G.M. Keserü, G.M. Makara. The influence of lead discovery strategies on the properties of drug candidates. Nature Reviews Drug Discovery 8 (2009) 203-212. https://doi.org/10.1038/nrd2796 DOI: https://doi.org/10.1038/nrd2796
[2] N. Blagden, M. de Matas, P.T. Gavan, P. York. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews 59 (2007) 617-630. https://doi.org/10.1016/j.addr.2007.05.011 DOI: https://doi.org/10.1016/j.addr.2007.05.011
[3] S.B.N. Agostini, B.A. Borges, M.B. De Araújo, R. Bonfilio. Growing Interest in Pharmaceutical Cocrystals: A Comprehensive Review of Applications and Trends. ChemistrySelect 10 (2025) e00831. https://doi.org/10.1002/slct.202500831 DOI: https://doi.org/10.1002/slct.202500831
[4] M. Omori, T. Watanabe, T. Uekusa, J. Oki, D. Inoue, K. Sugano. Effects of Coformer and Polymer on Particle Surface Solution-Mediated Phase Transformation of Cocrystals in Aqueous Media. Molecular Pharmaceutics 17 (2020) 3825-3836. https://doi.org/10.1021/acs.molpharmaceut.0c00587 DOI: https://doi.org/10.1021/acs.molpharmaceut.0c00587
[5] M. Omori, H. Yamamoto, F. Matsui, K. Sugano. Dissolution Profiles of Carbamazepine Cocrystals with Cis-Trans Isomeric Coformers. Pharmaceutical Research 40 (2023) 579-591. https://doi.org/10.1007/s11095-022-03209-x DOI: https://doi.org/10.1007/s11095-022-03209-x
[6] M. Shigemura, M. Omori, K. Sugano. Polymeric precipitation inhibitor differently affects cocrystal surface and bulk solution phase transformations. Journal of Drug Delivery Science and Technology (2021) 103029. https://doi.org/10.1016/j.jddst.2021.103029 DOI: https://doi.org/10.1016/j.jddst.2021.103029
[7] A. Beig, D. Lindley, J.M. Miller, R. Agbaria, A. Dahan. Hydrotropic solubilization of lipophilic drugs for oral delivery: the effects of urea and nicotinamide on carbamazepine solubility-permeability interplay. Frontiers in Pharmacology 7 (2016) 379. https://doi.org/10.3389/fphar.2016.00379 DOI: https://doi.org/10.3389/fphar.2016.00379
[8] M. Li, S. Qiu, Y. Lu, K. Wang, X. Lai, M. Rehan. Investigation of the effect of hydroxypropyl methylcellulose on the phase transformation and release profiles of carbamazepine-nicotinamide cocrystal. Pharmaceutical Research 31 (2014) 2312-2325. https://doi.org/10.1007/s11095-014-1326-2 DOI: https://doi.org/10.1007/s11095-014-1326-2
[9] N. Qiao, K. Wang, W. Schlindwein, A. Davies, M. Li. In situ monitoring of carbamazepine-nicotinamide cocrystal intrinsic dissolution behaviour. European Journal of Pharmaceutics and Biopharmaceutics 83 (2013) 415-426. https://doi.org/10.1016/j.ejpb.2012.10.005 DOI: https://doi.org/10.1016/j.ejpb.2012.10.005
[10] H. Yamashita, C.C. Sun. Self-templating accelerates precipitation of carbamazepine dihydrate during the dissolution of a soluble carbamazepine cocrystal. CrystEngComm 19 (2017) 1156-1159. https://doi.org/10.1039/c6ce02418a DOI: https://doi.org/10.1039/C6CE02418A
[11] H. Yamashita, C.C. Sun. Improving Dissolution Rate of Carbamazepine-Glutaric Acid Cocrystal Through Solubilization by Excess Coformer. Pharmaceutical Research 35 (2018). https://doi.org/10.1007/s11095-017-2309-x DOI: https://doi.org/10.1007/s11095-017-2309-x
[12] M. Guo, K. Wang, N. Qiao, L. Fábián, G. Sadiq, M. Li. Insight into flufenamic acid cocrystal dissolution in the presence of a polymer in solution: from single crystal to powder dissolution. Molecular Pharmaceutics 14 (2017) 4583-4596. https://doi.org/10.1021/acs.molpharmaceut.7b00712 DOI: https://doi.org/10.1021/acs.molpharmaceut.7b00712
[13] P. Kirubakaran, K. Wang, I. Rosbottom, R.B.M. Cross, M. Li. Understanding the effects of a polymer on the surface dissolution of pharmaceutical cocrystals using combined experimental and molecular dynamics simulation approaches. Molecular Pharmaceutics (2019). https://doi.org/10.1021/acs.molpharmaceut.9b00955 DOI: https://doi.org/10.1021/acs.molpharmaceut.9b00955
