Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance

Maurya R, Vikal A, Patel P, Narang RK, Kurmi BD. “Enhancing oral drug absorption: overcoming physiological and pharmaceutical barriers for improved bioavailability.” AAPS PharmSciTech. 2024;25:228. https://doi.org/10.1208/s12249-024-02940-5.

Article  PubMed  Google Scholar 

Bhalani DV, Nutan B, Kumar A, Singh Chandel AK. Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines. 2022;10:2055. https://doi.org/10.3390/biomedicines10092055.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lou J, Duan H, Qin Q, Teng Z, Gan F, Zhou X. Advances in oral drug delivery systems: challenges and opportunities. Pharmaceutics. 2023;15(2):484. https://doi.org/10.3390/pharmaceutics15020484.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumari L, Choudhari Y, Patel P, Gupta GD, Singh D, Rosenholm JM, et al. Advancement in solubilization approaches: a step towards bioavailability enhancement of poorly soluble drugs. Life. 2023;13(5):1099. https://doi.org/10.3390/life13051099.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salawi A. Pharmaceutical coating and its different approaches, a review. Polymers. 2022;14(16):3318. https://doi.org/10.3390/polym14163318.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hwang SR, Chakraborty K, An JM, Mondal J, Yoon HY, Lee Y. Pharmaceutical aspects of nanocarriers for smart anticancer therapy. Pharmaceutics. 2021;13:1875. https://doi.org/10.3390/pharmaceutics13111875.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sato H, Yamada K, Miyake M, Onoue S. Recent advancements in the development of nanocarriers for mucosal drug delivery systems to control oral absorption. Pharmaceutics. 2023;15:2708. https://doi.org/10.3390/pharmaceutics15122708.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agwa MM, Marzouk RE, Sabra SA. Advances in active targeting of ligand-directed polymeric nanomicelles via exploiting overexpressed cellular receptors for precise nanomedicine. RSC Adv. 2024;14:23520–42. https://doi.org/10.1039/D4RA04069D.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tollemeto M, Huang Z, Christensen JB, Mørck Nielsen H, Rønholt S. Mucoadhesive dendrons conjugated to mesoporous silica nanoparticles as a drug delivery approach for orally administered biopharmaceuticals. ACS Appl Mater Interfaces. 2023;15:8798–810. https://doi.org/10.1021/acsami.2c16502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jadhav V, Roy A, Kaur K, Rai AK, Rustagi S. Recent advances in nanomaterial-based drug delivery systems. Nano-Struct Nano-Obj. 2024;37:101103. https://doi.org/10.1016/j.nanoso.2024.101103.

Article  CAS  Google Scholar 

Ortiz AC, Carrasco-Rojas J, Peñaloza S, Simirgiotis MJ, Rubio-Quiroz L, Ruiz D, et al. Influence of an antioxidant nanomaterial on oral tablet formulation: flow properties and critical quality attributes. Antioxidants Basel. 2025;14(7):829. https://doi.org/10.3390/antiox14070829.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alshora D, Alyousef W, Ibrahim M. Effects of functional biomaterials on the attributes of orally disintegrating tablets loaded with furosemide nanoparticles: in vitro and in vivo evaluations. J Funct Biomater. 2024;15:161. https://doi.org/10.3390/jfb15060161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vllasaliu D. Grand challenges in oral drug delivery. Front Drug Deliv. 2025. https://doi.org/10.3389/fddev.2025.1571982.

Article  PubMed  PubMed Central  Google Scholar 

Alqahtani MS, Kazi M, Alsenaidy MA, Ahmad MZ. Advances in oral drug delivery. Front Pharmacol. 2021. https://doi.org/10.3389/fphar.2021.618411.

Article  PubMed  PubMed Central  Google Scholar 

Frijlink H, Lagarce F, Touw D, Woerdenbag H. Biopharmaceutics. In: Le Brun P, Crauste-Manciet S, Krämer I, Smith J, Woerdenbag H, editors. Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products. Cham: Springer International Publishing; 2023. p. 67–91. https://doi.org/10.1007/978-3-031-20298-8_5.

Chapter  Google Scholar 

Sohail Arshad M, Zafar S, Yousef B, Alyassin Y, Ali R, AlAsiri A, et al. A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing. Adv Drug Deliv Rev. 2021;178:113840. https://doi.org/10.1016/j.addr.2021.113840.

