Understanding development and cellular plasticity in the pancreas in health and disease

Sáez, M., Briscoe, J. & Rand, D. A. Dynamical landscapes of cell fate decisions. Interface Focus 12, 20220002 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Tata, A., Chow, R. D. & Tata, P. R. Epithelial cell plasticity: breaking boundaries and changing landscapes. EMBO Rep. 22, e51921 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin, X. & Tape, C. J. Functional analysis of cell plasticity using single-cell technologies. Trends Cell Biol. 34, 854–864 (2024).

Article  CAS  PubMed  Google Scholar 

Torborg, S. R., Li, Z., Chan, J. E. & Tammela, T. Cellular and molecular mechanisms of plasticity in cancer. Trends Cancer 8, 735–746 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shyer, A. E. & Rodrigues, A. R. Transcending the hegemony of the molecular machine through an organic renewal of biology and biomedicine. Cells Dev. 184, 204018 (2025).

Article  CAS  PubMed  Google Scholar 

Ahuja, N. & Cleaver, O. The cell cortex as mediator of pancreatic epithelial development and endocrine differentiation. Curr. Opin. Genet. Dev. 72, 118–127 (2022).

Article  CAS  PubMed  Google Scholar 

Gutierrez, G. D., Gromada, J. & Sussel, L. Heterogeneity of the pancreatic beta cell. Front. Genet. 8, 22 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Larsen, H. L. & Grapin-Botton, A. The molecular and morphogenetic basis of pancreas organogenesis. Semin. Cell Dev. Biol. 66, 51–68 (2017).

Article  CAS  PubMed  Google Scholar 

Pan, F. C. & Wright, C. Pancreas organogenesis: from bud to plexus to gland. Dev. Dyn. 240, 530–565 (2011).

Article  CAS  PubMed  Google Scholar 

Sakhneny, L., Khalifa-Malka, L. & Landsman, L. Pancreas organogenesis: approaches to elucidate the role of epithelial-mesenchymal interactions. Semin. Cell Dev. Biol. 92, 89–96 (2019).

Article  CAS  PubMed  Google Scholar 

Zorn, A. M. & Wells, J. M. Vertebrate endoderm development and organ formation. Annu. Rev. Cell Dev. Biol. 25, 221–251 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nowotschin, S. et al. The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature 569, 361–367 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, K.-R. et al. Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution. Cell 188, 796–813.e24 (2025).

Article  CAS  PubMed  Google Scholar 

Willnow, D. et al. Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche. Nature 597, 87–91 (2021).

Article  CAS  PubMed  Google Scholar 

Weinreb, C., Rodriguez-Fraticelli, A., Camargo, F. D. & Klein, A. M. Lineage tracing on transcriptional landscapes links state to fate during differentiation. Science 367, eaaw3381 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel, S. H. et al. Lifelong multilineage contribution by embryonic-born blood progenitors. Nature 606, 747–753 (2022).

Article  CAS  PubMed  Google Scholar 

Mizeracka, K. et al. Lineage-specific control of convergent differentiation by a Forkhead repressor. Development 148, dev199493 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inge, O. C. K. et al. Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation. Dev. Cell 60, 3304–3320.e9 (2025).

Article  CAS  PubMed  Google Scholar 

D’Amato, G. et al. Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4. Dev. Cell 57, 2517–2532.e6 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Ma, Z. et al. Deciphering early human pancreas development at the single-cell level. Nat. Commun. 14, 5354 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koike, H. et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary. Nature 574, 112–116 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong, Y. F. et al. Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation. Nat. Cell Biol. 25, 481–492 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deutsch, G., Jung, J., Zheng, M., Lóra, J. & Zaret, K. S. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128, 871–881 (2001).

Article  CAS  PubMed  Google Scholar 

Serls, A. E., Doherty, S., Parvatiyar, P., Wells, J. M. & Deutsch, G. H. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132, 35–47 (2005).

Article  CAS  PubMed  Google Scholar 

Xiao, L., Fan, D., Qi, H., Cong, Y. & Du, Z. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Cell Syst. 13, 615–630.e9 (2022).

Article  CAS  PubMed  Google Scholar 

Bort, R., Martinez-Barbera, J. P., Beddington, R. S. P. & Zaret, K. S. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 131, 797–806 (2004).

Article  CAS  PubMed  Google Scholar 

Stanger, B. Z., Tanaka, A. J. & Melton, D. A. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445, 886–891 (2007).

Article  CAS  PubMed  Google Scholar 

Harrison, K. A., Thaler, J., Pfaff, S. L., Gu, H. & Kehrl, J. H. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat. Genet. 23, 71–75 (1999).

Article  CAS  PubMed  Google Scholar 

Li, H., Arber, S., Jessell, T. M. & Edlund, H. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat. Genet. 23, 67–70 (1999).

Article  CAS  PubMed  Google Scholar 

Rodríguez-Seguel, E. et al. Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence. Genes Dev. 27, 1932–1946 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Jennings, R. E., Berry, A. A., Strutt, J. P., Gerrard, D. T. & Hanley, N. A. Human pancreas development. Development 142, 3126–3137 (2015).

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