Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK (2023) Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 8:553–564
Article CAS PubMed Google Scholar
Chen YC, Malfertheiner P, Yu HT, Kuo CL, Chang YY, Meng FT et al (2024) Global Prevalence of Helicobacter pylori Infection and Incidence of Gastric Cancer Between 1980 and 2022. Gastroenterology 166:605–619
Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C et al (2023) Helicobacter pylori infection. Nat Rev Dis Primers 9:19
Article PubMed PubMed Central Google Scholar
Nath AN, Retnakumar RJ, Francis A, Chhetri P, Thapa N, Chattopadhyay S (2022) Peptic Ulcer and Gastric Cancer: Is It All in the Complex Host-Microbiome Interplay That Is Encoded in the Genomes of Us and Them? Front Microbiol 13:835313
Article PubMed PubMed Central Google Scholar
Liang C, Zhou Y, Li Y, Xu M, Li C (2025) Follow-up and Analysis of Helicobacter pylori Antibiotic Resistance in the South Area of Sichuan Province. J Infect Dis 232:S418–s24
Article CAS PubMed Google Scholar
Tao W, Ma W, Zhao G, Zhang Z, Xu C, Wang P et al (2025) Characterization of antibiotic resistance and biofilm formation in clinical Helicobacter pylori isolates from Ningxia, China. Sci Rep 15:45439
Article CAS PubMed PubMed Central Google Scholar
Zhou D, Wang W, Gu L, Han M, Hao W, Huang J et al (2024) Helicobacter pylori antibiotic resistance profile in Chinese children with upper gastrointestinal symptoms and a literature review for developing personalized eradicating strategies. Front Pharmacol 15:1392787
Article CAS PubMed PubMed Central Google Scholar
Otake K, Sakurai Y, Nishida H, Fukui H, Tagawa Y, Yamasaki H et al (2016) Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438). Adv Ther 33:1140–1157
Article CAS PubMed Google Scholar
Han Z, Zhang Q, Mirza IA, Ding Y, Nan X, Zhao Q et al (2024) Efficacy of Tetracycline Three Times Daily was Comparable to That of Four Times Daily for Helicobacter pylori Rescue Treatment: A Multicenter, Noninferiority, Randomized Controlled Trial. Helicobacter 29:e13102
Article CAS PubMed Google Scholar
Ding YM, Zhang QM, Li RL, Han ZX, Zhao Q, Xu LD et al (2024) Tetracycline Three Times Daily Versus Four Times Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of Helicobacter pylori Infection: A Multicenter, Noninferiority, Randomized Controlled Trial. Helicobacter 29:e13121
Article CAS PubMed Google Scholar
Suzuki S, Gotoda T, Kusano C, Ikehara H, Ichijima R, Ohyauchi M et al (2020) Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: a multicentre randomised trial in Japan. Gut 69:1019–1026
Article CAS PubMed PubMed Central Google Scholar
Sue S, Kondo M, Sato T, Oka H, Sanga K, Ogashiwa T et al (2023) Vonoprazan and high-dose amoxicillin dual therapy for Helicobacter pylori first-line eradication: A single-arm, interventional study. JGH Open 7:55–60
Duggar BM (2011) Aureomycin: a product of the continuing search for new antibiotics. Ann N Y Acad Sci 1241:163–169
Article CAS PubMed Google Scholar
Zhou K, Li CL, Zhang H, Suo BJ, Zhang YX, Ren XL et al (2024) Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis. World J Gastroenterol 30:2354–2368
Article CAS PubMed PubMed Central Google Scholar
Huang Y, Chen J, Ding Z, Chen X, Liang X, Zeng X et al (2023) Minocycline vs. tetracycline in bismuth-containing quadruple therapy for Helicobacter pylori rescue treatment: a multicentre, randomized controlled trial. J Gastroenterol 58:633–641
Article CAS PubMed Google Scholar
Wazir HU, Khuram AM, Reza IMK, Ajmal H, Parveen H, Ahmed Z et al (2026) Efficacy and safety of minocycline-containing bismuth quadruple therapies versus standard first-line bismuth quadruple therapies for Helicobacter pylori eradication: a systematic review and meta-analysis. Infect Dis Rep 18:16
