Nemeth, K., Bayraktar, R., Ferracin, M. & Calin, G. A. Non-coding RNAs in disease: from mechanisms to therapeutics. Nat. Rev. Genet. 25, 211––232 (2024).

Article  PubMed  Google Scholar 

Vargas, A. J. & Harris, C. C. Biomarker development in the precision medicine era: lung cancer as a case study. Nat. Rev. Cancer 16, 525–537 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Therriault, J. et al. Biomarker-based staging of Alzheimer disease: rationale and clinical applications. Nat. Rev. Neurol. 20, 232–244 (2024).

Article  PubMed  Google Scholar 

Mattsson-Carlgren, N. et al. Plasma biomarker strategy for selecting patients with Alzheimer disease for antiamyloid immunotherapies. JAMA Neurol. 81, 69–78 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Jung, G., Hernández-Illán, E., Moreira, L., Balaguer, F. & Goel, A. Epigenetics of colorectal cancer: biomarker and therapeutic potential. Nat. Rev. Gastroenterol. Hepatol. 17, 111–130 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Hansson, O. Biomarkers for neurodegenerative diseases. Nat. Med. 27, 954–963 (2021).

Article  CAS  PubMed  Google Scholar 

Omalu, B., Diu, S., Paudel, N., Parson, S. J. & Hammers, J. L. autopsy cardiac troponin I plasma levels can be elevated in myocardial infarction type 3: a proposal to modify the definition of myocardial infarction type 3. Am. J. Forensic Med. Pathol. 42, 225–229 (2021).

Article  PubMed  Google Scholar 

Masud, M. K. et al. Superparamagnetic nanoarchitectures for disease-specific biomarker detection. Chem. Soc. Rev. 48, 5717–5751 (2019).

Article  CAS  PubMed  Google Scholar 

Yaari, Z. et al. A perception-based nanosensor platform to detect cancer biomarkers. Sci. Adv. 7, eabj0852 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Romeo, M. V., López-Martínez, E., Berganza-Granda, J., Goñi-de-Cerio, F. & Cortajarena, A. L. Biomarker sensing platforms based on fluorescent metal nanoclusters. Nanoscale Adv. 3, 1331–1341 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ming, J., Xie, Z., Wu, J. & Zhang, F. Synthesis of transition metal-sensitized lanthanide near-infrared luminescent nanoparticles. Nat. Protoc. 10.1038/s41596-025-01245-6 (2025).

Xie, W. et al. Synthesis of ordered mesoporous metal oxides by solvent evaporation-induced cooperative assembly. Nat. Protoc. 21, 987–1020 (2025).

Article  PubMed  Google Scholar 

Castro, R. C., Ribeiro, D. S. & Santos, J. L. Visual detection using quantum dots sensing platforms. Coord. Chem. Rev. 429, 213637 (2021).

Article  CAS  Google Scholar 

Gao, L. et al. Fluorescent probes for bioimaging of potential biomarkers in Parkinson’s disease. Chem. Soc. Rev. 50, 1219–1250 (2021).

Article  CAS  PubMed  Google Scholar 

Li, G., Liu, Z., Gao, W. & Tang, B. Recent advancement in graphene quantum dots based fluorescent sensor: design, construction and bio-medical applications. Coord. Chem. Rev. 478, 214966 (2023).

Article  CAS  Google Scholar 

Wei, J., Zhang, X., Mugo, S. M. & Zhang, Q. A portable sweat sensor based on carbon quantum dots for multiplex detection of cardiovascular health biomarkers. Anal. Chem. 94, 12772–12780 (2022).

Article  CAS  PubMed  Google Scholar 

Chen, C., Zhang, X., Gao, Z., Feng, G. & Ding, D. Preparation of AIEgen-based near-infrared afterglow luminescence nanoprobes for tumor imaging and image-guided tumor resection. Nat. Protoc. 19, 2408–2434 (2024).

Article  CAS  PubMed  Google Scholar 

Han, Z., Wang, K., Zhou, H.-C., Cheng, P. & Shi, W. Preparation and quantitative analysis of multicenter luminescence materials for sensing function. Nat. Protoc. 18, 1621–1640 (2023).

