Therapeutic targeting of COX-2 in head and neck cancer: Mechanistic and clinical perspectives

Sim F, Leidner R, Bell RB. Immunotherapy for Head and Neck Cancer. Hematol Oncol Clin North Am. 2019;33:301–21.

Article  PubMed  Google Scholar 

Weaver A, Smith M, Wilson S, Douglas CM, Montgomery J, Finlay F. Palliation of head and neck cancer: a review of the unique difficulties. Int J Palliat Nurs. 2022;28:333–41.

Article  PubMed  Google Scholar 

Kristensen MB, Isenring E, Brown B. Nutrition and swallowing therapy strategies for patients with head and neck cancer. Nutrition. 2020;69:110548.

Article  PubMed  Google Scholar 

Ng WT, Wong ECY, Lee VHF, Chan JYW, Lee AWM. Head and neck cancer in Hong Kong. Jpn J Clin Oncol. 2018;48:13–21.

Article  PubMed  Google Scholar 

Huang SH, O’Sullivan B. Overview of the 8th Edition TNM Classification for Head and Neck Cancer. Curr Treat Options Oncol. 2017;18:40.

Article  PubMed  Google Scholar 

Hulse K, Li LQ, Lowit A, Maguire R, Douglas C. Digital health in head and neck cancer: a systematic review. J Laryngol Otol. 2023;137:1312–25.

Article  PubMed  Google Scholar 

Alterio D, Marvaso G, Ferrari A, Volpe S, Orecchia R, Jereczek-Fossa BA. Modern radiotherapy for head and neck cancer. Semin Oncol. 2019;46:233–45.

Article  CAS  PubMed  Google Scholar 

Gormley M, Creaney G, Schache A, Ingarfield K, Conway DI. Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. Br Dent J. 2022;233:780–6.

Article  PubMed  PubMed Central  Google Scholar 

Mascagni I, Bossi P. The loop between inflammation and late systemic toxicity in head and neck cancer survivors. Crit Rev Oncol Hematol. 2025;213:104781.

Article  PubMed  Google Scholar 

Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, et al. Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review. Adv Ther. 2022;39:1502–23.

Article  PubMed  PubMed Central  Google Scholar 

Marcus C, Subramaniam RM. Role of Non-FDG-PET/CT in Head and Neck Cancer. Semin Nucl Med. 2021;51:68–78.

Article  PubMed  Google Scholar 

Thi Thanh Nguyen N, Yoon Lee S. Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction. Biochem Pharmacol. 2024;224:116221.

Article  CAS  PubMed  Google Scholar 

Wilken R, Veena MS, Wang MB, Srivatsan ES, Curcumin. A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 2011;10:12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson JC, Anderson LA, Murray LJ, Hughes CM. Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer: a systematic review. Cancer Causes Control. 2011;22:803–10.

PubMed  Google Scholar 

Möbius C, Stein HJ, Spiess C, Becker I, Feith M, Theisen J, et al. COX2 expression, angiogenesis, proliferation and survival in Barrett’s cancer. Eur J Surg Oncol. 2005;31:755–9.

Article  PubMed  Google Scholar 

Peltanova B, Liskova M, Gumulec J, Raudenska M, Polanska HH, Vaculovic T, et al. Sensitivity to Cisplatin in Head and Neck Cancer Cells Is Significantly Affected by Patient-Derived Cancer-Associated Fibroblasts. Int J Mol Sci. 2021;22:31–40.

Article  Google Scholar 

Lin DT, Subbaramaiah K, Shah JP, Dannenberg AJ, Boyle JO. Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. Head Neck. 2002;24:792–9.

Article  PubMed  Google Scholar 

Mendes RA, Carvalho JF, Waal I. An overview on the expression of cyclooxygenase-2 in tumors of the head and neck. Oral Oncol. 2009;45:e124–8.

