Christensen, C. et al. Diet, food, and nutritional exposures and inflammatory bowel disease or progression of disease: an umbrella review. Adv. Nutr. 15, 100219 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, J. et al. Dietary antioxidant capacity, genetic susceptibility and polymorphism, and inflammatory bowel disease risk in a prospective cohort. Clin. Gastroenterol. Hepatol. https://doi.org/10.1016/j.cgh.2024.09.033 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Han, T. et al. The future landscape and framework of precision nutrition. Engineering 42, 15–25 (2024).

Article  CAS  Google Scholar 

Petermann, I. et al. Mushroom intolerance: a novel diet-gene interaction in Crohn’s disease. Br. J. Nutr. 102, 506–508 (2009).

Article  CAS  PubMed  Google Scholar 

Ananthakrishnan, A. N. et al. Genetic polymorphisms in fatty acid metabolism modify the association between dietary n3: n6 intake and risk of ulcerative colitis: a prospective cohort study. Inflamm. Bowel Dis. 23, 1898–1904 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Levine, A. et al. Dietary guidance from the International Organization for the Study of Inflammatory Bowel Diseases. Clin. Gastroenterol. Hepatol. 18, 1381–1392 (2020).

Article  PubMed  Google Scholar 

Heaton, K. W., Thornton, J. R. & Emmett, P. M. Treatment of Crohn’s disease with an unrefined-carbohydrate, fibre-rich diet. Br. Med. J. 2, 764–766 (1979).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hashash, J. G., Elkins, J., Lewis, J. D. & Binion, D. G. AGA clinical practice update on diet and nutritional therapies in patients with inflammatory bowel disease: expert review. Gastroenterology 166, 521–532 (2024).

Article  CAS  PubMed  Google Scholar 

Svolos, V. et al. European Crohn's and Colitis Organisation consensus on dietary management of inflammatory bowel disease. J. Crohns Colitis. 19, jjaf122 (2025).

Article  PubMed  Google Scholar 

Cuparencu, C. et al. Towards nutrition with precision: unlocking biomarkers as dietary assessment tools. Nat. Metab. 6, 1438–1453 (2024).

Article  PubMed  Google Scholar 

Sasson, A. N. et al. The role of precision nutrition in the modulation of microbial composition and function in people with inflammatory bowel disease. Lancet Gastroenterol. Hepatol. 6, 754–769 (2021).

Article  PubMed  Google Scholar 

Lee, B. Y. et al. Research gaps and opportunities in precision nutrition: an NIH workshop report. Am. J. Clin. Nutr. 116, 1877–1900 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bush, C. L. et al. Toward the definition of personalized nutrition: a proposal by the American Nutrition Association. J. Am. Coll. Nutr. 39, 5–15 (2020).

Article  PubMed  Google Scholar 

Zeisel, S. H. Precision (personalized) nutrition: understanding metabolic heterogeneity. Annu. Rev. Food Sci. Technol. 11, 71–92 (2020).

Article  PubMed  Google Scholar 

Gibney, M. J. & Walsh, M. C. The future direction of personalised nutrition: my diet, my phenotype, my genes. Proc. Nutr. Soc. 72, 219–225 (2013).

Article  PubMed  Google Scholar 

Ferguson, L. R. et al. Guide and position of the International Society of Nutrigenetics/Nutrigenomics on personalised nutrition: Part 1 - Fields of precision nutrition. J. Nutrigenet Nutrigenomics 9, 12–27 (2016).

PubMed  Google Scholar 

Ben-Yacov, O. et al. Personalized postprandial glucose response — targeting diet versus Mediterranean diet for glycemic control in prediabetes. Diabetes Care 44, 1980–1991 (2021).

Article  CAS  PubMed  Google Scholar 

Bermingham, K. M. et al. Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nat. Med. 30, 1888–1897 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berry, S. E. et al. Human postprandial responses to food and potential for precision nutrition. Nat. Med. 26, 964–973 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeevi, D. et al. Personalized nutrition by prediction of glycemic responses. Cell 163, 1079–1094 (2015).

Article  CAS  PubMed  Google Scholar 

Downs, S. M., Ahmed, S., Fanzo, J. & Herforth, A. Food environment typology: advancing an expanded definition, framework, and methodological approach for improved characterization of wild, cultivated, and built food environments toward sustainable diets. Foods 9, 532 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Chhibba, T. et al. Environmental risk factors of inflammatory bowel disease: toward a strategy of preventative health. J. Crohns Colitis 19, jjaf042 (2025).

Article  PubMed  PubMed Central  Google Scholar 

Guo, A. et al. Early-life diet and risk of inflammatory bowel disease: a pooled study in two Scandinavian birth cohorts. Gut 73, 590–600 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Khalili, H. et al. Diet quality and risk of older-onset Crohn’s disease and ulcerative colitis. J. Crohns Colitis 17, 746–753 (2023).

Article  PubMed  Google Scholar 

Khalili, H. et al. Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn’s disease: results from two large prospective cohort studies. Gut 69, 1637–1644 (2020).

Article  PubMed  Google Scholar 

Chen, J. et al. Composition of plant-based diets and the incidence and prognosis of inflammatory bowel disease: a multinational retrospective cohort study. Lancet Reg. Health Eur. 52, 101264 (2025).

Article  PubMed  PubMed Central  Google Scholar 

Chen, J. et al. Intake of ultra-processed foods is associated with an increased risk of Crohn’s disease: a cross-sectional and prospective analysis of 187 154 participants in the UK Biobank. J. Crohns Colitis 17, 535–552 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Lopes, E. W. et al. Lifestyle factors for the prevention of inflammatory bowel disease. Gut https://doi.org/10.1136/gutjnl-2022-328174 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Powe, C. E. et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N. Engl. J. Med. 369, 1991–2000 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Y. et al. Serum 25-hydroxyvitamin D, type 2 diabetes, and liver-related outcomes: secondary data analysis of a prospective recruited cohort. Hepatol. Commun. 7, e0291 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Ananthakrishnan, A. N. et al. Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn’s disease. Inflamm. Bowel Dis. 19, 1921–1927 (2013).

PubMed  PubMed Central  Google Scholar 

Dan, L. et al. Circulating 25-hydroxyvitamin D concentration can predict bowel resection risk among individuals with inflammatory bowel disease in a longitudinal cohort with 13 years of follow-up. Int. J. Surg. 110, 4275–4285 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Armstrong, H. K. et al. Unfermented β-fructan fiber