Tetracycline for eradication: a narrative review from quadruple to dual therapy

Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK (2023) Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 8:553–564

Article  CAS  PubMed  Google Scholar 

Chen YC, Malfertheiner P, Yu HT, Kuo CL, Chang YY, Meng FT et al (2024) Global Prevalence of Helicobacter pylori Infection and Incidence of Gastric Cancer Between 1980 and 2022. Gastroenterology 166:605–619

Article  PubMed  Google Scholar 

Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C et al (2023) Helicobacter pylori infection. Nat Rev Dis Primers 9:19

Article  PubMed  PubMed Central  Google Scholar 

Nath AN, Retnakumar RJ, Francis A, Chhetri P, Thapa N, Chattopadhyay S (2022) Peptic Ulcer and Gastric Cancer: Is It All in the Complex Host-Microbiome Interplay That Is Encoded in the Genomes of Us and Them? Front Microbiol 13:835313

Article  PubMed  PubMed Central  Google Scholar 

Liang C, Zhou Y, Li Y, Xu M, Li C (2025) Follow-up and Analysis of Helicobacter pylori Antibiotic Resistance in the South Area of Sichuan Province. J Infect Dis 232:S418–s24

Article  CAS  PubMed  Google Scholar 

Tao W, Ma W, Zhao G, Zhang Z, Xu C, Wang P et al (2025) Characterization of antibiotic resistance and biofilm formation in clinical Helicobacter pylori isolates from Ningxia, China. Sci Rep 15:45439

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou D, Wang W, Gu L, Han M, Hao W, Huang J et al (2024) Helicobacter pylori antibiotic resistance profile in Chinese children with upper gastrointestinal symptoms and a literature review for developing personalized eradicating strategies. Front Pharmacol 15:1392787

Article  CAS  PubMed  PubMed Central  Google Scholar 

Otake K, Sakurai Y, Nishida H, Fukui H, Tagawa Y, Yamasaki H et al (2016) Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438). Adv Ther 33:1140–1157

Article  CAS  PubMed  Google Scholar 

Han Z, Zhang Q, Mirza IA, Ding Y, Nan X, Zhao Q et al (2024) Efficacy of Tetracycline Three Times Daily was Comparable to That of Four Times Daily for Helicobacter pylori Rescue Treatment: A Multicenter, Noninferiority, Randomized Controlled Trial. Helicobacter 29:e13102

Article  CAS  PubMed  Google Scholar 

Ding YM, Zhang QM, Li RL, Han ZX, Zhao Q, Xu LD et al (2024) Tetracycline Three Times Daily Versus Four Times Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of Helicobacter pylori Infection: A Multicenter, Noninferiority, Randomized Controlled Trial. Helicobacter 29:e13121

Article  CAS  PubMed  Google Scholar 

Suzuki S, Gotoda T, Kusano C, Ikehara H, Ichijima R, Ohyauchi M et al (2020) Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: a multicentre randomised trial in Japan. Gut 69:1019–1026

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sue S, Kondo M, Sato T, Oka H, Sanga K, Ogashiwa T et al (2023) Vonoprazan and high-dose amoxicillin dual therapy for Helicobacter pylori first-line eradication: A single-arm, interventional study. JGH Open 7:55–60

Article  PubMed  Google Scholar 

Duggar BM (2011) Aureomycin: a product of the continuing search for new antibiotics. Ann N Y Acad Sci 1241:163–169

Article  CAS  PubMed  Google Scholar 

Zhou K, Li CL, Zhang H, Suo BJ, Zhang YX, Ren XL et al (2024) Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis. World J Gastroenterol 30:2354–2368

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Chen J, Ding Z, Chen X, Liang X, Zeng X et al (2023) Minocycline vs. tetracycline in bismuth-containing quadruple therapy for Helicobacter pylori rescue treatment: a multicentre, randomized controlled trial. J Gastroenterol 58:633–641

Article  CAS  PubMed  Google Scholar 

Wazir HU, Khuram AM, Reza IMK, Ajmal H, Parveen H, Ahmed Z et al (2026) Efficacy and safety of minocycline-containing bismuth quadruple therapies versus standard first-line bismuth quadruple therapies for Helicobacter pylori eradication: a systematic review and meta-analysis. Infect Dis Rep 18:16