[14] I. Nir, X. Lu. In Situ UV Fiber Optics for Dissolution testing-what, why, and where we are after 30 Years. Dissolut. Technol 25 (2018) 70-77. https://doi.org/10.14227/DT250318P70 DOI: https://doi.org/10.14227/DT250318P70
[15] M. Kataoka, K. Minami, T. Takagi, G.E. Amidon, S. Yamashita. In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior. Molecular Pharmaceutics 18 (2021) 4122-4130. https://doi.org/10.1021/acs.molpharmaceut.1c00537 DOI: https://doi.org/10.1021/acs.molpharmaceut.1c00537
[16] D.J. Leggett. Numerical analysis of multicomponent spectra. Analytical Chemistry 49 (1977) 276-281. https://doi.org/10.1021/ac50010a024 DOI: https://doi.org/10.1021/ac50010a024
[17] P.J. Gemperline, J. Cho, B. Baker, B. Batchelor, D.S. Walker. Determination of multicomponent dissolution profiles of pharmaceutical products by in situ fiber-optic UV measurements. Analytica Chimica Acta 345 (1997) 155-159. https://doi.org/10.1016/S0003-2670(97)00095-0 DOI: https://doi.org/10.1016/S0003-2670(97)00095-0
[18] D. Gupta, S. Bhardwaj, S. Sethi, S. Pramanik, D.K. Das, R. Kumar, P.P. Singh, V.K. Vashistha. Simultaneous spectrophotometric determination of drug components from their dosage formulations. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 270 (2022) 120819. https://doi.org/10.1016/j.saa.2021.120819 DOI: https://doi.org/10.1016/j.saa.2021.120819
[19] L. Zöller, A. Avdeef, E. Karlsson, A. Borde, S. Carlert, C. Saal, J. Dressman. A comparison of USP 2 and μDISS ProfilerTM apparatus for studying dissolution phenomena of ibuprofen and its salts. European Journal of Pharmaceutical Sciences 193 (2024) 106684. https://doi.org/10.1016/j.ejps.2023.106684 DOI: https://doi.org/10.1016/j.ejps.2023.106684
[20] S. Ishida, S. Lee, B. Sinko, K. Box, K. Sugano. Novel stirring method for small-scale dissolution test: Rotating vessel method. ADMET and DMPK (2025) 3136-3136. https://doi.org/10.5599/admet.3136 DOI: https://doi.org/10.5599/admet.3136
[21] A.N. Manin, D.E. Boycov, O.R. Simonova, K.V. Drozd, T.V. Volkova, G.L. Perlovich. How Molecular Packing Affects the Thermodynamic Parameters of Cocrystal Formation: The Case of Carbamazepine Cocrystals. Crystal Growth & Design 24 (2024) 252-261. https://doi.org/10.1021/acs.cgd.3c00949 DOI: https://doi.org/10.1021/acs.cgd.3c00949
[22] R. Salas-Zúñiga, C. Rodríguez-Ruiz, H. Höpfl, H. Morales-Rojas, O. Sánchez-Guadarrama, P. Rodríguez-Cuamatzi, D. Herrera-Ruiz. Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers. Pharmaceutics 12 (2020) 23. https://doi.org/10.3390/pharmaceutics12010023 DOI: https://doi.org/10.3390/pharmaceutics12010023
[23] D.R. Weyna, M.L. Cheney, N. Shan, M. Hanna, M.J. Zaworotko, V. Sava, S. Song, J.R. Sanchez-Ramos. Improving solubility and pharmacokinetics of meloxicam via multiple-component crystal formation. Molecular Pharmaceutics 9 (2012) 2094-2102. https://doi.org/10.1021/mp300169c DOI: https://doi.org/10.1021/mp300169c
[24] M. Yoshimura, M. Miyake, T. Kawato, M. Bando, M. Toda, Y. Kato, T. Fukami, T. Ozeki. Impact of the dissolution profile of the cilostazol cocrystal with supersaturation on the oral bioavailability. Crystal Growth and Design 17 (2017) 550-557. https://doi.org/10.1021/acs.cgd.6b01425 DOI: https://doi.org/10.1021/acs.cgd.6b01425
[25] M. Omori, T. Uekusa, J. Oki, D. Inoue, K. Sugano. Solution-mediated phase transformation at particle surface during cocrystal dissolution. Journal of Drug Delivery Science and Technology 56 (2020) 101566. https://doi.org/10.1016/j.jddst.2020.101566 DOI: https://doi.org/10.1016/j.jddst.2020.101566
Comments (0)