Article  CAS  PubMed  Google Scholar 

Jung, C. et al. Disordered-nanoparticle-based etalon for ultrafast humidity-responsive colorimetric sensors and anti-counterfeiting displays. Sci. Adv. 8, eabm8598 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Picci, G., Montis, R., Gilchrist, A. M., Gale, P. A. & Caltagirone, C. Fluorescent and colorimetric sensors for anions: highlights from 2020 to 2022. Coord. Chem. Rev. 501, 215561 (2024).

Article  CAS  Google Scholar 

Qin, M., Li, J. & Song, Y. Toward high sensitivity: perspective on colorimetric photonic crystal sensors. Anal. Chem. 94, 9497–9507 (2022).

Article  CAS  PubMed  Google Scholar 

Yang, X. L. et al. Chiral MOF derived wearable logic sensor for intuitive discrimination of physiologically active enantiomer. Adv. Mater. 35, 2304046 (2023).

Article  CAS  Google Scholar 

Quan, M., Pang, X. Y. & Jiang, W. Circular dichroism based chirality sensing with supramolecular host–guest chemistry. Angew. Chem. Int. Ed. 134, e202201258 (2022).

Article  Google Scholar 

Li, D. et al. Chiral bimetallic Pt@Au octapods with spiral four-petal flower-like symmetric configuration as sensitive SERS probes. Angew. Chem. Int. Ed. 64, e202501894 (2025).

Article  CAS  Google Scholar 

Kim, R. M. et al. Enantioselective sensing by collective circular dichroism. Nature 612, 470–476 (2022).

Article  CAS  PubMed  Google Scholar 

Hao, C. et al. Chiral gold nanostructure monolayers as SERS substrates for ultrasensitive detection of enantiomer biomarkers of Alzheimer’s disease. Angew. Chem. Int. Ed. 64, e202502115 (2025).

Article  CAS  Google Scholar 

Dai, J. et al. A telomerase-activated magnetic resonance imaging probe for consecutively monitoring tumor growth kinetics and in situ screening inhibitors. J. Am. Chem. Soc. 145, 1108–1117 (2023).

Article  CAS  PubMed  Google Scholar 

Chen, B. et al. Stimuli-responsive switchable MRI nanoprobe for tumor theranostics. Nano Today 51, 101931 (2023).

Article  CAS  Google Scholar 

Allouche-Arnon, H. et al. Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression. Nat. Biotechnol. 40, 1143–1149 (2022).

Article  CAS  PubMed  Google Scholar 

Cheng, W. et al. Asymmetrically split DNAzyme-based colorimetric and electrochemical dual-modal biosensor for detection of breast cancer exosomal surface proteins. Biosens. Bioelectron. 238, 115552 (2023).

Article  CAS  PubMed  Google Scholar 

Zhou, Y. et al. Recent advances in colorimetry/fluorimetry-based dual-modal sensing technologies. Biosens. Bioelectron. 190, 113386 (2021).

Article  CAS  PubMed  Google Scholar 

Wen, S.-H. et al. Complementary homogeneous electrochemical and photothermal dual-modal sensor for highly sensitive detection of organophosphorus pesticides via stimuli-responsive COF/methylene blue@ MnO2 composite. Anal. Chem. 95, 14914–14924 (2023).

Article  CAS  PubMed  Google Scholar 

Wang, Y., Hu, Y. & Ye, D. Activatable multimodal probes for in vivo imaging and theranostics. Angew. Chem. Int. Ed. 134, e202209512 (2022).

Article  Google Scholar 

Wang, S. et al. An organic electrochemical transistor for multi-modal sensing, memory and processing. Nat. Electron. 6, 281–291 (2023).

Article  CAS  Google Scholar 

Liu, R. et al. Precisely detecting the telomerase activities by an AIEgen probe with dual signal outputs after cell-cycle synchronization. Anal. Chem. 94, 4874–4880 (2022).