, Pipe JG, Bonnett J, Evelhoch JL. Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo. Br J Cancer. 1996;73:61–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sugahara T, Korogi Y, Kochi M, Ikushima I, Shigematu Y, Hirai T, et al. Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging. 1999;9:53–60.

Article  CAS  PubMed  Google Scholar 

Gauvain KM, McKinstry RC, Mukherjee P, Perry A, Neil JJ, Kaufman BA, et al. Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR Am J Roentgenol. 2001;177:449–54.

Article  CAS  PubMed  Google Scholar 

Kazama T, Takahara T, Hashimoto J. Breast cancer subtypes and quantitative magnetic resonance imaging: a systemic review. Life. 2022. https://doi.org/10.3390/life12040490.

Article  PubMed  PubMed Central  Google Scholar 

Cory DG, Garroway AN. Measurement of translational displacement probabilities by NMR: an indicator of compartmentation. Magn Reson Med. 1990;14:435–44.

Article  CAS  PubMed  Google Scholar 

Szafer A, Zhong J, Gore JC. Theoretical model for water diffusion in tissues. Magn Reson Med. 1995;33:697–712.

Article  CAS  PubMed  Google Scholar 

van der Toorn A, Syková E, Dijkhuizen RM, Vorísek I, Vargová L, Skobisová E, et al. Dynamic changes in water ADC, energy metabolism, extracellular space volume, and tortuosity in neonatal rat brain during global ischemia. Magn Reson Med. 1996;36:52–60.

Article  PubMed  Google Scholar 

Padhani AR, Liu G, Koh DM, Chenevert TL, Thoeny HC, Takahara T, et al. Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia. 2009;11:102–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoshikawa MI, Ohsumi S, Sugata S, Kataoka M, Takashima S, Mochizuki T, et al. Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer. Radiat Med. 2008;26:222–6.

Article  PubMed  Google Scholar 

Squillaci E, Manenti G, Cova M, Di Roma M, Miano R, Palmieri G, et al. Correlation of diffusion-weighted MR imaging with cellularity of renal tumours. Anticancer Res. 2004;24:4175–9.

PubMed  Google Scholar 

Zhang H, Liu K, Ba R, Zhang Z, Zhang Y, Chen Y, et al. Histological and molecular classifications of pediatric glioma with time-dependent diffusion MRI-based microstructural mapping. Neuro Oncol. 2023;25:1146–56.

Article  PubMed  PubMed Central  Google Scholar 

Hoffmann E, Gerwing M, Niland S, Niehoff R, Masthoff M, Geyer C, et al. Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI. J Immunother Cancer. 2023. https://doi.org/10.1136/jitc-2022-006092.

Article  PubMed  PubMed Central  Google Scholar 

Ba R, Wang X, Zhang Z, Li Q, Sun Y, Zhang J, et al. Diffusion-time dependent diffusion MRI: effect of diffusion-time on microstructural mapping and prediction of prognostic features in breast cancer. Eur Radiol. 2023;33:6226–37.

Article  CAS  PubMed  Google Scholar 

Jiang X, Li H, Xie J, Zhao P, Gore JC, Xu J. Quantification of cell size using temporal diffusion spectroscopy. Magn Reson Med. 2016;75:1076–85.

Article  PubMed  Google Scholar 

Jiang X, Li H, Xie J, McKinley ET, Zhao P, Gore JC, et al. In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy. Magn Reson Med. 2017;78:156–64.

Article  CAS  PubMed  Google Scholar 

Liu K, Lin Z, Zheng T, Ba R, Zhang Z, Li H, et al. Improving microstructural estimation in time-dependent diffusion MRI with a Bayesian method. J Magn Reson Imaging. 2025;61:724–34.

Article  PubMed  Google Scholar 

Luporsi E, André F, Spyratos F, Martin PM, Jacquemier J, Penault-Llorca F, et al. Ki-67: level of evidence and methodological considerations for its role in the clinical management of breast cancer: analytical and critical review. Breast Cancer Res Treat. 2012;132:895–915.

Article  CAS  PubMed  Google Scholar 

Davey MG, Hynes SO, Kerin MJ, Miller N, Lowery AJ. Ki-67 as a prognostic biomarker in invasive breast cancer. Cancers (Basel). 2021. https://doi.org/10.3390/cancers13174455.

Article  PubMed  PubMed Central  Google Scholar 

Soliman NA, Yussif SM. Ki-67 as a prognostic marker according to breast cancer molecular subtype. Cancer Biol Med. 2016;13:496–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Jiang X, Li H, Arlinghaus LR, McKinley ET, Devan SP, et al. Magnetic resonance imaging of mean cell size in human breast tumors. Magn Reson Med. 2020;83:2002–14.

Article  PubMed  Google Scholar 

Wang X, Huang Y, Cao Y, Chen H, Gong X, Lan X, et al. Time-dependent diffusion MRI-based microstructural mapping for characterizing HER2-Zero, -Low, -Ultra-Low, and -Positive breast cancer. J Magn Reson Imaging. 2025;62:1754–67.

Article  PubMed  Google Scholar 

Li X, Yi Y, Wu Y, Hua B, Jiang L, Chen M. Conventional, time-dependent, and continuous-time random-walk diffusion-weighted imaging models in microstructural characterization of breast lesions at 3.0 T: a prospective analysis. Med Phys. 2025;52:e17960.

Article  CAS  PubMed  Google Scholar 

Wu D, Jiang K, Li H, Zhang Z, Ba R, Zhang Y, et al. Time-dependent diffusion MRI for quantitative microstructural mapping of prostate cancer. Radiology. 2022;303:578–87.

Article  PubMed  Google Scholar 

Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol. 2013;24:2206–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, et al. Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015. Ann Oncol. 2015;26:1533–46.

Article  CAS  PubMed  PubMed Central 

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