Article  CAS  PubMed  Google Scholar 

Lang S, Zeidler R. Immune restoration in head and neck cancer patients via cyclooxygenase inhibition: an update. Int J Immunopathol Pharmacol. 2003;16:41–8.

CAS  PubMed  Google Scholar 

Saito S, Ozawa H, Imanishi Y, Sekimizu M, Watanabe Y, Ito F, et al. Cyclooxygenase-2 expression is associated with chemoresistance through cancer stemness property in hypopharyngeal carcinoma. Oncol Lett. 2021;22:533.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han S, Bommireddy R, Kim P, Selvaraj P, Shin DM. Chemoprevention of Head and Neck Cancer: A Review of Current Approaches and Future Perspectives. Cancer Prev Res (Phila). 2024;17:443–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim YY, Lee EJ, Kim YK, Kim SM, Park JY, Myoung H, et al. Anti-cancer effects of celecoxib in head and neck carcinoma. Mol Cells. 2010;29:185–94.

Article  CAS  PubMed  Google Scholar 

Xing A, Lv D, Wu C, Zhou K, Zhao T, Zhao L, et al. Tertiary Lymphoid Structures Gene Signature Predicts Prognosis and Immune Infiltration Analysis in Head and Neck Squamous Cell Carcinoma. Curr Genomics. 2024;25:88–104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang YW, Huang BR, Lu DY, Chen JW, Charoensaensuk V, Yang LY, et al. Fenofibrate Inhibits LPS and Zymosan-induced Inflammatory Responses through Sonic Hedgehog in IMG Cells. Curr Mol Pharmacol. 2024;17:e18761429317532.

Article  CAS  PubMed  Google Scholar 

Sundararajan K, Gurusamy V, Venkatesh S, Saraswathi M. COX-2 Expression as a Prognostic Inflammatory Marker in Head and Neck Squamous Cell Carcinoma: A Cross-sectional Study. 2023;12;09–013.

Biasin FF, Franco AM, Louzeiro GC, Cherubini K, Salum FG. Association of COX-2, TNF-α, TLR4, and IKKα With Survival of Patients With Oral Squamous Cell Carcinomas: A Systematic Review. Asian Pac J Cancer Prevention: APJCP. 2024;25:757.

Article  CAS  Google Scholar 

Alqudah A, Barakat M, Alzaghari LF, Qnais E, Gammoh O, Alqudah M, et al. Mechanistic Insights into Isorhamnetin: Targeting MAPK and NF-κB Pathways to Mitigate LPS-Induced Inflammation. Curr Mol Pharmacol. 2024;17:e18761429385248.

CAS  PubMed  Google Scholar 

Kashfi K, Rigas B. Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention. Biochem Pharmacol. 2005;70:969–86.

Article  CAS  PubMed  Google Scholar 

Peng Y, Wang Y, Tang N, Sun D, Lan Y, Yu Z, et al. Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway. J Exp Clin Cancer Res. 2018;37:248.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Howe LR, Dannenberg AJ. COX-2 inhibitors for the prevention of breast cancer. J Mammary Gland Biol Neoplasia. 2003;8:31–43.

Article  PubMed  Google Scholar 

Hashemi Goradel N, Najafi M, Salehi E, Farhood B, Mortezaee K. Cyclooxygenase-2 in cancer: A review. J Cell Physiol. 2019;234:5683–99.

Article  CAS  PubMed  Google Scholar 

Fournier DB, Gordon GB. COX-2 and colon cancer: potential targets for chemoprevention. J Cell Biochem Suppl. 2000;34:97–102.

Article  CAS  PubMed  Google Scholar 

Giercksky KE. COX-2 inhibition and prevention of cancer. Best Pract Res Clin Gastroenterol. 2001;15:821–33.

Article  CAS  PubMed  Google Scholar 

Harper KA, Tyson-Capper AJ. Complexity of COX-2 gene regulation. Biochem Soc Trans. 2008;36:543–5.

Article  CAS 

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