Pharmaceutically engineered olfactory-masking agents: Innovating oral drug delivery through multisensory excipient design

Malkawi WA, AlRafayah E, AlHazabreh M, AbuLaila S, Al-Ghananeem AM. Formulation challenges and strategies to develop pediatric dosage forms. Children. 2022;9(4). https://doi.org/10.3390/children9040488.

Filibeck U, Sanzi E. GCP and Quality in Regulation (EU) 536/2014 on clinical trials on medicinal products for human use and repealing Directive 2001/20/EU. Microchem J. 2018;136:40–2. https://doi.org/10.1016/j.microc.2017.08.003.

Article  CAS  Google Scholar 

Orubu ESF, Duncan J, Tuleu C, Turner MA, Nunn A. WHO essential medicines for children 2011–2019: Age-appropriateness of enteral formulations. Arch Dis Child. 2021;107(4):317–22. https://doi.org/10.1136/archdischild-2021-321831.

Article  PubMed  Google Scholar 

Uchida T. Taste sensor assessment of bitterness in medicines: Overview and recent topics. Sensors. 2024;24(15):4799. https://doi.org/10.3390/s24154799.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adamkiewicz L, Szeleszczuk Ł. Review of applications of cyclodextrins as taste-masking excipients for pharmaceutical purposes. Molecules. 2023;28(19):6964. https://doi.org/10.3390/molecules28196964.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu S, Liu X, Zhang S, Quan D. An overview of taste-masking technologies: Approaches, application, and assessment methods. AAPS PharmSciTech. 2023;24(2). https://doi.org/10.1208/s12249-023-02520-z.

Taruno A, Nomura K, Kusakizako T, Ma Z, Nureki O, Foskett JK. Taste transduction and channel synapses in taste buds. Pflügers Archiv - Eur J Physiol. 2020;473(1):3–13. https://doi.org/10.1007/s00424-020-02464-4.

Article  CAS  Google Scholar 

Ahmad R, Dalziel JE. G protein-coupled receptors in taste physiology and pharmacology. Front Pharmacol. 2020;11. https://doi.org/10.3389/fphar.2020.587664.

Banerjee S, Joshi U, Singh A, Saharan VA. Lipids for Taste masking and Taste assessment in pharmaceutical formulations. Chem Phys Lipids. 2021;235:105031. https://doi.org/10.1016/j.chemphyslip.2020.105031.

Article  CAS  PubMed  Google Scholar 

Spaggiari G, Di Pizio A, Cozzini P. Sweet, umami and bitter taste receptors: State of the art of in silico molecular modeling approaches. Trends Food Sci Technol. 2020;96:21–9. https://doi.org/10.1016/j.tifs.2019.12.002.

Article  CAS  Google Scholar 

Pockle RD, Masareddy RS, Patil AS, Patil PD. A comprehensive review on pharmaceutical excipients. Therapeutic Delivery. 2023;14(7):443–58. https://doi.org/10.4155/tde-2023-0026.

Article  CAS  PubMed  Google Scholar 

Santoveña-Estévez A, Suárez-González J, Vera M, González-Martín C, Soriano M, Fariña JB. Effectiveness of antimicrobial preservation of extemporaneous diluted simple syrup vehicles for pediatrics. J Pediatr Pharmacol Ther. 2018;23(5):405–9. https://doi.org/10.5863/1551-6776-23.5.405.

Article  PubMed  PubMed Central  Google Scholar 

Kaushik P, Mittal V, Kaushik D. Unleashing the Potential of β –cyclodextrin Inclusion Complexes in Bitter Taste Abatement: Development, Optimization and Evaluation of Taste Masked Anti-emetic Chewing Gum of Promethazine Hydrochloride. AAPS PharmSciTech. 2024;25(6). https://doi.org/10.1208/s12249-024-02888-6.

Morin-Crini N, Fourmentin S, Fenyvesi É, Lichtfouse E, Torri G, Fourmentin M, Crini G. (2020). History of cyclodextrins. In Environmental Chemistry for a Sustainable World (pp. 1–93). Springer International Publishing. https://doi.org/10.1007/978-3-030-49308-0_1

Lewandowska I, Zielińska-Pisklak M, Szeleszczu Ł, Pisklak DM, Sobczak M. CYKLODEKSTRYNY — ZASTOSOWANIE W PRZEMYŚLE FARMACEUTYCZNYM. Prospects Pharm Sci. 2020;18(3):19–26. https://doi.org/10.56782/pps.16.

Article  Google Scholar 

Mazurek AH, Szeleszczuk Ł. A review of applications of solid-state nuclear magnetic resonance (ssnmr) for the analysis of cyclodextrin-including systems. Int J Mol Sci. 2023;24(4):3648. https://doi.org/10.3390/ijms24043648.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Napiórkowska E. Overview of cyclodextrins and medicinal products containing cyclodextrins currently registered in Poland. Prospects Pharm Sci. 2023;21(3):30–7. https://doi.org/10.56782/pps.161.

Article  CAS  Google Scholar 

Marzouk MA, Osman DA, Mohamed OS. In vitro and in vivo evaluation of taste-masked orodispersible tablets of fluoxetine hydrochloride for the treatment of depression. Drug Dev Ind Pharm. 2021;47(4):645–53. https://doi.org/10.1080/03639045.2021.1908336.