Article  CAS  PubMed  Google Scholar 

Janssen PHM, Fathollahi S, Bekaert B, Vanderroost D, Roelofs T, Vanhoorne V, et al. Impact of material properties and process parameters on tablet quality in a continuous direct compression line. Powder Technol. 2023;424:118520. https://doi.org/10.1016/j.powtec.2023.118520.

Article  CAS  Google Scholar 

Janssen PHM, Fathollahi S, Dickhoff BHJ, Frijlink HW. Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing. Expert Opin Drug Deliv. 2024;21(7):1069–79. https://doi.org/10.1080/17425247.2024.2384698.

Article  CAS  PubMed  Google Scholar 

Parikh DM, editor. Handbook of Pharmaceutical Granulation Technology. 4th ed. Boca Raton: CRC; 2021. https://doi.org/10.1201/9780429320057.

Book  Google Scholar 

Rowe JM, Charlton ST, McCann RJ. Chapter 32 - Development, Scale-Up, and Optimization of Process Parameters: Roller Compaction Theory and Practice. In: Qiu Y, Chen Y, Zhang GGZ, Yu L, Mantri RV, editors. Developing Solid Oral Dosage Forms (Second Edition) [Internet]. Boston: Academic Press; 2017. pp. 869–915. https://doi.org/10.1016/B978-0-12-802447-8.00032-7

Vadaga AK, Gudla SS, Nareboina GSK, Gubbala H, Golla B. Comprehensive review on modern techniques of granulation in pharmaceutical solid dosage forms. Intell Pharm. 2024;2(5):609–29. https://doi.org/10.1016/j.ipha.2024.05.006.

Article  CAS  Google Scholar 

Bin LK, Gaurav A, Mandal UK. A review on co-processed excipients: current and future trend of excipient technology. Int J Pharm Pharm Sci. 2019(1). https://doi.org/10.22159/ijpps.2019v11i1.29265.

Makkad S, Sheikh M, Shende S, Jirvankar P. Pharmaceutical excipients: functions, selection criteria, and emerging trends. Int J Pharm Investig. 2025;15(2):361–76. https://doi.org/10.5530/ijpi.20251676.

Article  CAS  Google Scholar 

Suzuki Y, Sugiyama H, Kano M, Shimono R, Shimada G, Furukawa R, et al. Control strategy and methods for continuous direct compression processes. Asian J Pharm Sci. 2021;16(2):253–62. https://doi.org/10.1016/j.ajps.2020.11.005.

Article  PubMed  Google Scholar 

Auel T, Mentrup AFC, Oldfield LR, Seidlitz A. 3D printing of pharmaceutical dosage forms: recent advances and applications. Adv Drug Deliv Rev. 2025;217:115504. https://doi.org/10.1016/j.addr.2024.115504.

Article  CAS  PubMed  Google Scholar 

Siamidi A, Tsintavi E, Rekkas DM, Vlachou M, Siamidi A, Tsintavi E et al. 3D-Printed Modified-Release Tablets: A Review of the Recent Advances. Molecular Pharmacology. IntechOpen; 2020. https://doi.org/10.5772/intechopen.90868

Saleh-Bey-Kinj Z, Heller Y, Socratous G, Christodoulou P. 3D printing in oral drug delivery: technologies, clinical applications and future perspectives in precision medicine. Pharmaceuticals. 2025;18(7):973. https://doi.org/10.3390/ph18070973.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Chen X, Han X, Hong X, Li X, Zhang H, et al. A review of 3D printing technology in pharmaceutics: technology and applications, now and future. Pharmaceutics. 2023;15(2):416. https://doi.org/10.3390/pharmaceutics15020416.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nayak VAS, Sathyanarayana UY, Chaudhari MB, Bhat BB. K. Formulation Strategy of BCS-II Drugs by Coupling Mechanistic In-Vitro and Nonclinical In-Vivo Data with PBPK: Fundamentals of Absorption-Dissolution to Parameterization of Modelling and Simulation. AAPS PharmSciTech. 2025;26:106. https://doi.org/10.1208/s12249-025-03093-9

Dahlgren D, Lennernäs H. Intestinal permeability and drug absorption: predictive experimental, computational and in vivo approaches. Pharmaceutics. 2019;11:411. https://doi.org/10.3390/pharmaceutics11080411.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jambhekar SS, Breen PJ. Drug dissolution: significance of physicochemical properties and physiological conditions. Drug Discov Today. 2013;18:1173–84.

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