[1] R. Chilton, I. Tikkanen, U. Hehnke, H.J. Woerle, O.E. Johansen. Impact of empagliflozin on blood pressure in dipper and non-dipper patients with type 2 diabetes mellitus and hypertension. Diabetes, Obesity and Metabolism 19 (2017) 1620-1624. https://doi.org/10.1111/dom.12962 DOI: https://doi.org/10.1111/dom.12962

[2] K. Eng, N. Zebardast, V.M. Boland, J.E. Lo, S.S. Swaminathan, D.S. Friedman, K.S.-K. Ma. Sodium-glucose cotransporter 2 inhibitors for the primary prevention of glaucoma in patients with type 2 diabetes: a target trial emulation. American Journal of Ophthalmology 271 (2025) 286-298. https://doi.org/10.1016/j.ajo.2024.10.029 DOI: https://doi.org/10.1016/j.ajo.2024.10.029

[3] K. Kunzmann. SGLT-2 inhibitors reduce glaucoma risk in type 2 diabetes patients. American Academy of Ophthalmology, 2023. https://www.hcplive.com/view/sglt2-inhibitors-glaucoma-risk-type-2-diabetes-patients

[4] S. Ahmed, M.M. El-Sayed, M.A. Kandeil, M.M. Khalaf. Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats. Saudi Pharmaceutical Journal 30 (2022) 863-873. https://doi.org/10.1016/j.jsps.2022.03.005 DOI: https://doi.org/10.1016/j.jsps.2022.03.005

[5] F. Iannantuoni, A.M. de Marañon, N. Diaz-Morales, R. Falcon, C. Bañuls, Z. Abad-Jimenez, V.M. Victor, A. Hernandez-Mijares, S. Rovira-Llopis. The SGLT2 inhibitor empagliflozin ameliorates the inflammatory profile in type 2 diabetic patients and promotes an antioxidant response in leukocytes. Journal of Clinical Medicine 8(1) (2019) 1814. https://doi.org/10.3390/jcm8111814 DOI: https://doi.org/10.3390/jcm8111814

[6] C. Ferrero, D. Massuelle, E. Doelker. Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis. Journal of Controlled Release 141 (2010) 223-233. https://doi.org/10.1016/j.jconrel.2009.09.011 DOI: https://doi.org/10.1016/j.jconrel.2009.09.011

[7] A. Pramanik, R.N. Sahoo, S. Nandi, A. Nanda, S. Mallick. Characterization of hydration behaviour and modeling of film formulation. Acta Chimica Slovenica 68 (2021) 159-169. https://doi.org/10.17344/acsi.2020.6298 DOI: https://doi.org/10.17344/acsi.2020.6298

[8] J.-H. Park, H. Jeong, J. Hong, M. Chang, M. Kim, R.S. Chuck, J.K. Lee, C.-Y. Park. The effect of silica nanoparticles on human corneal epithelial cells. Scientific Reports 6 (2016) 37762. https://doi.org/10.1038/srep37762 DOI: https://doi.org/10.1038/srep37762

[9] E.A. Mun, P.W.J. Morrison, A.C. Williams, V.V. Khutoryanskiy. On the barrier properties of the cornea: a microscopy study of the penetration of fluorescently labeled nanoparticles, polymers, and sodium fluorescein. Molecular Pharmaceutics 11 (2014) 3556-3564. https://doi.org/10.1021/mp500332m DOI: https://doi.org/10.1021/mp500332m

[10] A. Nieto, H. Hou, M.J. Sailor, W.R. Freeman, L. Cheng. Ocular silicon distribution and clearance following intravitreal injection of porous silicon microparticles. Experimental Eye Research 116 (2013) 161-168. https://doi.org/10.1016/j.exer.2013.09.001 DOI: https://doi.org/10.1016/j.exer.2013.09.001

[11] L. Cheng, E. Anglin, F. Cunin, D. Kim, M.J. Sailor, I. Falkenstein, A. Tammewar, W.R. Freeman. Intravitreal properties of porous silicon photonic crystals: a potential self-reporting intraocular drug-delivery vehicle. British Journal of Ophthalmology 92 (2008) 705-711. https://doi.org/10.1136/bjo.2007.133587 DOI: https://doi.org/10.1136/bjo.2007.133587

[12] R. Swain, S. Nandi, R.N. Sahoo, S.S. Swain, S. Mohapatra, S. Mallick. Bentonite clay incorporated topical film formulation for delivery of trimetazidine: control of ocular pressure and in vitro-in vivo correlation. Journal of Drug Delivery Science and Technology 67 (2022) 102956. https://doi.org/10.1016/j.jddst.2021.102956 DOI: https://doi.org/10.1016/j.jddst.2021.102956