Article  CAS  PubMed  Google Scholar 

Li S, Zhang Y, Khan AR, He S, Wang Y, Xu J, Zhai G. Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin: A biosensor evaluation and interaction study. Asian J Pharm Sci. 2020;15(4):492–505. https://doi.org/10.1016/j.ajps.2019.11.001.

Article  PubMed  Google Scholar 

Musuc AM, Anuta V, Atkinson I, Popa VT, Sarbu I, Mircioiu C, Abdalrb GA, Mitu MA, Ozon EA. Development and characterization of orally disintegrating tablets containing a captopril-cyclodextrin complex. Pharmaceutics. 2020;12(8):744. https://doi.org/10.3390/pharmaceutics12080744.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cirri M, Maestrelli F, Mennini N, Di Cesare Mannelli L, Micheli L, Ghelardini C, Mura P. Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of cyclodextrins and hydrophilic polymers. Int J Pharm. 2020;587:119692. https://doi.org/10.1016/j.ijpharm.2020.119692.

Article  CAS  PubMed  Google Scholar 

Li C, Yuan J, Zhang H, Liu N, Wang Z, Zheng A, Bo X. Taste-masking mechanism of brivaracetam oral solution using cyclodextrin and sodium carboxymethyl cellulose. Int J Pharm. 2025b;675:125368. https://doi.org/10.1016/j.ijpharm.2025.125368.

Article  CAS  PubMed  Google Scholar 

Sanjay LR, Ashokbhai MK, Ghatole S, Roy S, Kashinath KP, Kaity S. (n.d.). Strategies for beating the bitter taste of pharmaceutical formulations towards better therapeutic outcomes. RSC Pharm, 2(1), 59–81. https://doi.org/10.1039/D4PM00191E

Kumar M, Kaushik D. An overview on various approaches and recent patents on gastroretentive drug delivery systems. Recent Pat Drug Deliv Formul. 2018;12(2):84–92. https://doi.org/10.2174/1872211312666180308150218.

Article  CAS  PubMed  Google Scholar 

Rani KC, Jayani NiE, Feneke F, Melanda S. (2021). Preparation and evaluation of gelatin and pectin-based Moringa oleifera chewable-gummy tablets. IOP Conference Series: Earth and Environmental Science, 913(1), 012082. https://doi.org/10.1088/1755-1315/913/1/012082

Priya Dharshini K, Fang H, Devi R, Yang D, Luo J-X, Zheng R-H, Brzeziński Y-T, M., Vedha Hari BN. pH-sensitive chitosan nanoparticles loaded with dolutegravir as milk and food admixture for paediatric anti-HIV therapy. Carbohydr Polym. 2021;256:117440. https://doi.org/10.1016/j.carbpol.2020.117440.

Article  CAS  PubMed  Google Scholar 

Seeli DS, Prabaharan M. (2019). Guar gum and its derivatives: Pharmaceutical applications. In Natural Polymers for Pharmaceutical Applications (pp. 115–138). Apple Academic Press. https://doi.org/10.1201/9780429328251-5

Lomartire S, Gonçalves AMM. An overview of potential seaweed-derived bioactive compounds for pharmaceutical applications. Mar Drugs. 2022;20(2):141. https://doi.org/10.3390/md20020141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zhang D, Ash J, Jia X, Leone A, Templeton A. Mechanism and impact of excipient incompatibility: Cross-Linking of xanthan gum in pediatric powder-for-suspension formulations. J Pharm Sci. 2019;108(11):3609–15. https://doi.org/10.1016/j.xphs.2019.07.005.

Article  CAS  PubMed  Google Scholar 

Rajeswari S, Kudamala S, Murthy KVR, AND EVALUATION OF A BILAYER GASTRIC RETENTIVE FLOATING TABLETS OF RANITIDINE HCL AND CLARITHROMYCIN USING NATURAL POLYMERS. DEVELOPMENT, FORMULATION. Int J Pharm Pharm Sci. 2017;9(9):164. https://doi.org/10.22159/ijpps.2017v9i9.20290.

Article  CAS  Google Scholar 

Halake K, Birajdar M, Kim BS, Bae H, Lee C, Kim YJ, Kim S, Kim HJ, Ahn S, An SY, Lee J. Recent application developments of water-soluble synthetic polymers. J Ind Eng Chem. 2014;20(6):3913–8. https://doi.org/10.1016/j.jiec.2014.01.006.

Article  CAS  Google Scholar 

Thoorens G, Krier F, Leclercq B, Carlin B, Evrard B. Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review. Int J Pharm. 2014;473(1–2):64–72. https://doi.org/10.1016/j.ijpharm.2014.06.055.

Article  CAS  PubMed  Google Scholar 

Shirodkar RK, Kumar L, Mutalik S, Lewis S. Solid lipid nanoparticles and nanostructured lipid carriers: Emerging lipid based drug delivery systems. Pharm Chem J. 2019b;53(5):440–53. https://doi.org/10.1007/s11094-019-02017-9.

Article  CAS  Google Scholar 

Samimi S, Maghsoudnia N, Eftekhari RB, Dorkoosh F. (2019b). Lipid-Based nanoparticles for drug delivery systems. In Characterization and Biology of Nanomaterials for Drug Delivery (pp. 47–76). Elsevier. https://doi.org/10.1016/b978-0-12-814031-4.00003-9

Nguyen VH, Thuy VN, Van TV, Dao AH, Lee B-J. Nanostructured lipid carriers and their potential applications for versatile drug delivery via oral administration. OpenNano. 2022b;8:100064. https://doi.org/10.1016/j.onano.2022.100064.

Article  CAS 

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