Zhao J, Zou Y, Li K, Huang X, Niu C, Wang Z et al (2021) Doxycycline and minocycline in Helicobacter pylori treatment: A systematic review and meta-analysis. Helicobacter 26:e12839

Article  PubMed  Google Scholar 

Kounatidis D, Dalamaga M, Grivakou E, Karampela I, Koufopoulos P, Dalopoulos V et al (2024) Third-generation tetracyclines: Curr Knowl Therapeutic Potential Biomolecules 14:783

Alegun O, Pandeya A, Cui J, Ojo I, Wei Y (2021) Donnan potential across the outer membrane of gram-negative bacteria and its effect on the permeability of antibiotics. Antibiot (Basel) 10:701

Chopra I, Roberts M (2001) Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 65:232–260 second page, table of contents

Article  CAS  PubMed  PubMed Central  Google Scholar 

Semenova Y, Makalkina L, Glushkova N, Gaipov A (2025) Tetracyclines in the modern era: global consumption, antimicrobial resistance, environmental occurrence, and degradation techniques. Antibiot (Basel) 14:1183

Agwuh KN, MacGowan A (2006) Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother 58:256–265

Article  CAS  PubMed  Google Scholar 

Zeng S, Kong Q, Wu X, Duan M, Nan X, Yang X et al (2024) Antibiotic resistance of Helicobacter pylori in Mainland China: A focus on geographic differences through systematic review and meta-analysis. Int J Antimicrob Agents 64:107325

Article  CAS  PubMed  Google Scholar 

Menbari S, Shahsavar SK, Keikha M, Karbalaei M (2025) Global Profile of Drug Resistance Related to Helicobacter pylori Infection in Children: A Systematic Review and Meta-Analysis. Health Sci Rep 8:e71238

Article  PubMed  PubMed Central  Google Scholar 

Su X, Deng Y, Chen X, Li Y, Hao Q, Tang Y et al (2024) Effect of an individualized bismuth quadruple regimen guided by 10-day or 14-day antibiotic susceptibility testing for first-line eradication treatment of Helicobacter pylori in Ningxia, China. Front Med (Lausanne) 11:1510376

Article  PubMed  Google Scholar 

Hu S, Zhou Y, Deng Y, Bo Y, Chen X, Yang W et al (2023) Characteristics of phenotypic antibiotic resistance of Helicobacter pylori and its correlation with genotypic antibiotic resistance: A retrospective study in Ningxia. Helicobacter 28:e12960

Article  CAS  PubMed  Google Scholar 

Gerrits MM, de Zoete MR, Arents NL, Kuipers EJ, Kusters JG (2002) 16S rRNA mutation-mediated tetracycline resistance in Helicobacter pylori. Antimicrob Agents Chemother 46:2996–3000

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sjöström JE, Larsson H (1996) Factors affecting growth and antibiotic susceptibility of Helicobacter pylori: effect of pH and urea on the survival of a wild-type strain and a urease-deficient mutant. J Med Microbiol 44:425–433

Article  PubMed  Google Scholar 

Seo JH, Park HK, Park JS, Yeom JS, Lim JY, Park CH et al (2015) Association between Gastric pH and Helicobacter pylori Infection in Children. Pediatr Gastroenterol Hepatol Nutr 18:246–252

Article  PubMed  PubMed Central  Google Scholar 

Ibrahim A, Yusuff K, Awaisu A, Elewa H (2025) Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review. Front Pharmacol 16:1523399

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agago DE, Hanif N, Ajay Kumar AS, Arsalan M, Kaur Dhanjal M, Hanif L et al (2024) Comparison of Potassium-Competitive Acid Blockers and Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cureus 16:e65141

PubMed  PubMed Central  Google Scholar 

Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N et al (2022) Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects. Am J Gastroenterol 117:1158–1161

Article  CAS  PubMed  Google Scholar 

Salahi-Niri A, Nabavi-Rad A, Monaghan TM, Rokkas T, Doulberis M, Sadeghi A et al (2024) Global prevalence of Helicobacter pylori antibiotic resistance among children in the world health organization regions between 2000 and 2023: a systematic review and meta-analysis. BMC Med 22:598

Article  PubMed 

Comments (0)

No login
gif