[13] R. Swain, A. Moharana, S. Habibullah, S. Nandi, A. Bose, S. Mohapatra, S. Mallick. Ocular delivery of felodipine for the management of intraocular pressure and inflammation: effect of film plasticizer and in vitro-in vivo evaluation. International Journal of Pharmaceutics 642 (2023) 123153. https://doi.org/10.1016/j.ijpharm.2023.123153 DOI: https://doi.org/10.1016/j.ijpharm.2023.123153

[14] M. Das, S. Habibullah, T. Das, R. Swain, S. Mallick. Management of intraocular pressure and inflammation using febuxostat film: in vitro-in vivo correlation. ADMET and DMPK 13 (2025) 2601. https://doi.org/10.5599/admet.2601 DOI: https://doi.org/10.5599/admet.2601

[15] V. Vigoreaux, E.S. Ghaly. Fickian and relaxational contribution quantification of drug release in a swellable hydrophilic polymer matrix. Drug Development and Industrial Pharmacy 20 (1994) 2519-2526. https://doi.org/10.3109/03639049409042655 DOI: https://doi.org/10.3109/03639049409042655

[16] J. Balasubramaniam, A. Srinatha, J. Pandit, G. Nath. In vitro microbiological evaluation of polyvinyl alcohol-based ocular inserts of ciprofloxacin hydrochloride. Indian Journal of Pharmaceutical Sciences 68 (2006) 626-630. https://www.ijpsonline.com/abstract/in-vitro-microbiological-evaluation-of-polyvinyl-alcoholbased-ocular-inserts-of-ciprofloxacin-hydrochloride-397.html DOI: https://doi.org/10.4103/0250-474X.29631

[17] B. Hou, F. Wang, Z. Ye, X. Jin, Y. Fu, Z. Li. Study of minimally invasive radiofrequency ablation of the ciliary body for the treatment of glaucoma in rabbits. Molecular Medicine Reports 21(3) (2020) 1071-1076. https://doi.org/10.3892/mmr.2019.10906 DOI: https://doi.org/10.3892/mmr.2019.10906

[18] Acts, Rules & Guidelines, Committee for Control and Supervision of Experiments on Animals, Ministry of Fisheries, Animal Husbandry and Dairying, Department of Animal Husbandry and Dairying Government of India. https://ccsea.gov.in/Content/54_1_ACTS,RULESANDGUIDELINES.aspx Accessed November 6, 2025.

[19] N. Percie du Sert, V. Hurst, A. Ahluwalia, S. Alam, M.T. Avey, M. Baker, W.J. Browne, A Clark, I.C. Cuthill, U. Dirnagl, M. Emerson, P. Garner, S.T. Holgate, D.W. Howells, N.A. Karp, S. E. Lazic, K. Lidster, C.J. MacCallum, M. Macleod, E.J. Pearl, O.H. Petersen, F. Rawle, P. Reynolds, K. Rooney, E.S. Sena, S.D. Silberberg, T. Steckler, H. Würbel. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. Journal of Cerebral Blood Flow & Metabolism 40(9) (2020) 1769-1777. https://doi.org/10.1177/0271678X20943823 DOI: https://doi.org/10.1177/0271678X20943823

[20] ICH Harmonised Tripartite Guideline: Stability Testing of New Drug Substances and Products Q1A(R2). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, 2003. https://database.ich.org/sites/default/files/Q1A%28R2%29%20Guideline.pdf

[21] A. Topete, B. Saramago, A.P. Serro. Effect of sterilization by steam and pressure and gamma radiation on drug-loaded intraocular lenses for prophylaxis of endophthalmitis. Annals of Medicine 51 (sup1) (2024) 101-102. https://doi.org/10.1080/07853890.2018.1562706 DOI: https://doi.org/10.1080/07853890.2018.1562706

[22] S. Habibullah, J.R. Meher, M. Das, T. Das, R. Swain, B. Mohanty, et al. Moxifloxacin in HPMC-nanocellulose composite film for the management of ocular inflammation: effect of carboxymethylated gum on permeation and antimicrobial activity. International Journal of Biological Macromolecules 310(Part1) (2025) 143302. https://doi.org/10.1016/j.ijbiomac.2025.143302 DOI: https://doi.org/10.1016/j.ijbiomac.2025.143302