Zhao J, Zou Y, Li K, Huang X, Niu C, Wang Z et al (2021) Doxycycline and minocycline in Helicobacter pylori treatment: A systematic review and meta-analysis. Helicobacter 26:e12839
Kounatidis D, Dalamaga M, Grivakou E, Karampela I, Koufopoulos P, Dalopoulos V et al (2024) Third-generation tetracyclines: Curr Knowl Therapeutic Potential Biomolecules 14:783
Alegun O, Pandeya A, Cui J, Ojo I, Wei Y (2021) Donnan potential across the outer membrane of gram-negative bacteria and its effect on the permeability of antibiotics. Antibiot (Basel) 10:701
Chopra I, Roberts M (2001) Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 65:232–260 second page, table of contents
Article CAS PubMed PubMed Central Google Scholar
Semenova Y, Makalkina L, Glushkova N, Gaipov A (2025) Tetracyclines in the modern era: global consumption, antimicrobial resistance, environmental occurrence, and degradation techniques. Antibiot (Basel) 14:1183
Agwuh KN, MacGowan A (2006) Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother 58:256–265
Article CAS PubMed Google Scholar
Zeng S, Kong Q, Wu X, Duan M, Nan X, Yang X et al (2024) Antibiotic resistance of Helicobacter pylori in Mainland China: A focus on geographic differences through systematic review and meta-analysis. Int J Antimicrob Agents 64:107325
Article CAS PubMed Google Scholar
Menbari S, Shahsavar SK, Keikha M, Karbalaei M (2025) Global Profile of Drug Resistance Related to Helicobacter pylori Infection in Children: A Systematic Review and Meta-Analysis. Health Sci Rep 8:e71238
Article PubMed PubMed Central Google Scholar
Su X, Deng Y, Chen X, Li Y, Hao Q, Tang Y et al (2024) Effect of an individualized bismuth quadruple regimen guided by 10-day or 14-day antibiotic susceptibility testing for first-line eradication treatment of Helicobacter pylori in Ningxia, China. Front Med (Lausanne) 11:1510376
Hu S, Zhou Y, Deng Y, Bo Y, Chen X, Yang W et al (2023) Characteristics of phenotypic antibiotic resistance of Helicobacter pylori and its correlation with genotypic antibiotic resistance: A retrospective study in Ningxia. Helicobacter 28:e12960
Article CAS PubMed Google Scholar
Gerrits MM, de Zoete MR, Arents NL, Kuipers EJ, Kusters JG (2002) 16S rRNA mutation-mediated tetracycline resistance in Helicobacter pylori. Antimicrob Agents Chemother 46:2996–3000
Article CAS PubMed PubMed Central Google Scholar
Sjöström JE, Larsson H (1996) Factors affecting growth and antibiotic susceptibility of Helicobacter pylori: effect of pH and urea on the survival of a wild-type strain and a urease-deficient mutant. J Med Microbiol 44:425–433
Seo JH, Park HK, Park JS, Yeom JS, Lim JY, Park CH et al (2015) Association between Gastric pH and Helicobacter pylori Infection in Children. Pediatr Gastroenterol Hepatol Nutr 18:246–252
Article PubMed PubMed Central Google Scholar
Ibrahim A, Yusuff K, Awaisu A, Elewa H (2025) Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review. Front Pharmacol 16:1523399
Article CAS PubMed PubMed Central Google Scholar
Agago DE, Hanif N, Ajay Kumar AS, Arsalan M, Kaur Dhanjal M, Hanif L et al (2024) Comparison of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cureus 16:e65141
PubMed PubMed Central Google Scholar
Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N et al (2022) Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects. Am J Gastroenterol 117:1158–1161
Article CAS PubMed Google Scholar
Salahi-Niri A, Nabavi-Rad A, Monaghan TM, Rokkas T, Doulberis M, Sadeghi A et al (2024) Global prevalence of Helicobacter pylori antibiotic resistance among children in the world health organization regions between 2000 and 2023: a systematic review and meta-analysis. BMC Med 22:598
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