Braekeleer M, Tous C, Guéganic N, Le Bris MJ, Basinko A, Morel F, et al. Immunoglobulin gene translocations in chronic lymphocytic leukemia: a report of 35 patients and review of the literature. Mol Clin Oncol. 2016;4:682–94.

Article  PubMed  PubMed Central  Google Scholar 

Nagel I, Szczepanowski M, Martín-Subero JI, Harder L, Akasaka T, Ammerpohl O, et al. Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies. Blood. 2010;116:1317–20.

Article  CAS  PubMed  Google Scholar 

Siebert R, Rosenwald A, Staudt LM, Morris SW. Molecular features of B-cell lymphoma. Curr Opin Oncol. 2001;13:316–24.

Article  CAS  PubMed  Google Scholar 

Dyer MJS, Akasaka T, Capasso M, Dusanjh P, Lee YF, Karran EL, et al. Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers? Blood. 2010;115:1490–9.

Article  CAS  PubMed  Google Scholar 

Boxer LM, Dang CV. Translocations involving c-myc and c-myc function. Oncogene. 2001;20:5595–610.

Article  CAS  PubMed  Google Scholar 

Hecht JL, Aster JC. Molecular biology of Burkitt’s lymphoma. J Clin Oncol. 2000;18:3707–21.

Article  CAS  PubMed  Google Scholar 

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th edition. Lyon: International Agency for Research on Cancer; 2017. 585 p. (World Health Organization classification of tumours).

Ueshima Y, Haren JM, Bird ML, Rowley JD. Culture conditions in chronic lymphocytic leukemia: relationship to karyotype. Leukemia. 1989;3:192–4.

CAS  PubMed  Google Scholar 

Baliakas P, Espinet B, Mellink C, Jarosova M, Athanasiadou A, Ghia P, et al. Cytogenetics in chronic lymphocytic leukemia: ERIC perspectives and recommendations. Hemasphere. 2022;6:e707.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Decker T, Schneller F, Kronschnabl M, Dechow T, Lipford GB, Wagner H, et al. Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: Costimulation with IL-2 results in a highly immunogenic phenotype. Exp Hematol. 2000;28:558–68.

Article  CAS  PubMed  Google Scholar 

Dicker F, Schnittger S, Haferlach T, Kern W, Schoch C. Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: A study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expression. Blood. 2006;108:3152–60.

Article  CAS  PubMed  Google Scholar 

Put N, Konings P, Rack K, Jamar M, Roy NV, Libouton JM, et al. Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study. Genes, Chromosomes Cancer. 2009;48:843–53.

Article  CAS  PubMed  Google Scholar 

Takashima T, Itoh M, Ueda Y, Nishida K, Tamaki T, Misawa S, et al. Detection of 14q32.33 translocation and t(11;14) in interphase nuclei of chronic B-cell leukemia/lymphomas by in situ hybridization. Int J Cancer. 1997;72:31–8.

Article  CAS  PubMed  Google Scholar 

Fang H, Reichard KK, Rabe KG, Hanson CA, Call TG, Ding W, et al. IGH translocations in chronic lymphocytic leukemia: Clinicopathologic features and clinical outcomes. Am J Hematol. 2019;94:338–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen-Khac F, Chapiro E, Lesty C, Grelier A, Luquet I, Radford-Weiss I, et al. Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia. Am J Blood Res. 2011;1:13–21.

CAS  PubMed  PubMed Central  Google Scholar 

Heerema NA, Muthusamy N, Zhao Q, Ruppert AS, Breidenbach H, Andritsos LA, et al. Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia. Haematologica. 2021;106:1608–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martín-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia. 2007;21:1532–44.

Article  PubMed  Google Scholar 

Giefing M, Siebert R. FISH and FICTION to detect chromosomal aberrations in lymphomas. Methods Mol Biol. 2013;971:227–44.

Article  CAS  PubMed  Google Scholar 

Ventura RA, Martin-Subero JI, Jones M, McParland J, Gesk S, Mason DY, et al. FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffin-embedded tissue. J Mol Diagn. 2006;8:141–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, et al. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021;35:2002–16.

Article  PubMed  PubMed Central  Google Scholar 

Tausch E, Schneider C, Robrecht S, Zhang C, Dolnik A, Bloehdorn J, et al. Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax. Blood. 2020;135:2402–12.

Article  PubMed  Google Scholar 

Knisbacher BA, Lin Z, Hahn CK, Nadeu F, Duran-Ferrer M, Stevenson KE, et al. Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genetics. 2022;54:1664–74.

Tausch E, Beck P, Schlenk RF, Jebaraj BJ, Dolnik A, Yosifov DY, et al. Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1. haematol. 2020;105:2440–7.

Article  CAS  Google Scholar 

Kröber A, Seiler T, Benner A, Bullinger L, Brückle E, Lichter P, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 2002;100:1410–6.

Article  PubMed  Google Scholar 

Jaramillo S, Agathangelidis A, Schneider C, Bahlo J, Robrecht S, Tausch E, et al. Prognostic impact of prevalent chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group (GCLLSG). haematol. 2020;105:2598–607.

Article  CAS  Google Scholar 

Massoni-Badosa R, Aguilar-Fernández S, Nieto JC, Soler-Vila P, Elosua-Bayes M, Marchese D, et al. An atlas of cells in the human tonsil. Immunity. 2024;57:379–99.e18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossi D, Gaidano G. Biological and clinical significance of stereotyped B-cell receptors in chronic lymphocytic leukemia. haematol. 2010;95:1992–5.

Article  CAS  Google Scholar 

Kushwaha G, Dozmorov M, Wren JD, Qiu J, Shi H, Xu D. Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia. Hum Genomics. 2016;10:18.

Article  PubMed  PubMed Central  Google Scholar 

Asirvatham JR, Brody J, Vora R, Kolitz JE, Fields SZ, Sreekantaiah C, et al. Prognostic significance of isolated t(8:14) in chronic lymphocytic leukemia. Leuk Lymphoma. 2014;55:685–8.

Article  PubMed  Google Scholar 

Huh YO, Lin KIC, Vega F, Schlette E, Yin CC, Keating MJ, et al. MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis. Br J Haematol. 2008;142:36–44.

Article  PubMed  Google Scholar 

Put N, Van Roosbroeck K, Konings P, Meeus P, Brusselmans C, Rack K, et al. Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course. Ann Hematol. 2012;91:863–73.

Article  CAS  PubMed  Google Scholar 

Roco JA, Mesin L, Binder SC, Nefzger C, Gonzalez-Figueroa P, Canete PF, et al. Class-switch recombination occurs infrequently in germinal centers. Immunity. 2019;51:337–50.e7.

Article  CAS  PubMed