[23] S. Bashir, M. Hina, J. Iqbal, A.H. Rajpar, M.A. Mujtaba, N.A. Alghamdi, S. Wageh, K. Ramesh, S. Ramesh. Fundamental concepts of hydrogels: synthesis, properties, and their applications. Polymers (Basel) 12 (2020) 2702. https://doi.org/10.3390/polym12112702 DOI: https://doi.org/10.3390/polym12112702

[24] Mohamed Rizk, A.K. Attia, H.Y. Mohamed, M.S. Elshahed. Thermo analytical study and purity determination of Anti-diabetic drugs Linagliptin and Empagliflozin in drug substances. Chemistry Research Journal 5(4) (2020) 6-20. https://chemrj.org/download/vol-5-iss-4-2020/chemrj-2020-05-04-6-20.pdf

[25] R.P. Bhole, F.R. Tamboli. Development and validation of stability-indicating HPTLC-MS method for estimation of empagliflozin in pharmaceutical dosage form. Analytical Chemistry Letters 8 (2018) 244-256. https://doi.org/10.1080/22297928.2017.1404929 DOI: https://doi.org/10.1080/22297928.2017.1404929

[26] D.M. Widjonarko, J. Jumina, I. Kartini, N. Nuryono. Phosphonate modified silica for adsorption of Co(II), Ni(II), Cu(II), and Zn(II). Indonesian Journal of Chemistry 14 (2014) 143-151. https://doi.org/10.22146/ijc.21251 DOI: https://doi.org/10.22146/ijc.21251

[27] E. Guler, A. Nur Hazar-Yavuz, E. Tatar, M. Morid Haidari, G. Sinemcan Ozcan, G. Duruksu, et al. Oral empagliflozin-loaded tri-layer core-sheath fibers fabricated using tri-axial electrospinning: enhanced in vitro and in vivo antidiabetic performance. International Journal of Pharmaceutics 635 (2023) 122716. https://doi.org/10.1016/j.ijpharm.2023.122716 DOI: https://doi.org/10.1016/j.ijpharm.2023.122716

[28] D.O. Corrigan, A.M. Healy, O.I. Corrigan. The effect of spray drying solutions of polyethylene glycol (PEG) and lactose/PEG on their physicochemical properties. International Journal of Pharmaceutics 235(1-2) (2002) 193-205. https://doi.org/10.1016/S0378-5173(01)00990-5 DOI: https://doi.org/10.1016/S0378-5173(01)00990-5

[29] A.V. Patil, H.S. Mahajan. Modified pea starch-based ocular films of azelastine hydrochloride: development and characterization. Carbohydrate Polymer Technologies and Applications 2 (2021) 100078. https://doi.org/10.1016/j.carpta.2021.100078 DOI: https://doi.org/10.1016/j.carpta.2021.100078

[30] R. Swain, S. Nandi, R.N. Sahoo, S.S. Swain, S. Mohapatra, S. Mallick. Bentonite clay incorporated topical film formulation for delivery of trimetazidine: control of ocular pressure and in vitro-in vivo correlation. Journal of Drug Delivery Science and Technology 67 (2022) 102956. https://doi.org/10.1016/j.jddst.2021.102956 DOI: https://doi.org/10.1016/j.jddst.2021.102956

[31] S. Nandi, R. Swain, S. Habibullah, R.N. Sahoo, A.K. Nayak, S. Mallick. Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intraocular pressure in normotensive rabbit: sustained structural relaxation release kinetics and IVIVC. Pharmaceutical Development and Technology 29 (2024) 468-476. https://doi.org/10.1080/10837450.2024.2345807 DOI: https://doi.org/10.1080/10837450.2024.2345807

[32] H.S. Mahajan, S.R. Deshmukh. Development and evaluation of gel-forming ocular films based on xyloglucan. Carbohydrate Polymers 122 (2015) 243-247. https://doi.org/10.1016/j.carbpol.2015.01.018 DOI: https://doi.org/10.1016/j.carbpol.2015.01.018

[33] European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 3: Treatment principles and options. British Journal of Ophthalmology 101 (2017) 130-195. https://doi.org/10.1136/bjophthalmol-2016-EGSguideline.003 DOI: https://doi.org/10.1136/bjophthalmol-2016-EGSguideline.003

[34] S. Nandi, A. Nanda, R.N. Sahoo, R. Swain, S. Mallick. Formulation and administration of ramipril prodrug for improving bioactivity significantly: in vitro and in vivo correlation. Journal of Drug Delivery Science and Technology 74 (2022) 103597. https://doi.org/10.1016/j.jddst.2022.103597 DOI: https://doi.org/10.1016/j.jddst.2022.103597